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Golden eriodictine-7-o-β-d-glucuronate methyl ester and its extraction method and application

A technology of golden elycoprine and methyl aldol, applied in chemical instruments and methods, sugar derivatives, sugar derivatives, etc., can solve the problem of reducing blood sugar levels in alloxan-induced diabetic mice and adrenergic diabetic mice , anti-type 2 diabetes active ingredients and other problems, to achieve the extraction method is simple and easy, good blood sugar lowering effect, the effect of high extraction rate

Inactive Publication Date: 2020-08-14
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, Triangularia research has attracted widespread attention at home and abroad. The research group has carried out basic research on Triangularia and found that the total ethanol extract of Triangularia can significantly reduce blood sugar in alloxan-induced diabetic mice and adrenaline-induced diabetic mice. Value; fed with high-fat and high-sugar feed combined with intraperitoneal injection of small doses of streptozotocin (STZ) to establish a type 2 diabetes rat model, and determined that the site with the strongest anti-type 2 diabetes activity was n-butanol, but its anti-type 2 diabetes The research on the active ingredients and mechanism of diabetes mellitus is quite shallow

Method used

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  • Golden eriodictine-7-o-β-d-glucuronate methyl ester and its extraction method and application
  • Golden eriodictine-7-o-β-d-glucuronate methyl ester and its extraction method and application
  • Golden eriodictine-7-o-β-d-glucuronate methyl ester and its extraction method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A kind of gold sage rhizoflavin-7-O-β-D-glucuronic acid methyl ester, the structural formula of the gold sage rhizoflavin-7-O-β-D-glucuronic acid methyl ester is:

[0028]

[0029] A method for extracting gold sage grass xanthin-7-O-β-D-glucuronic acid methyl ester, comprising the following steps:

[0030] 1) Using triangular foam coarse powder as raw material, ethanol as solvent, extracting by percolation method to obtain ethanol extract, and recovering ethanol solvent to obtain the first extract;

[0031] 2) Add water to the first extract to form a suspension, add petroleum ether, ethyl acetate, and n-butanol to the suspension in sequence for extraction, and concentrate the n-butanol extract to form an extract as the second extract ;

[0032] 3) Take the second extract, perform polyamide column chromatography, use water-ethanol as the eluent, perform gradient elution, collect the eluent of 50% ethanol water, and concentrate the 50% ethanol water eluent to obtain Extract, as ...

Embodiment 2

[0040] A kind of gold sage rhizoflavin-7-O-β-D-glucuronic acid methyl ester, the structural formula of the gold sage rhizoflavin-7-O-β-D-glucuronic acid methyl ester is:

[0041]

[0042] A method for extracting gold sage grass xanthin-7-O-β-D-glucuronic acid methyl ester, comprising the following steps:

[0043] 1) Using triangular foam coarse powder as raw material, ethanol as solvent, extracting by percolation method to obtain ethanol extract, and recovering ethanol solvent to obtain the first extract;

[0044] 2) Add water to the first extract to form a suspension, add petroleum ether, ethyl acetate, and n-butanol to the suspension in sequence for extraction, and concentrate the n-butanol extract to form an extract as the second extract ;

[0045] 3) Take the second extract, perform polyamide column chromatography, use water-ethanol as the eluent, perform gradient elution, collect the eluent of 50% ethanol water, and concentrate the 50% ethanol water eluent to obtain Extract, as ...

Embodiment 3

[0053] A kind of gold sage rhizoflavin-7-O-β-D-glucuronic acid methyl ester, the structural formula of the gold sage rhizoflavin-7-O-β-D-glucuronic acid methyl ester is:

[0054]

[0055] A method for extracting gold sage grass xanthin-7-O-β-D-glucuronic acid methyl ester, comprising the following steps:

[0056] 1) Using triangular foam coarse powder as raw material, ethanol as solvent, extracting by percolation method to obtain ethanol extract, and recovering ethanol solvent to obtain the first extract;

[0057] 2) Add water to the first extract to form a suspension, add petroleum ether, ethyl acetate, and n-butanol to the suspension in sequence for extraction, and concentrate the n-butanol extract to form an extract as the second extract ;

[0058] 3) Take the second extract, perform polyamide column chromatography, use water-ethanol as the eluent, perform gradient elution, collect the eluent of 50% ethanol water, and concentrate the 50% ethanol water eluent to obtain Extract, as ...

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Abstract

The invention discloses a chrysoeriol-7-O-beta-D glucuronic acid methyl ester. The structural formula of the chrysoeriol-7-O-beta-D glucuronic acid methyl ester is disclosed in the following diagram. The invention also discloses an extraction method for the chrysoeriol-7-O-beta-D glucuronic acid methyl ester and the application of the chrysoeriol-7-O-beta-D glucuronic acid methyl ester for preparing antioxidant medicines, antioxidant cosmetics, hypoglycemic drugs or antitumor drugs.

Description

Technical field [0001] The invention relates to a compound and its extraction method and application. More specifically, the present invention relates to a golden sage grass flavin-7-O-β-D-glucuronic acid methyl ester and its extraction method and use. Background technique [0002] Triangulum is the dry whole plant of Cardiospermum halicacabum L. (Cardiospermum halicacabum L.), also known as fake bitter gourd and sailboat. Mainly distributed in Guangdong, Guangxi, Fujian, Taiwan and other places, it tastes pungent and cold, has the effects of clearing heat, diuresis, cooling blood, removing blood stasis, and detoxification. It is mostly used to treat pneumonia, jaundice, gonorrhea, boils, rheumatism, and bruises. Injuries, snake and insect bites, etc. Modern pharmacological studies have shown that the triangular bubble has anti-inflammatory, antioxidant, analgesic, antipyretic, anti-malaria, antidiarrheal, diuretic, anti-diabetic, anti-convulsant, and anti-anxiety effects. In ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/07C07H1/08A61K8/60A61P39/06A61P3/10A61P35/00A61Q19/08
CPCA61K8/602A61Q19/08C07H1/08C07H17/07
Inventor 卢汝梅韦建华李兵朱小勇黄志其曾艳婷
Owner GUANGXI UNIV OF CHINESE MEDICINE
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