Elastic silica gel strip for scar treatment and preparation method thereof

A technology of scar sticking and silicone gel, which is applied in the field of medical supplies, can solve problems such as long time, failure to achieve results, long-term effect of scars, etc., and achieve the effect of promoting scar repair

Pending Publication Date: 2017-12-26
HENAN HUIBO MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the promotion layer and silicone layer of this patent can only act on the scar through slow drug release, and the time for the drug to reach the scar is long and the concentration is small, which requires a long period of action for the recovery of the scar; and the patented product acts on the scar. The pressure on the scar is fixed by the elastic band to achieve the effect. If the pressure is too high during the operation, it will easily damage the skin of the scar. If the pressure is too small, the effect will not be achieved. The pressure of the elastic band cannot be monitored and adjusted in real time, which is not convenient and intelligent enough

Method used

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  • Elastic silica gel strip for scar treatment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The medical silicone gel of the silicone gel elastic scar patch in this embodiment is prepared from the following raw materials in parts by weight: 35 parts of polydimethylsiloxane, 15 parts of cyclopentasiloxane, 5 parts of silicon dioxide, 5 parts of catalyst, 5 parts of acetic acid;

[0052] The medicine embedded in chitosan-lecithin microparticles embedded with medicine is composed of the following raw materials in parts by weight: 5 parts of centella asiatica extract, 0.5 part of low molecular weight sodium hyaluronate, and 5 parts of glycerin.

[0053] The preparation method of the silicone gel elastic scar patch of this embodiment is characterized in that it comprises the following steps:

[0054] 1) Preparation of acidic medical silicone gel: Mix polydimethylsiloxane, cyclopentasiloxane, silicon dioxide, and acetic acid in proportions by weight and stir evenly, then add catalyst, mix and stir evenly again, and use ultrasonic method Remove air bubbles to obtain ...

Embodiment 2

[0061] The medical silicone gel of the silicone gel elastic scar patch in this embodiment is prepared from the following raw materials in parts by weight: 20 parts of polydimethylsiloxane, 10 parts of cyclopentasiloxane, 2 parts of silicon dioxide, 1 part of catalyst, 3 parts of acetic acid;

[0062] The medicine embedded in chitosan-lecithin particle is composed of the following raw materials in parts by weight: 10 parts of centella asiatica extract, 2 parts of low molecular weight sodium hyaluronate and 10 parts of glycerin.

[0063] The difference between the preparation method of the silicone gel elastic scar patch of this embodiment and embodiment 1 is that the mass percentage concentration of chitosan acetic acid solution is 2% in step B; the mass concentration of lecithin in the lecithin solution is 20g / L 1. The mass concentration of the drug to be embedded is 5mg / mL; the volume ratio of chitosan acetic acid solution to lecithin ethanol solution is 1:6; the dosage of em...

Embodiment 3

[0065] The medical silicone gel of the silicone gel elastic scar patch in this embodiment is prepared from the following raw materials in parts by weight: 50 parts of polydimethylsiloxane, 20 parts of cyclopentasiloxane, 8 parts of silicon dioxide, 10 parts of catalyst, 8 parts of acetic acid;

[0066] The medicine embedded in chitosan-lecithin microparticles with medicine is composed of the following raw materials in parts by weight: 7 parts of centella asiatica extract, 1 part of low-molecular-weight sodium hyaluronate, and 7.5 parts of glycerin.

[0067] The difference between the preparation method of the silicone gel elastic scar patch of this embodiment and embodiment 1 is that the mass percentage concentration of chitosan acetic acid solution is 2% in step B; the mass concentration of lecithin in the lecithin solution is 20g / L 1. The mass concentration of the drug to be embedded is 5mg / mL; the volume ratio of chitosan acetic acid solution to lecithin ethanol solution is...

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Abstract

The invention relates to the technical field of medical supplies, in particular to an elastic silica gel strip for scar treatment and a preparation method thereof. According to the elastic silica gel strip for scar treatment, the side close to the surface of a wound is regarded as an inner layer, and the elastic silica gel strip for scar treatment comprises a medical silicone gel layer, a hydrophilic gauze layer, a medical sponge layer loaded with a medicine body through maceration and an elastic backing layer from inside to outside in sequence; an air bag is placed in the medical sponge layer loaded with the medicine body through maceration, and the air bag is connected with an air charging device; the medicine body in which the medical sponge layer is macerated comprises chitosan-lecithin nano particles embedded with a medicine; acidic medical silicone gel is adopted as the material of the medical silicone gel layer. On one hand, by means of the hydrophilic gauze layer, transferring of the medicine particles to the gel layer is promoted, on the other hand, by means of the acidic silicone gel, embedding undoing of the medicine particles and releasing of the medicine to skin of a scar are promoted, and the scar is activated and repaired; meanwhile, through double effects of the hydrophilic gauze layer and chitosan, a moist thin film is provided for the scar, and water is provided, so that discomfort such as drying and pruritus of the skin of the scar is alleviated.

Description

technical field [0001] The invention relates to the technical field of medical supplies, in particular to a silicone gel elastic scar patch and a preparation method thereof. Background technique [0002] Scar is a change in the appearance, morphology and histopathology of normal skin tissue caused by various traumas. The formation of scars is an inevitable product in the process of wound repair. Clinically, patients often leave severe scars after wound healing, especially hypertrophic scars are very common. Hypertrophic scars are formed due to excessive growth of fibroblasts and excessive deposition of proteoglycans, glycoproteins, and collagen in the extracellular matrix. A large number of clinical studies have shown that skin tissue tension plays a key role in the formation of wound scars. The greater the tension, the greater the possibility of scar formation after wound healing. Therefore, by reducing the tension of the skin tissue around the scar, it can effectively re...

Claims

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Application Information

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IPC IPC(8): A61M37/00A61L15/44A61L15/42A61L15/28A61L15/20A61L15/24A61L15/26A61L15/18
CPCA61L15/18A61L15/20A61L15/24A61L15/26A61L15/28A61L15/42A61L15/425A61L15/44A61M37/00A61L2400/12A61L2300/25A61L2300/30A61L2300/412A61M2037/0007C08L5/08C08L83/04C08L23/12C08L1/02
Inventor 曹晶晶周新钦张艳琦李延浩彭克林
Owner HENAN HUIBO MEDICAL CO LTD
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