Preservative and bactericidal agent for broad-spectrum daily chemicals

A technology of antiseptic and fungicides, products, applied in the direction of fungicides, biocides, biocides, etc., can solve the problems of low antiseptic safety, increased risk of using preservatives, breast diseases, etc., and achieve high efficiency and low toxicity fungicide Ability, broad-spectrum anti-corrosion and anti-mildew ability, excellent bactericidal and anti-corrosion effect

Active Publication Date: 2018-01-05
SHAANXI RES DESIGN INST OF PETROLEUM CHEM IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Parabens, a preservative used in traditional daily chemicals, can cause endocrine disorders and lead to breast diseases; the controversy over triclosan’s carcinogenicity led to the European Union’s announcement in January 2014 to officially ban the use of triclosan in daily chemical products; The report of quaternary ammonium salt-15 and formaldehyde in children's bathroom products also warned of the increased risk of the use of traditional preservatives, causing worldwide panic
On July 22, 2016, the European Commission revised the EU cosmetics EC 1223 / 2009 on the management of methylisothiazolinone: when methylisothiazolinone is used as a cosmetic preservative, it can only be used in rinse-off cosmetics, The maximum allowable use concentration is 0.01%, and recently there is a trend of reducing its use to 0.0015%, which makes the use of traditional excellent preservatives face a great crisis, especially the almost vacant phenomenon of antifungal agents
However, the "zero additive" preservatives are relatively used in a large amount, and the anti-corrosion safety is not high, which is easy to cause anti-corrosion failure
The use of purely traditional preservatives has almost no market in the field of daily chemicals

Method used

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  • Preservative and bactericidal agent for broad-spectrum daily chemicals
  • Preservative and bactericidal agent for broad-spectrum daily chemicals
  • Preservative and bactericidal agent for broad-spectrum daily chemicals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation method of a kind of broad-spectrum daily chemical product antiseptic bactericide of the present invention comprises following processing steps:

[0037] 1. Heat 69.7 kg of benzyl alcohol and 20 kg of sorbitan caprylate to 40°C and stir to dissolve;

[0038] 2. Add 10 kg of chlorphenesin into the above mixture and stir to make it completely dissolved, and finally add 0.3 kg of iminodisuccinic acid to dissolve, and filter to obtain the invented broad-spectrum daily chemical product antiseptic and fungicide.

Embodiment 2

[0040] 1. Heat 64.8 kg of benzyl alcohol and 20 kg of sorbitan caprylate to 40°C and stir to dissolve;

[0041] 2. Add 15 kg of chlorphenesin into the above mixture and stir to make it completely dissolved, finally add 0.2 kg of iminodisuccinic acid to dissolve, and filter to obtain the invented broad-spectrum daily chemical product antiseptic and fungicide.

Embodiment 3

[0042] Embodiment 3 (compared with Embodiment 1)

[0043] The implementation method is according to Example 1, except that the iron ion chelating agent iminodisuccinic acid is not added, compared with Example 1, and the antibacterial effect on microorganisms is observed.

[0044] Implementation Effect

[0045] Synergy between each component: Table 1 is the minimum inhibitory concentration of each component. Pa = Pseudomonas aeruginosa, Sa = Staphylococcus aureus, Ab = Aspergillus niger.

[0046] Table 1. Minimum inhibitory concentrations of relevant components

[0047]

[0048]According to the calculation method of synergy coefficient SI described in "Applied Microbiology" in 1961 such as Kull E.C.:

[0049] SI=Qa / QA+Qb / QB

[0050] QA—minimum inhibitory concentration of preservative A alone

[0051] QB---The minimum inhibitory concentration of preservative B alone

[0052] Qa—the concentration of A at the minimum inhibitory concentration of mixed preservatives (that i...

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PUM

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Abstract

The invention relates to a preservative and bactericidal agent for broad-spectrum daily chemicals, which is prepared from the following substances in percentage by weight: 8 to 16 percent of chlorphenesin, 55 to 75 percent of benzyl alcohol, 15 to 30 percent of sorbitan caprylate and 0.1 to 0.5 percent of additive. The preservative and bactericidal agent is compounded by adopting a variety of zero-added preservatives with different bactericidal mechanisms and antibacterial spectra complementing one another and a conventional preservative, and has the advantages of reasonable concerted application, full protection, strong synergism, toxicological safety, good bactericidal and preservative effects and the like. Practice proves that the effect of use in the daily chemicals is good.

Description

technical field [0001] The invention belongs to the technical field of preparation of chemical antiseptic and antifungal agents, and in particular relates to an antiseptic and antiseptic agent for broad-spectrum daily chemical products. Background technique [0002] Daily chemical products are daily necessities that are closely related to people's lives, and they are also an area where people are extremely concerned about their toxicity and safety, and the preservatives in them are the focus of attention. [0003] Parabens, a preservative used in traditional daily chemicals, can cause endocrine disorders and lead to breast diseases; the controversy over triclosan’s carcinogenicity led to the European Union’s announcement in January 2014 to officially ban the use of triclosan in daily chemical products; The reports of quaternary ammonium salt-15 and formaldehyde in children's bathroom products also warned of the increased risk of the use of traditional preservatives, causing ...

Claims

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Application Information

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IPC IPC(8): A01N43/08A01N31/14A01N31/04A01P1/00A01P3/00
Inventor 李程碑杨俊伟杨淑玮曹琳
Owner SHAANXI RES DESIGN INST OF PETROLEUM CHEM IND
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