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A method for preventing wall sticking in the preparation of traditional Chinese medicine granules by spray drying

A traditional Chinese medicine and drying technology, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. Easy to stick wall effect

Active Publication Date: 2021-10-26
TONGHUA WANTONG PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the defect that the existing Chinese herbal medicine concentrate is spray-dried to prepare granules, it is easy to stick to the inner wall of the drying tower, and the present invention proposes a method for preventing wall sticking in the preparation of traditional Chinese medicine granules by spray drying

Method used

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  • A method for preventing wall sticking in the preparation of traditional Chinese medicine granules by spray drying

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Experimental program
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Effect test

Embodiment 1

[0029] A method of preventing adhesive walls in a spray drying agent particles, the specific method is as follows:

[0030] (1) Grind the Valley dice to the fine powder, over 100 mesh sieve, spare;

[0031] (2) Grind the agar to the fine powder, over 100 mesh sieve, spare;

[0032] (3) Take 100kg solid content of 15% mulberry concentrate to the stirred tank, then add 0.5 kg of step (1), the fine grain powder prepared, stirred at 50-100 rpm of rotational speed for 30 min, and the temperature of the stirred tank is 70. -80 ° C, so that the fine valley powder is evenly dispersed and ripe, and the osmium concentrate is concentrated, and the fine particles are fully adsorbed to the network structure of the cereal powder.

[0033] (4) Take the fine agar powder prepared by 0.3 kg step (2), add 2 kg of hot water to pre-dissolved, then add step (3), agitate, stir well;

[0034] (5) The material obtained by step (4) is continuously fed into the spray drying nozzle, and the first stage dryin...

Embodiment 2

[0038] A method of preventing adhesive walls in a spray drying, a method of preventing adhesive walls, and the specific method is as follows:

[0039] (1) Grind the Valley dice to the fine powder, over 100 mesh sieve, spare;

[0040] (2) Grind the agar to the fine powder, over 100 mesh sieve, spare;

[0041] (3) Take 100KG solid content of 20% of the macar concentrate to add a stirred tank, then the fine grain powder prepared by 0.8 kg of step (1), stirred at 50-100 rpm of rotational speed for 30 min, and the temperature of the stirred tank is 70. -80 ° C, make the fine valley powder uniformly dispersed and ripened, and the discharged from 24h, the soluble component in the concentrate of the Chinese medicine was concentrated, and the fine particles were fully adsorbed to the network structure of the cereal powder;

[0042] (4) Take the fine agar powder prepared by 0.5 kg step (2), add 2 kg of hot water to pre-dissolving, then add step (3), agitate the material, stir well;

[0043]...

Embodiment 3

[0047] A method of preventing adhesive walls in a spray drying, and the specific method is as follows:

[0048] (1) Grind the Valley dice to the fine powder, over 100 mesh sieve, spare;

[0049] (2) Grind the agar to the fine powder, over 100 mesh sieve, spare;

[0050] (3) Take 100kg solid content of 25% astragal concentrate to add a stirred tank, then the fine grain powder prepared by 0.5 kg step (1), stirred at 50-100 rpm of rotational speed for 40 min, and the temperature of the stirred tank is 70- 80 ° C, so that the fine valley powder is uniform and ripened, and the discharged from 24h, the soluble component in the concentrate of the Chinese medicine is concentrated, and the fine particles are fully adsorbed on the network structure of the cereal powder;

[0051] (4) Take the fine agar powder prepared by 0.3 kg step (2), add 4 kg of hot water to pre-dissolved, then add step (3), agitate the agitation, stir well;

[0052] (5) The material obtained by step (4) is continuously ...

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Abstract

The invention relates to the field of preparation of traditional Chinese medicine granules, in particular to a method for preventing wall sticking in preparation of traditional Chinese medicine granules by spray drying. This method takes advantage of the characteristics of the network formed by the ripening of glutinous rice flour, and fixes most of the soluble components in the concentrated Chinese medicine, such as sugars, in the network structure, thereby reducing the adhesion. After one step, agar colloid is used as a spacer , the colloid forms a film on the surface of the fine particles of the Chinese medicine concentrate and the grain powder that adsorbs the drug, and the agar colloid condenses into a jelly-like solid isolation film in the first-stage drying tower, and is dried at high temperature in the second-stage drying tower. The material is completely dried to form a solid film, and uniformly dispersed Chinese medicine granules are obtained. It not only effectively prevents the adhesion to the inner wall of the spray dryer drying tower, but also effectively isolates the bonding between the granules of the granule. It overcomes the defect that the granules of traditional Chinese medicine granules are easy to stick to the wall in the preparation of spray-drying.

Description

Technical field [0001] The present invention relates to the field of preparation of Chinese medicine granules, and more particularly to a method of preventing adhesive walls in a spray drying to prevent adhesive walls in Chinese medicine granules. Background technique [0002] With the gradual deep processing of traditional Chinese medicine, the processing, the traditional beverage film is difficult to meet the rapid demand of people, and the high concentration of Chinese medicine particle granules become the main choice for traditional Chinese medicine. Generally, the Chinese medicine granules are obtained by extracting the concentrate by Chinese medicine to obtain a spray drying technique. [0003] However, due to the special and complex Chinese medicine ingredients, there will be problems such as injection, adhesive walls, cakes, etc. during the concentrate of the traditional Chinese medicine, starch, and the like, and there will be problems such as nozzle, adhesive wall, cake...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K47/36A61K47/42A61K36/07A61K36/31A61K36/481A61K36/8988
Inventor 陈庆曾军堂
Owner TONGHUA WANTONG PHARMACY
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