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Scar repair agent and preparation method thereof

A repairing agent and scar technology, applied in the field of scar repairing agent and its preparation, can solve the problem of not meeting the needs of the market, and achieve the effects of reducing scar hyperplasia index, improving stability and inhibiting proliferation

Active Publication Date: 2017-11-24
广东省华桑丽皙生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although various products developed for scar removal have emerged in an endless stream in recent years, there are still relatively few products with significant curative effect, high safety, convenient use and industrial production, which cannot meet the needs of the market.

Method used

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  • Scar repair agent and preparation method thereof
  • Scar repair agent and preparation method thereof
  • Scar repair agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation of embodiment 1 cytokine liposome

[0034]

[0035]Preparation of group A liposomes:

[0036] (1) Weigh hydrogenated lecithin, sodium cholesterin and cholesterol, add absolute ethanol to make a solution A with a concentration of 4 mg / mL;

[0037] (2) Take hesperidin and add dimethylformamide to make a solution B with a concentration of 0.2 mg / mL;

[0038] (3) Add rhIL-12 to a phosphate buffer solution with a pH of 7.4 to prepare a solution C with a concentration of 0.05 mg / mL;

[0039] (4) Mix solution A and solution B, rotatively evaporate at 28°C, 0.1MPa, remove ethanol and dimethylformamide, let it stand for 10 minutes, add solution C, shake in a water bath at 35°C for about hydration reaction After 1 hour, the liposome suspension was obtained, and then the particle size of the liposome suspension was adjusted to 150nm using a syringe filter.

[0040] The preparation of group B-E liposomes refers to the above-mentioned group A.

[0041] The pre...

Embodiment 2

[0044] The preparation of embodiment 2 scar repair agent:

[0045] (1) Take oat polypeptide, papaya extract, snail secretion, L-sodium pyrrolidone carboxylate, and diguanosine tetraphosphate, dissolve them in water, and set aside;

[0046] (2) Mix ethylhexylglycerin and olive oil, add the aqueous solution obtained in step (1), alkyl glycosides, and cytokine liposomes prepared in Example 1B in sequence, stir and emulsify to obtain the product.

[0047] For the preparation of the scar repair agents of Examples 3 and 4 and Comparative Examples 1-5, refer to the above-mentioned method.

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Abstract

The invention relates to a scar repair agent. The scar repair agent is prepared from components in parts by weight as follows: 1-2 parts of oat polypeptides, 0.5-6 parts of a fructus chaenomelis extract, 0.05-1 part of a snail secretion fluid, 2-4 parts of L-sodium pyrrolidonecarboxylate, 0.1-0.5 parts of diguanosine tetraphosphate, 1-2 parts of cytokine liposome, 3-6 parts of ethylhexylglycerin, 10-20 parts of olive oil, 2-4 parts of alkyl glycoside and 30-50 parts of water. The scar repair agent contains coordinated ingredients, has a remarkable scar repairing effect, has no irritation to skin, is high in safety, has the efficacy of moisturizing and tendering skin and resisting oxidation and ageing, can effectively fade scar stains and inhibit hyperpigmentation to recover skin to the natural state, evens skin color and can smooth lines and promote skin firmness.

Description

technical field [0001] The invention relates to the technical field of scar repair, in particular to a scar repair agent and a preparation method thereof. Background technique [0002] Scar is formed after the skin tissue of the human body is subjected to various external traumas, and the skin fibrous connective tissue hyperplasia fills, connects, supports, and protects the surrounding normal tissues at the wound healing site. At present, the mechanism of scar formation is not yet fully understood. It is generally believed that the massive proliferation and apoptosis of fibroblasts in wound repair, the imbalance of collagen synthesis and degradation in the extracellular matrix, and the abnormal expression of related cytokines constitute scar formation. biological basis. [0003] Scars not only destroy the beauty of the body surface, but may also affect the function of related tissues or organs, and even cause deformities in more serious cases. With the improvement of the q...

Claims

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Application Information

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IPC IPC(8): A61K38/20A61K38/01A61P17/02A61K36/732A61K35/618A61K31/198A61K31/708
CPCA61K31/198A61K31/708A61K35/618A61K36/732A61K38/011A61K38/208A61K2300/00
Inventor 陈松彬倪彦艳陈健欢刘杰森李宇腾
Owner 广东省华桑丽皙生物技术有限公司
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