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Quick reaction technology and production system for deflazacort

A technology of Diflucort and production system, which is applied in the field of Diflucort rapid response process and production system, can solve problems such as poor fluidity of raw materials, long chemical reaction time, and low production efficiency, so as to improve sealing performance and improve production Purity, the effect of improving production safety

Active Publication Date: 2017-12-12
YUEYANG HUANYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the traditional production of deflazacort, due to the need for multi-step chemical reactions for production, and the poor fluidity of raw materials in the reaction solution, each chemical reaction takes a long time, resulting in a very long production time of deflazacort and low production efficiency. low

Method used

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  • Quick reaction technology and production system for deflazacort
  • Quick reaction technology and production system for deflazacort
  • Quick reaction technology and production system for deflazacort

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Preparation of oxides: Add 80 parts of mold dehydrogenation products, 150 parts of glacial acetic acid, 20 parts of chromic anhydride, and 8 parts of manganese acetate into the reactor, maintain the temperature in the reactor at 35-38°C, and control the rotation speed of the stirring shaft of the reactor from 30 -180r / min alternate transformation, wherein the lowest speed lasts for 5 minutes each time, and the highest speed lasts for 2 minutes each time. After stirring and reacting for 2 hours, add 1500 parts of sodium hydroxide solution with a mass percentage concentration of 5.4% for water analysis. , to obtain oxides by centrifugal filtration;

[0085] The reaction formula is:

[0086]

[0087] Preservation preparation: Add 80 parts of the oxide, 30 parts of glacial acetic acid, 1200 parts of water, and 20 parts of methyl carbazate into the reactor, control the temperature of the reactor to 20-25°C, and control the rotation speed of the stirring shaft of the react...

Embodiment 2

[0103] Preparation of oxides: Add 120 parts of mold dehydrogenation products, 250 parts of glacial acetic acid, 50 parts of chromic anhydride, and 20 parts of manganese acetate into the reactor, maintain the temperature in the reactor at 35-38°C, and control the rotation speed of the stirring shaft of the reactor from 30 -180r / min alternate transformation, wherein the lowest speed lasts for 5 minutes each time, and the highest speed lasts for 2 minutes each time. After stirring and reacting for 3 hours, add 2000 parts of sodium hydroxide solution with a mass percentage concentration of 5.4% for water analysis. , to obtain oxides by centrifugal filtration;

[0104] Preservation preparation: Add 100 parts of the oxide, 70 parts of glacial acetic acid, 2000 parts of water, and 60 parts of methyl carbazate into the reactor, control the temperature of the reactor to 20-25°C, and control the rotation speed of the stirring shaft of the reactor by 30-240r / min alternation, wherein the ...

Embodiment 3

[0112] Preparation of oxides: Add 100 parts of mold dehydrogenation products, 200 parts of glacial acetic acid, 40 parts of chromic anhydride, and 14 parts of manganese acetate into the reactor, maintain the temperature in the reactor at 35-38°C, and control the rotation speed of the stirring shaft of the reactor from 30 -180r / min alternating transformation, wherein the lowest speed lasts for 5 minutes each time, and the highest speed lasts for 2 minutes each time. After stirring and reacting for 2-3 hours, add 1650 parts of sodium hydroxide solution with a concentration of 5.4% in mass percent for water After analysis, the oxide was obtained by centrifugal filtration;

[0113] Preservation preparation: Add 98 parts of the oxide, 50 parts of glacial acetic acid, 1500 parts of water, and 40 parts of methyl carbazate into the reactor, control the temperature of the reactor to 20-25°C, and control the rotation speed of the stirring shaft of the reactor by 30-240r / min alternation,...

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Abstract

The invention discloses a quick reaction technology and a production system for deflazacort. The production system comprises a reaction kettle, an elutriation kettle, centrifugal filtering equipment, a concentration kettle, drying equipment and a discoloring kettle which are mutually connected according to procedures, wherein the reaction kettle comprises a tank body, and an interlayer cavity is arranged at the outer wall of the tank body; a temperature adjusting tube is arranged in the tank body; a stirring shaft is arranged at the center of the interior of the tank body; the upper end of the stirring shaft is connected with a magnetic coupling rotary device, and a stirring impeller is arranged at the lower end of the stirring shaft; a rotary cylinder is arranged on the stirring shaft; a buoyancy impeller is arranged on the rotary cylinder; a lifting tray is arranged at the upper end of the buoyancy impeller; a circular hole is formed in the lifting tray; water filtering holes are uniformly distributed in the lifting tray; a vertical slide groove is arranged in the outer wall of the rotary cylinder; a rolling shaft is arranged at the inner wall of a base of the buoyancy impeller; an upper key board is arranged at the upper end of a rotary cover of the stirring impeller; a lower key board is arranged at the lower end of the rotary cylinder. The production system and the technology have the advantages that the multi-azimuth flowing of reaction liquid is realized, the reaction time of the deflazacort in each step is shortened, and the quick production of the deflazacort is realized.

Description

technical field [0001] The invention belongs to the technical field of chemical industry, and specifically relates to a deflazacort rapid reaction process and production system. Background technique [0002] Deflazacort is mainly used as corticosteroid pharmaceutical raw materials and intermediates. It is a white or off-white crystalline powder with anti-inflammatory and anti-allergic effects, which is 10 to 20 times equivalent to prednisolone. It is used for adrenal cortex function decline, autoimmune diseases, allergic diseases and blood system diseases, etc. During the traditional production of deflazacort, due to the need for multi-step chemical reactions for production, and the poor fluidity of raw materials in the reaction solution, each chemical reaction takes a long time, resulting in a very long production time of deflazacort and low production efficiency. low. Contents of the invention [0003] One object of the present invention is to address the above problem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J71/00
CPCC07J71/0068
Inventor 徐润星
Owner YUEYANG HUANYU PHARMA
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