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Dual-component soluble hydrogel dressing and its preparation method

A soluble, hydrogel technology, applied in bandages, medical science and other directions, can solve the problems of poor wound fit, patient pain, secondary injury, etc., to effectively seal wounds, reduce patient pain, and have strong plasticity.

Active Publication Date: 2017-12-22
SHANDONG ZHUSHI PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing wound dressings, including hydrogel dressings, are mostly in solid form, and there are many problems in the process of use, such as poor adhesion to the wound, easy infection of the wound, difficult treatment of shaped wounds, and easy to cause secondary damage. Inherent flaws in morphological dressings
Especially for patients with severe burns, manual mechanical replacement of dressings and debridement are still required during wound care, which will inevitably cause trauma to the new epithelial tissue, delayed healing and patient pain

Method used

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  • Dual-component soluble hydrogel dressing and its preparation method
  • Dual-component soluble hydrogel dressing and its preparation method
  • Dual-component soluble hydrogel dressing and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Mix 100g of N-acryloxy succinimide, 300g of thioglycolic acid, 10g of N,N-diisopropylethylamine, and 500g of dichloroethane, stir and react at room temperature for 24h to obtain a mixture; then, use 10% chlorine The mixture was washed with sodium chloride solution, the organic layer was dried with sodium sulfate, the solvent was evaporated, and the residue was purified by precipitation in ether to obtain an intermediate (yield=90%); 100g intermediate, 200g N-Hydroxythiosuccinimide NHS, 50g dicyclohexylcarbodiimide DCC, 300g dichloromethane DCM were mixed, the reaction was stirred at 30°C for 24h, the precipitate was filtered, the solvent was evaporated, and the residue was dissolved in ether Precipitation in the medium to obtain monomer B (yield=90%).

Embodiment 2

[0030] Mix 100g of N-acryloxysuccinimide, 50g of thioglycolic acid, 50g of N,N-diisopropylethylamine, and 500g of dichloroethane, stir and react at room temperature for 12h to obtain a mixture; then, use 10% chlorine The mixture was washed with sodium chloride solution, the organic layer was dried with sodium sulfate, the solvent was evaporated, and the residue was purified by precipitation in ether to obtain an intermediate (yield=92%); 100g intermediate, 500g N-Hydroxythiosuccinimide NHS, 500g dicyclohexylcarbodiimide DCC, 1000g dichloromethane DCM were mixed, and the reaction was stirred at 0°C for 24h, the precipitate was filtered, the solvent was evaporated, and the residue was dissolved in ether Precipitation in the medium to obtain monomer B (yield=91%).

Embodiment 3

[0032] Mix 100g of N-acryloxysuccinimide, 500g of thioglycolic acid, 3g of N,N-diisopropylethylamine and 100g of dichloromethane, stir and react at room temperature for 2~24h to obtain a mixture; then, use 10% chlorine The mixture was washed with sodium chloride solution, the organic layer was dried with sodium sulfate, the solvent was evaporated, and the residue was purified by precipitation in ether to obtain the intermediate (yield=95%); 100g intermediate, 50gN -Hydroxythiosuccinimide NHS, 100g dicyclohexylcarbodiimide DCC, 500g dichloromethane DCM were mixed, stirred for 2h at 50℃, filtered the precipitate, evaporated the solvent, and put the residue in ether Precipitation to obtain monomer B (yield=96%).

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PUM

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Abstract

The invention discloses a dual-component soluble hydrogel dressing and its preparation method. The soluble hydrogel dressing is prepared by curing dual-component water solution under an ambient temperature condition and dissolved under the effect of specific dissolving agent. The soluble hydrogel dressing has the advantages of being strong in plasticity, good in binding property and able to effectively seal wound; the soluble hydrogel dressing can be dissolved in suitable solvent, and is very convenient to replace without mechanical peeling; besides, for the soluble hydrogel dressing cannot peel the healing wound to cause the secondary injury, the pain of a patient is lightened.

Description

Technical field [0001] The invention relates to a hydrogel dressing and a preparation method thereof, in particular to a two-component hydrogel dressing with solubility and a preparation method thereof. Background technique [0002] Traditional wound dressings are composed of natural plant fibers or animal hair materials, such as gauze, cotton pads, wool, various oil gauze, etc. These dressings are only temporary covering materials and need to be replaced within a certain period of time. However, these wound dressings are prone to stick to the wound when they are replaced. Therefore, the new epithelial cells or the gradually healed wounds may be torn at the same time as the dressing is removed. It is not conducive to the natural healing of the wound. [0003] The hydrogel medical dressing is a new type of wound dressing developed in recent years. Compared with the traditional gauze dressings used in clinical practice, the hydrogel dressing can shorten the wound healing time, reduc...

Claims

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Application Information

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IPC IPC(8): A61L26/00C08F283/06C08F220/28C08F220/38C08F220/58C08F220/56C08F226/10
CPCA61L26/00A61L26/0014A61L26/0019A61L26/0061A61L26/008C08F220/38C08F220/58C08F226/10C08F283/065A61L2300/412C08F220/387C08F220/585C08L51/08C08L33/24C08L33/14C08L39/06C08L71/02C08L77/02C08F220/56C08F220/281
Inventor 刘云晖彭新艳
Owner SHANDONG ZHUSHI PHARMA GRP CO LTD
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