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Vaccine for preventing sheep from brucellosis

A technology of Brucella sheep and Brucella, which is applied in the field of vaccines for the prevention of Brucellosis sheep, can solve problems affecting disease diagnosis, achieve simple and safe vaccination methods, reduce biosafety risks, and achieve the effects of small doses

Inactive Publication Date: 2017-12-01
JINYUBAOLING BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to provide a vaccine for preventing brucellosis in order to solve the technical problem in the prior art that the vaccine for preventing brucellosis affects the disease diagnosis at the later stage of immunity

Method used

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  • Vaccine for preventing sheep from brucellosis
  • Vaccine for preventing sheep from brucellosis
  • Vaccine for preventing sheep from brucellosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] vaccine use

[0050] 1. Pour the diluent into the vaccine bottle and mix well.

[0051] 2. Use an eye dropper to drop the vaccine into the eye socket of the animal to be immunized, and the immunization is successful if the vaccine liquid does not flow out of the eye socket of the animal.

[0052] Safety Test of Brucellosis Live Vaccine (Rev.1 Strain)

[0053] 1. 25 healthy susceptible sheep and goats aged 3 to 6 months without brucellosis infection were randomly divided into 5 groups, with 5 sheep in each group.

[0054] 2. Select 3 batches of brucellosis live vaccine (Rev.1 strain), dissolve and dilute with diluent, and instill 10 doses in the eyes of the first group to the third group, that is, 1.0×10 10 CFU.

[0055] 3. Select a batch of brucellosis live vaccine (S2 strain), dissolve and dilute to 1.0×10 with normal saline 11 CFU / ml, the fourth group was orally immunized with 1ml, that is, 10 servings (the number of viable bacteria in each serving was based on the ...

Embodiment 2

[0065] Immunization test of live brucellosis vaccine (Rev.1 strain) with different inoculation methods

[0066] 80 healthy susceptible sheep aged 3 to 6 months without brucellosis infection were randomly divided into experimental groups, and a batch of brucellosis live vaccine (Rev.1 strain) was selected, dissolved and diluted with a special diluent, and eye-dropped , oral and subcutaneous injection of 20 healthy susceptible sheep aged 3 to 6 months, 1 head per head, that is, 1.0×10 9 CFU.

[0067] Blood was collected before immunization, and blood was collected 14 days, 28 days, 49 days, 60 days, 90 days, 120 days, and 150 days after immunization. Antibody responses were detected by tiger red plate agglutination test (RBPT). Table 3 shows the test results of antibody level detection (positive rate) after immunization with different vaccination methods.

[0068] table 3

[0069]

[0070]

[0071] Table 3 test results show that:

[0072] 1. Among the three immunizati...

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Abstract

The invention discloses a vaccine for preventing sheep from brucellosis. The vaccine is an eye drop vaccination and comprises a brucellosis live vaccine and a vaccine diluent. By application of the vaccine, which is the eye drop vaccination and comprises the brucellosis live vaccine and the vaccine diluent, through eye drop vaccination, the dosage is small, the vaccination mode is simple and safe, the vaccine liquid cannot be spread into the environment a lot, and accordingly, the biological safety risk is reduced.

Description

technical field [0001] The invention relates to the field of veterinary biological products, in particular to a vaccine for preventing brucellosis sheep. Background technique [0002] Brucellosis ("brucellosis" for short) is a zoonotic disease characterized by abortion and fever caused by Brucella, which seriously threatens the life and health of humans and various animals. The World Organization for Animal Health (OIE) classifies it as a Class B disease, and it is widely distributed all over the world. Symptoms such as miscarriage, stillbirth, infertility, mastitis and orchitis appear after animal infection, resulting in reduced reproductive capacity and production performance, and huge economic losses. People infected with Brucella can cause fever, miscarriage, infertility, chronic arthritis, and nerve damage. Brucellosis has the characteristics of wide range of hosts, strong infectivity, and difficulty in curing after infection, which poses a serious threat to animal hu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/10A61K9/19A61K47/20A61P31/04
CPCA61K39/098A61K47/20A61K9/19A61K2039/54A61K2039/552
Inventor 魏学峰赵丹彤郝雪斌刘国英吴梅花侯振宇杨春王英闫聪鲁燕范秀丽吴咏梅韩志玲陈九连李雪峰
Owner JINYUBAOLING BIO PHARMA CO LTD
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