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Pharmaceutical novel applications of acyclovir in reducing toxicity of irinotecan

A technology of irinotecan and its use, which can be applied to medical preparations containing active ingredients, pharmaceutical formulations, antitumor drugs, etc., and can solve problems such as increasing the physique of tumor patients

Inactive Publication Date: 2017-12-08
BINZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is mainly used for various infections caused by herpes simplex virus, and can be used for initial or recurrent skin, mucous membrane, external genital infection and herpes simplex virus (HSV) infection in immunocompromised patients, but anti-HSV drugs Ciclovir is used in combination with the antineoplastic drug irinotecan or its active metabolite 7-ethyl-10 hydroxycamptothecin (SN-38) to prevent or treat the toxicity of irinotecan or SN-38, and reduce the Diarrhea caused by rinotecan or SN-38, reduce the decrease in diet due to intestinal dysfunction caused by diarrhea, increase the physique of tumor patients, improve the tolerance of irinotecan or SN-38 dosage in tumor patients, and prolong the use of tumor patients No effect of irinotecan or SN-38 timing was reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0006] Experimental Example 1 The Effect of Acyclovir on the Toxicity Caused by Irinotecan Administration

[0007] 1.1 Drugs and reagents

[0008] Acyclovir (purity 99.3%, purchased from Shanghai Hanxiang Biotechnology Co., Ltd.)

[0009] Irinotecan hydrochloride (purity 99.5%, purchased from Shanghai Hanxiang Biotechnology Co., Ltd.)

[0010] Experimental animals: SPF grade C57 mice, male, weighing 20g-22g, provided by the Experimental Animal Center of Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., the animal qualification certificate number is: SCXK (Beijing) 2012-0001.

[0011] 1.2 Experimental methods and results

[0012] 1.2.1 Preparation, grouping and administration of toxicity model mice caused by continuous administration of irinotecan

[0013] 70 male mice, weighing 20-22g, took 60 and divided them into 6 groups, namely normal group, irinotecan group, irinotecan + acyclovir 40mg / kg group, irinotecan + acyclovir 100mg / kg group, irinotecan + acyclov...

experiment example 2

[0022] Experimental example 2 Effect of acyclovir on the survival period of tumor-bearing nude mice administered with irinotecan

[0023] 2.1 Drugs and reagents

[0024] Acyclovir (purity 99.3%, purchased from Shanghai Hanxiang Biotechnology Co., Ltd.)

[0025] Irinotecan hydrochloride (purity 99.5%, purchased from Shanghai Hanxiang Biotechnology Co., Ltd.)

[0026] Experimental animals: BALB / c nude mice SPF grade, male, weighing 20g-22g, provided by the Experimental Animal Center of Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., the animal qualification certificate number is: SCXK (Beijing) 2012-0001.

[0027] 2.2 Experimental methods and results

[0028] 2.2.1 Grouping and administration of tumor-bearing nude mice with continuous administration of irinotecan

[0029] 70 tumor-bearing nude mice, weighing 20-22g, took 60 and divided them into 6 groups, i.e. normal group, irinotecan group, irinotecan + acyclovir 40mg / kg group, irinotecan + acyclovir Wei 100...

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PUM

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Abstract

The invention provides applications of anti-herpes simplex virus drug acyclovir in preventing or / and treating tardive diarrhea caused by one anti-tumor drug and intestinal dysfunctions caused by diarrhea, wherein the anti-tumor drug is irinotecan or active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38) of irinotecan. The drug effect of acyclovir is clear; acyclovir is capable of relieving tardive diarrhea effectively, and protecting intestinal functions.

Description

technical field [0001] The invention belongs to the field of chemical medicine, and in particular relates to the combined use of the anti-herpes simplex virus drug acyclovir and the anti-tumor drug irinotecan, reducing the toxic reaction of irinotecan, increasing the physique of tumor patients, that is, improving the tolerance of tumor patients to irinotecan The dose of irinotecan can be extended to prolong the time of using irinotecan for cancer patients. Background technique [0002] Irinotecan is clinically used for the treatment of advanced colorectal cancer, combined with 5-fluorouracil and leucovorin (LV) to treat patients with advanced colorectal cancer who have not received chemotherapy before; as a single drug, to treat patients who have failed treatment with 5-fluorouracil-containing chemotherapy regimens . Irinotecan Hydrochloride 180mg / m 2 Intravenous infusion for 30-90 minutes, the first day; LV 400mg / m 2 It should be administered immediately after irinotecan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K31/4745A61P1/12A61P35/00
CPCA61K31/522A61K31/4745
Inventor 蒋王林张广华张雪李德芳
Owner BINZHOU MEDICAL COLLEGE
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