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Benzophenone compound with antioxidant activity and preparation method and application thereof

A technology for benzophenones and compounds is applied in the field of benzophenones and their preparation, and can solve problems such as large toxic and side effects, instability and the like

Active Publication Date: 2018-01-16
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antioxidants currently on the market have the characteristics of large toxic side effects or instability

Method used

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  • Benzophenone compound with antioxidant activity and preparation method and application thereof
  • Benzophenone compound with antioxidant activity and preparation method and application thereof
  • Benzophenone compound with antioxidant activity and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Talaromyces islandicus, a fungus of the genus Talaromyces islandicus, was preserved in the China General Microorganism Culture Collection Management Center, with a preservation date of March 17, 2016 and a preservation number of (CGMCC 12224). The strain was green mycelium in the initial stage on the PDA plate, and orange-red spores grew on the surface of the mycelium in the later stage.

Embodiment 2

[0031] Fermentative production and separation and purification of compounds 1 and 2:

[0032] 1) Fermentation production

[0033] Fermentation culture of production bacteria:

[0034] Strain culture: Talaromyces islandicus strains are agar-malt extract medium (agar-malt extract medium is malt extract 15g / L, agar 20g / L, pure seawater 1000mL, pH 7.4-7.8) , stored at 4°C. Get Talaromyces islandicus and inoculate it on a PDA plate, and cultivate it in an incubator at 28°C for 4 days;

[0035] Then take a size of 4cm from the above-mentioned flat plate 2 Put the mycelium of the sterilized rice solid medium (solid medium is rice 70g / bottle, peptone 0.3g / bottle, corn steep liquor 0.1g / bottle, water 100mL, pH 6.5) into a cone with a capacity of 1000mL Shaped bottle, stand at room temperature and cultivate for 30 days, ready to use.

[0036] 2) Obtaining the extract

[0037] The solid fermentation product obtained by fermenting and cultivating the above-mentioned rice solid mediu...

Embodiment 3

[0051] Embodiment 3: with half maximal inhibitory concentration (IC 50 ) method to detect the scavenging activity of compound 1 shown in formula I and compound 2 shown in formula II to DPPH and ABTS two kinds of free radicals

[0052] (I) Scavenging activity on DPPH free radicals:

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Abstract

The invention relates to the technical field of microbial metabolites and particularly relates to a benzophenone compound with antioxidant activity and a preparation method and application thereof. Talaromyces islandicus is preserved in the China general microbiological culture collection center on March 17, 2016 and has the preservation number of CGMCC 12224. The Talaromyces islandicus is fermented to form a compound shown in the formula I or II. The Talaromyces islandicus is preserved in the China general microbiological culture collection center on March 17, 2016 and has the preservation number of CGMCC 12224. Experiment results show that the compound has good antioxidant activity and can be used for preparation of drugs, foods or cosmetic additives related to anti-oxidation effects.

Description

technical field [0001] The invention relates to the technical field of microbial metabolites, in particular to a benzophenone compound with antioxidant activity and a preparation method and application thereof. Background technique [0002] Oxygen free radicals are by-products of normal metabolism of aerobic biological cells, and about 1% of the daily oxygen ingested by the body produces oxygen free radicals. Under normal circumstances, the production and removal of oxygen free radicals in the human body are in a balanced state. When the balance is broken, excessive oxygen free radicals in the human body will cause biofilm peroxidation, DNA and protein damage, and enzyme inactivation, leading to human aging and tumors, etc. many diseases. The existing antioxidants on the market have the characteristics of large toxic side effects or instability. Therefore, it is necessary to develop more efficient, low-toxic and stable natural antioxidants. Contents of the invention [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/14C12P7/26C07C49/83C07C49/84A61P39/06A23L33/10A61K8/35A61Q19/08C12R1/645
Inventor 王斌贵李洪雷孟令红李晓明
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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