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Application of herba houttuyniae extracts to preparation of medicine preparation for preventing and treating related diseases of myocardial ischemia reperfusion injury

An extract of Houttuynia cordata and a technology for reperfusion injury, which are applied in the field of biomedicine to achieve the effects of reducing myocardial infarction area, huge clinical application value, and reducing myocardial ischemia-reperfusion injury.

Active Publication Date: 2017-12-22
深圳市龙华区中心医院
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the research on the effect of Houttuynia volatile oil on myocardial ischemia-reperfusion injury has not been reported. In this research, we found that Houttuynia volatile oil has obvious protection against myocardial ischemia-reperfusion injury. It can be used as a drug for clinical prevention and treatment of myocardial ischemia-reperfusion related diseases

Method used

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  • Application of herba houttuyniae extracts to preparation of medicine preparation for preventing and treating related diseases of myocardial ischemia reperfusion injury
  • Application of herba houttuyniae extracts to preparation of medicine preparation for preventing and treating related diseases of myocardial ischemia reperfusion injury
  • Application of herba houttuyniae extracts to preparation of medicine preparation for preventing and treating related diseases of myocardial ischemia reperfusion injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Study on the protective effect and mechanism of Houttuynia volatile oil on myocardial ischemia-reperfusion injury in rats

[0026] 1. Materials

[0027] 1.1 Instrument

[0028] DGG-9070B electric blast drying oven (Shanghai Senxin Experimental Instrument Co., Ltd.); HC-280T2 universal pulverizer (Yongkang Lvke Food Machinery Co., Ltd.); rotary evaporator (Shanghai Yarong Biochemical Instrument Factory); BL-420F Biological function experiment system (Chengdu Taimeng Technology Co., Ltd.); RM2255 Lycra slicer (German Lycra Instrument Company); HX-101E animal ventilator (Shanghai Alcott Biotechnology Co., Ltd.)

[0029] 1.2 Drugs and reagents

[0030] Dexamethasone tablets: specification 0.75mg / tablet, Guangdong South China Pharmaceutical Group Co., Ltd.; Houttuynia cordata: Guangdong Tiantai Pharmaceutical Co., Ltd.; creatine kinase (CK), lactate dehydrogenase (LDH), superoxide dismutation Enzyme (SOD), malondialdehyde (MDA) detection kit: Nanjing Jiancheng C...

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Abstract

The invention relates to the field of biological medicine, in particular to application of herba houttuyniae extracts to preparation of a medicine preparation for preventing and treating related diseases of myocardial ischemia reperfusion injury. The herba houttuyniae is herb of houttuynia cordata Thunb., and is prepared into a soft capsule through the processes of freezing, pulverization, soaking, filtration, concentration and the like or is prepared into a preparation for clinical application according to a pharmacy process. The herba houttuyniae extract preparation can obviously reduce the myocardial infarction area of a myocardial ischemia reperfusion injury rat; and the result shows that the herba houttuyniae extract preparation has the obvious prevention and treatment effects on the related diseases of the myocardial ischemia reperfusion injury, and can be used as functional food or medicine for preventing and treating the related diseases of the myocardial ischemia reperfusion injury of the human body.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of houttuynia cordata extract in the preparation of pharmaceutical preparations for preventing and treating diseases related to myocardial ischemia-reperfusion injury. Background technique [0002] Myocardial ischemic disease, also known as coronary heart disease, is one of the most common and frequent cardiovascular system diseases. About 23.5 million people die from coronary heart disease every year in the world, and the fatality rate of myocardial infarction accounts for the second place. Myocardial infarction is a disease mainly caused by the reduction or interruption of coronary blood supply, which leads to ischemia and hypoxia of myocardial cells, and finally causes myocardial cell necrosis. At present, the main clinical treatment approach is to restore the blood flow of ischemic myocardium as soon as possible, increase blood flow, improve microcirculation, etc. t...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61P9/10A23L33/105
CPCA23V2002/00A61K36/78A61K2236/15A61K2236/331A23L33/105A23V2200/326A23V2250/21
Inventor 李少金司徒永立方婉仙肖水秀张肄鹏
Owner 深圳市龙华区中心医院
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