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Polypeptide polymer nanomaterial and preparing method and application thereof

A technology of nanomaterials and peptide polymers, applied in drug combinations, pharmaceutical formulations, peptide/protein components, etc., can solve problems such as poor therapeutic effects, achieve wide application prospects, improve efficiency, and achieve good biocompatibility effects

Active Publication Date: 2017-12-01
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Judging from the current research status of Alzheimer's disease, although some achievements have been made, the treatment effect is not good.

Method used

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  • Polypeptide polymer nanomaterial and preparing method and application thereof
  • Polypeptide polymer nanomaterial and preparing method and application thereof
  • Polypeptide polymer nanomaterial and preparing method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0065] In this embodiment, the structure of the polypeptide polymer nanomaterial is as follows:

[0066]

[0067] That is, in the formula I provided by the present invention, R 1 The donor is CFFVLKG, R 2 The donor is CTNVFNATFHIWHSGQFGT, R 3 The donor is carboxy-terminated polyethylene glycol with a molecular weight of 368 g mol -1 , m / n=1 / 1 is M 1-1 .

[0068] The synthetic method of described polypeptide polymer is as follows:

[0069] Using resin as a carrier, carboxyl-terminated polyethylene glycol and amino acid as raw materials, according to the connection sequence of the polypeptide, using solid-phase synthesis method, the carboxyl-terminated polyethylene glycol and amino acid are coupled in sequence, and finally trifluoroacetic acid. The product is cleaved from the carrier and purified to obtain the polypeptide compound HS-R 1 -R 3 and R 2 -SH;

[0070] HS-R 1 -R 3 and R 2 -SH performs Michale addition reaction with excess acrylylated chitosan according...

Embodiment 2

[0072] The only difference from Example 1 is that the HS-R 1 -R 3 and R 2 -SH performs Michale addition reaction with excess acrylylated chitosan according to a ratio of 1 / 3 to obtain a polypeptide polymer. Since m / n=1 / 3, it is denoted as M 1-3 .

Embodiment 3

[0074] The only difference from Example 1 is that the HS-R 1 -R 3 and R 2 -SH performs Michale addition reaction with excess acrylylated chitosan according to the ratio of 3 / 1 to obtain a polypeptide polymer. Since m / n=3 / 1, it is denoted as M 3-1 .

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Abstract

The invention provides a polypeptide polymer nanomaterial and a preparing method and application thereof. The polypeptide polymer nanomaterial comprises chitosan, a polypeptide sequence for recognizing beta-amyloid protein and a polypeptide sequence for activating autophagy, and the polypeptide sequences are connected to the chitosan. A polypeptide polymer prepared through solid-phase synthesis and Michael addition has good biological compatibility and anti-A[beta] neurotoxicity, polypeptide polymer nanospheres obtained from the polypeptide polymer can be co-assembled with A[beta] so as to effectively prevent aggregation of A[beta] and reduce the neurotoxicity of A[beta], meanwhile, a co-assembly can activate autophagy after entering cells, A[beta] can be degraded through autophagy, so that Alzheimer's disease can be treated in a synergic mode, the Alzheimer's disease treatment efficiency of the polypeptide nanomaterial is improved greatly, and application prospects are broad.

Description

technical field [0001] The invention belongs to the field of polymer materials, and relates to a polypeptide polymer nanomaterial and its preparation method and application, in particular to a multifunctional polypeptide polymer nanomaterial, its preparation method and its application in Alzheimer's disease. Background technique [0002] Alzheimer's disease is considered to be the most prevalent neurodegenerative disease. In 2015, nearly 50 million people worldwide suffered from dementia. So far, there is no effective treatment for Alzheimer's disease, and research on Alzheimer's disease is of great significance. It is well known that an important pathological hallmark of Alzheimer's disease is the extracellular deposition of Aβ (β-amyloid protein) and intracellular neurofibrillary tangles. In the past few decades, one of the main strategies for Alzheimer's disease research has been to design inhibitors against Aβ, with the purpose of preventing its extracellular deposition...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/61A61K47/69A61K38/10A61K9/14A61P25/28C08B37/08A61K38/08
CPCA61K9/146A61K38/08A61K38/10C08B37/003A61K2300/00
Inventor 王浩罗强林耀新王磊
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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