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Acid-resistant Pulullan derivative, and preparation method thereof

A pullulan polysaccharide and derivative technology, applied in the chemical industry, can solve problems such as easy dissolution

Active Publication Date: 2018-01-05
INST OF MICROBIOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides an acid-resistant pullulan derivative and a preparation method thereof in order to solve the technical problem that existing products are easily dissolved under acidic conditions

Method used

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  • Acid-resistant Pulullan derivative, and preparation method thereof
  • Acid-resistant Pulullan derivative, and preparation method thereof
  • Acid-resistant Pulullan derivative, and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] 15g pullulan, 30g phthalic anhydride, 55g pyridine, 105ml N,N-dimethylformamide. When the temperature rises to 80°C, the timed reaction is started for 12h. After the completion of the reaction, the reaction solvent was evaporated in vacuum, and the product was poured into ice water for washing. Wash repeatedly until the wash solution is neutral. Filtration to obtain wet product, freeze-dried to obtain product. The structural infrared characterization of the product is as follows figure 1 As shown, the mass percentage of benzoic acid formyl group is 35%, and the pullulan derivative remains intact at low pH (pH=1.5-4), but dissolves at higher pH (pH=5-7).

Embodiment 2

[0031] 15g pullulan, 10g phthalic anhydride, 25g pyridine, 35ml N,N-dimethylformamide. When the temperature rises to 50°C, the timed reaction starts for 48h. After the completion of the reaction, the reaction solvent was evaporated in vacuum, and the product was poured into ice water for washing. Wash repeatedly until the wash solution is neutral. Filtration to obtain the wet product, drying at 40°C to obtain the product. The mass percentage of benzoic acid formyl group was 21%, and the pullulan derivative remained intact at low pH (pH=1.5-4.5), but dissolved at higher pH (pH=5-7).

Embodiment 3

[0033] 15g pullulan, 70g phthalic anhydride, 200g triethylamine, 250ml N,N-dimethylformamide. When the temperature rises to 60°C, the timed reaction is started for 24h. After the completion of the reaction, the reaction solvent was evaporated in vacuum, and the product was poured into ice water for washing. Wash repeatedly until the wash solution is neutral. Filtration to obtain wet product, freeze-dried to obtain product. The mass percentage of benzoic acid formyl group was 65%, and the pullulan derivative remained intact at low pH (pH=1.5-5), but dissolved at higher pH (pH=5-7).

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Abstract

The invention relates to an acid-resistant Pulullan derivative, and a preparation method thereof. The preparation method is used for solving a technical problem that a conventional product is easily dissolved at acidic conditions. The invention also discloses the structural formula and a preparation method of the acid-resistant Pulullan derivative. The preparation method can be widely used for preparation of acid-resistant Pulullan derivatives.

Description

technical field [0001] The invention relates to the field of chemical industry, in particular to an acid-resistant pullulan derivative and a preparation method thereof. Background technique [0002] Pullulan is an extracellular polysaccharide produced by fermentation of A. sporogenes. Maltotriose is bound by α-1,4 glycosidic bonds, and the two ends are repeatedly connected with another maltotriose by α-1,6 glycosidic bonds. The high molecular linear polysaccharide. Pullulan is safe, non-toxic, non-immunogenic, non-teratogenic, has many advantages such as good biocompatibility and biodegradability, and is an excellent biological material used in drug delivery systems and biological tissue engineering. and other fields. [0003] Pullulan has good film-forming properties, and the film-forming permeability is low, and oxygen, nitrogen, carbon dioxide and other gases can hardly pass through, so it is used in the preparation of vegetable capsules. Compared with other capsules, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/02
Inventor 高启合晏礼明
Owner INST OF MICROBIOLOGY - CHINESE ACAD OF SCI
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