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Biomimetic non-uniformity structure bioglass scaffold and preparing method thereof

A bioglass, uniform technology, applied in the direction of tissue regeneration, medical science, prosthesis, etc., can solve the problems of affecting the mechanical properties of materials, unfavorable cell proliferation and vascular ingrowth, unfavorable cell adhesion and migration, etc., and achieves a simple and practical preparation method, The effect of good biological activity and easy control of process parameters

Inactive Publication Date: 2017-11-24
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the introduction of 3D printing has solved the problem of connecting three-dimensional structures, but most of the printed scaffold materials have uniform pores, which are far from the structure of human bones with dense outer and inner sparse structures; in addition, excessively large pore diameters will affect the mechanical properties of materials and will not It is conducive to the adhesion and migration of cells, while too small a pore size is not conducive to cell proliferation and blood vessel growth

Method used

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  • Biomimetic non-uniformity structure bioglass scaffold and preparing method thereof
  • Biomimetic non-uniformity structure bioglass scaffold and preparing method thereof
  • Biomimetic non-uniformity structure bioglass scaffold and preparing method thereof

Examples

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Embodiment 1

[0040] The preparation of the biomimetic heterogeneous structure bioactive glass scaffold uses modeling software and 3D printing technology to shape the material, including the following steps and processes:

[0041] (1) Construction of bionic heterogeneous structure

[0042] (1) Use Solidworks software to construct a three-dimensional model of a concentric cylinder with an outer diameter of 16mm, an inner diameter of 5mm, and a height of 4mm;

[0043] (2) Import the model into 3D-bioplotter software and Visual machine software for layering and internal structure design. The layer spacing is set to 0.32mm, the outer circle fiber spacing is set to 0.8mm, the inner circle fiber spacing is set to 1mm, and the fiber direction is set to 0° for the x-axis and 90° for the y-axis.

[0044] (2) Preparation of bioglass scaffolds with heterogeneous structure

[0045] (1) Add 30 parts by weight of glycerin and 30 parts by weight of ethanol to 70 parts by weight of deionized water, stir ...

Embodiment 2

[0053] The preparation of the biomimetic heterogeneous structure bioactive glass scaffold uses modeling software and 3D printing technology to shape the material, including the following steps and processes:

[0054] (1) Construction of bionic heterogeneous structure

[0055] (1) Use Solidworks software to build a three-dimensional model of a concentric cylinder with an outer diameter of 16mm, an inner diameter of 11mm, and a height of 4mm;

[0056] (2) Import the model into 3D-bioplotter software and Visual machine software for layering and internal structure design. The layer spacing is set to 0.32mm, the outer circle fiber spacing is set to 0.8mm, the inner circle fiber spacing is set to 1mm, and the fiber direction is set to 0° for the x-axis and 90° for the y-axis.

[0057] (2) Preparation of bioglass scaffolds with heterogeneous structure

[0058] (1) Add 30 parts by weight of glycerin and 30 parts by weight of ethanol to 70 parts by weight of deionized water, stir for...

Embodiment 3

[0065] The preparation of the biomimetic heterogeneous structure bioactive glass scaffold uses modeling software and 3D printing technology to shape the material, including the following steps and processes:

[0066] (1) Construction of bionic heterogeneous structure

[0067] (1) Use Solidworks software to build a three-dimensional model of a concentric cylinder with an outer diameter of 16mm, an inner diameter of 8mm, and a height of 4mm;

[0068] (2) Import the model into 3D-bioplotter software and Visual machine software for layering and internal structure design. The layer spacing is set to 0.32mm, the outer circle fiber spacing is set to 0.8mm, the inner circle fiber spacing is set to 1mm, and the fiber direction is set to 0° for the x-axis and 90° for the y-axis.

[0069] (2) Preparation of bioglass scaffolds with heterogeneous structure

[0070] (1) Add 30 parts by weight of glycerin and 30 parts by weight of ethanol to 70 parts by weight of deionized water, stir for ...

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Abstract

The invention discloses a biomimetic non-uniformity structure bioglass scaffold and a preparing method thereof. The preparing method comprises the following steps that (1) a biomimetic non-uniformity structure is built; and (2) the biomimetic non-uniformity structure bioglass scaffold is prepared. The biomimetic non-uniformity structure bioglass scaffold has a three-dimensional communicating network skeleton structure, and has good mechanical strength, biocompatibility and biological activity, and meanwhile, biodegradation is achieved; and the compressive strength reaches 4.55-8.01 Mpa, and the poriness reaches 65-85%. The biomimetic non-uniformity structure bioglass scaffold meets demand that supporting is provided for tissue defect parts, cell proliferation and cell migration are achieved advantageously through a three-dimensional communicating gradient pore structure, and ingrowth of blood vessels, nutrient delivery and waste discharging are achieved advantageously. The preparing method is simple and practical, technological parameters are easy to control, and scale production can be achieved.

Description

technical field [0001] The invention relates to the technical field of preparation of biomedical artificial bone repair materials, in particular to a bionic heterogeneous structure bioglass support and a preparation method thereof. Background technique [0002] Bone defect repair materials are one of the biomedical materials with the greatest clinical demand. The number of patients with bone tissue defects caused by diseases such as population aging and industrial, traffic, and sports accidents, such as traumatic fractures, bone tissue necrosis, and bone tumors, reaches millions every year, and there is an increasing trend. The market for bone repair materials is huge. Finding better bone tissue regeneration repair materials to restore health for patients is the frontier and hotspot of biomedical material research. [0003] Due to the bioactivity, biocompatibility, and biodegradability of bioglass, it has promising application prospects in tissue engineering scaffold materi...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/54A61L27/56A61L27/50B33Y10/00B33Y70/00
CPCA61L27/10A61L27/50A61L27/54A61L27/56A61L2430/02B33Y10/00B33Y70/00
Inventor 张颖杭飞陈晓峰代坤
Owner SOUTH CHINA UNIV OF TECH
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