Method for recovering cefprozil from cefprozil crystallization mother liquor

Abstract

The invention discloses a method for recovering cefprozil from cefprozil crystallization mother liquor. The method is characterized in that the absorption, desorption and crystallization treatment is performed on the cooled cefprozil crystallization mother liquor by adopting macro-porous resin, and the purified cefprozil is recovered. The method comprises the following steps: by utilizing the macro-porous resin, in combination with the cooperation of the adsorption conditions of specific pH, temperature and flow rate and the desorption conditions of certain pH, temperature and flow rate of a specific analytical solution, effectively absorbing and efficiently desorbing the cefprozil remaining in the efprozil crystallization mother liquor through the macro-porous resin and recovering; finally de-coloring, crystallizing, filtering and drying the analytical solution to obtain a high-purity cefprozil product conforming to qualified product standard requirements. The method disclosed by the invention is high in recovery rate, simple and convenient to cooperate, low in cost, green and safe; and the residue of the cefprozil in the cefprozil crystallization mother liquor after recovery treatment is less than or equal to 1 mg / ml, so that the COD value of wastewater can be effectively reduced, and the environmental protection pressure and the wastewater treatment cost are reduced, and therefore, the economic and social benefits are significant.

Description

technical field [0001] The invention relates to the technical field of cefprozil recovery, in particular to a method for recovering cefprozil from cefprozil crystallization mother liquor. Background technique [0002] Cefprozil, chemical name (6R,7R)-7-[(R)-2-amino-2-(p-hydroxy-phenyl)acetamido]-8-oxo-3-propene-5-thia-1 -Azabicyclo-(4,2,0)oct-2-ene-2-carboxylic acid monohydrate is a second-generation cephalosporin antibiotic with broad-spectrum antibacterial activity, and it is effective against Gram-positive aerobic bacteria Staphylococcus aureus (including β-lactamase-producing strains), Streptococcus pneumoniae, and Streptococcus pyogenes have obvious effects on Staphylococcus aureus, Listeria monocytogenes, Staphylococcus epidermidis, Staphylococcus saprophyticus, Staphylococcus Warnei has a certain inhibitory effect. It is clinically used for upper respiratory tract infection (such as pharyngitis, tonsillitis), lower respiratory tract infection (acute bronchitis, acut...

AI Technical Summary

Problems solved by technology

There is a certain amount of cefprozil remaining in the crystallization mother liquor. If it is not recycled and directly discharged to environmental protection treatment, it will not only cause huge waste, but also generate huge COD, which will put pressure on environmental protection and significantly increase the cost of environmental protection treatment.

In the prior art, the method of recovering sporepropene from the crystallization mother liquor generally needs to use a large amount of reagents to complete a series of extraction and purification steps, such as Chinese patent ZL201210383705.7, the recovery operation is complicated, and the organic solvents that need to be used are many and the amount is large , Correspondingly bring troubles to solvent recovery treatment and environmental protection, so more optimized technology for recovering cefprozil from cefprozil crystallization mother liquor is needed to simplify operation, reduce production cost, and provide safer and green production

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