Artificial biological cardiac and vascular valve on basement membrane component surface layer and preparation method thereof

Abstract

The invention relates to an artificial biological cardiac and vascular valve on a basement membrane component surface layer and a preparation method thereof. The artificial biological cardiac and vascular valve comprises a biovalve material and the basement membrane component surface layer tightly covering the biovalve material. On the basis that the good strength and toughness of a crosslinking biovalve are reserved, rapid endothelialization of the smooth and dense basement membrane component surface layer can be achieved, and calcium salt deposition can be obstructed, so that cytotoxicity and immunogenicity reducing which are caused by calcification and isolation crosslinking of the biovalve are prevented, and the service life of the artificial biological cardiac and vascular valve is prolonged.

Description

technical field [0001] The invention belongs to the field of artificial biological heart / vascular valve and its preparation, in particular to an artificial biological heart / vascular valve with basement membrane component surface layer and its preparation method. Background technique [0002] Artificial heart valve replacement is the main treatment for valve disease. Mechanical valves are durable, but anticoagulant drugs need to be taken for life, the incidence of thromboembolism is high, and bleeding complications may occur. Biological valves have similar hydrodynamic properties to human heart valves and are more biocompatible than mechanical valves, and patients only need short-term or no anticoagulant drugs. However, easy calcification, poor durability, and certain immunogenicity are the main factors limiting the application of biological valves. Phosphate groups contained in cell debris or cell membranes, and the exposure of carboxyl groups, aldehyde groups, amino group...

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Problems solved by technology

CN101690829A uses nordihydroguaiaretic acid to cross-link the porcine aortic valve, and CN10135870A uses epichlorohydrin to cross-link the decellularized valve. At present, the biocompatibility, immunogenicity in animal experiments, and cytotoxicity are not significantly better than pentadiene Aldehydes, and lack of in vivo data and reports of long-term implantation outcomes

Natural scaffold materials are acellular matrix materials, collagen scaffolds, polysaccharide scaffolds, etc., which have the advantages of high immunogenicity and good biological safety, but have the disadvantages of rapid degradation in vivo and uncontrollable degradation time.

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