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Sustained-release pharmaceutical composition

A technology of drugs and derivatives, applied in the field of sustained-release pharmaceutical compositions, to achieve the effect of sufficient safety

Inactive Publication Date: 2017-12-01
SANTEN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there is no description that the ophthalmic depot preparation can form the same depot regardless of the site of administration or its properties, release the drug slowly, and exert the drug effect over a long period of time.

Method used

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  • Sustained-release pharmaceutical composition
  • Sustained-release pharmaceutical composition
  • Sustained-release pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0161] drug 4g

[0162] Benzyl Benzoate 45g

[0163] PEG400 55g

preparation example 2

[0165] drug 4g

[0166] Benzyl Benzoate 40g

[0167] PEG40060g

preparation example 3

[0169] drug 4g

[0170] Benzyl Benzoate 45g

[0171] Dimethyl sulfoxide 55g

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PUM

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Abstract

The invention relates to an ophthalmic depot formulation containing benzyl benzoate and / or benzyl alcohol and polyethylene glycol and / or dimethylsulfoxide wherein the volume ratio of benzyl benzoate and / or benzyl alcohol and polyethylene glycol and / or dimethylsulfoxide in the ophthalmic depot formulation is 75:25-25:75, and the ophthalmic depot formulation contains a total of 50% (w / w) or more of benzyl benzoate and / or benzyl alcohol and polyethylene glycol and / or dimethylsulfoxide.

Description

technical field [0001] The present invention relates to an ophthalmic depot preparation containing benzyl benzoate and / or benzyl alcohol, polyethylene glycol and / or dimethyl sulfoxide, said ophthalmic depot preparation (depot formulation), the volume ratio of benzyl benzoate and / or benzyl alcohol to polyethylene glycol and / or dimethyl sulfoxide is 75:25 to 25:75, and the ophthalmic depot preparation contains The total content of benzyl benzoate and / or benzyl alcohol, and polyethylene glycol and / or dimethyl sulfoxide is 50% (w / w) or more. [0002] The present invention also relates to an ophthalmic depot preparation containing a drug, and to an ophthalmic depot preparation containing a compound represented by formula (1) or a salt thereof as a drug. [0003] [chemical formula 1] [0004] [0005] [where, [0006] R 1 Indicates hydrogen atom, halogen atom, hydroxyl, C 1-6 Alkyl, C substituted by 1 or more halogen atoms 1-6 Alkyl, C 1-6 Alkoxy or C substituted by 1 or m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/14A61K31/444A61K47/10A61K47/20A61P27/02
CPCA61K47/10A61K47/14A61K47/20A61K9/0051A61K31/444A61K9/0048A61K47/22A61P27/02A61K47/34A61K9/0002
Inventor 冈部高明藤泽丰实山田和人
Owner SANTEN PHARMA CO LTD
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