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A kind of autologous arterial blood purified liquid injection preparation and its preparation and application

An injection preparation, arterial blood technology, applied in the medical field, can solve the problems of inability to achieve centrifugation to remove red blood cells by stratification, platelet-rich plasma fiber side effects, and change the physical and chemical properties of blood, etc., to increase the application effect, reduce the psychological defense line, and improve the skin. Effect

Active Publication Date: 2020-09-08
CHENGDU QINGKE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no one in this field has started research on liquid platelet-rich fibrin, because: one: as far as the current research is concerned, chemical substances such as calcium chloride and thrombin must be added in order to obtain a liquid state. After adding chemical substances, there will be certain toxic and side effects, and this extraction method will usually change the physical and chemical properties of the blood, resulting in the reinjection of platelet-rich plasma fibers into the human body with certain side effects, which cannot be used in vivo or is severely affected. big limit
Second: Since the isolated blood is very easy to coagulate without adding any additives, it usually coagulates before the centrifugation starts, even if it is not completely coagulated, it will coagulate during the centrifugation process, and complete centrifugation cannot be achieved The operation of removing red blood cells in the first layer, and even if they are separated, it will take a long time in the later injection process, and coagulation will also be carried out
Therefore, in theory, it is impossible to obtain a pure liquid autologous blood PRF injection preparation without adding additives, and complete the injection with a syringe
Therefore, no researcher considers the research direction from the direction of this dead end

Method used

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  • A kind of autologous arterial blood purified liquid injection preparation and its preparation and application
  • A kind of autologous arterial blood purified liquid injection preparation and its preparation and application
  • A kind of autologous arterial blood purified liquid injection preparation and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Such as Figure 1~4 As shown, a blood processing device includes a centrifugal device 5 and a refrigeration device capable of cooling the centrifugal device 5 . The refrigerating device of the centrifugal device 5 includes a refrigerated box body 1, which includes a housing 2 containing a refrigeration system, a refrigerating chamber 3 surrounded by the housing 2, and a heat-insulating insulation box arranged at the top opening of the housing 2. The top cover 4 ; the centrifugal device 5 is detachably arranged in the refrigerating chamber 3 , such as being placed in the refrigerating chamber 3 .

[0050] The centrifuge device 5 is connected with an oscillator 6 that can provide an oscillation frequency for the centrifuge device 5, so that when the centrifuge tube is centrifuged, the oscillator 6 will give an additional oscillation frequency, which can improve the centrifugation effect at low temperature. The oscillation frequency of the oscillator 6 ranges from 1HZ to ...

Embodiment 2

[0066] A method for preparing a liquid injection preparation, comprising a blood treatment device and a blood treatment method using the device. The structure of the blood treatment device is as described in Example 1.

[0067] The blood processing method comprises the following steps:

[0068] S1: Set the temperature of the centrifuge device to 4°C, the rotation speed to 1500g and the centrifugation time to 5min;

[0069] S2: Take arterial blood and put it in a centrifuge tube. Before the arterial blood leaves the human body and is put into the blood processing device, the centrifuge tube containing the arterial blood needs to be shaken at a frequency of 30 times / minute;

[0070] S3: Place the centrifuge tube in a centrifuge device. The specific centrifugation process is as follows: firstly, centrifuge at 1500g at 4°C for 5min; then centrifuge at 1000g at 7°C for 3min.

[0071] S4: After centrifugation, the red blood cell layer at the bottom was removed with a syringe to obt...

Embodiment 3

[0074] A method for preparing a liquid injection preparation, comprising a blood treatment device and a blood treatment method using the device. The structure of the blood treatment device is as described in Example 1.

[0075] The blood processing method comprises the following steps:

[0076] S1: Set the temperature of the centrifugal device to 5°C, the rotational speed to 2000g, and the centrifugation time to 3 minutes; and set the oscillation frequency of the oscillator to 3;

[0077] S2: Take 20ml of arterial blood and put it in two 15ml centrifuge tubes. Before the arterial blood leaves the human body and is put into the blood processing device, the centrifuge tube containing the arterial blood needs to be shaken at a frequency of 50 times / minute;

[0078] S3: Place the centrifuge tube in the centrifuge device, and immediately turn on the centrifuge device. The specific centrifugation process is as follows: first, centrifuge at 5°C for 3 minutes at a speed of 2000g, whic...

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Abstract

The invention relates to an autologous-arterial-blood pure liquid-state injection preparation and a preparing method and application thereof. The preparing method uses a blood processing device and includes a blood processing method. The blood processing method includes the steps of S1, setting the parameters of a centrifuging device; S2, taking arterial blood; S3, placing a centrifuge tube in the centrifuging device, and immediately centrifuging under 500-2000g for 3-7 minutes; S4, taking supernate after the centrifuging to obtain the liquid-state injection preparation. The liquid-state injection preparation has the advantages that the liquid-state injection preparation can be used for treating various diseases such as alopecia and knee joint, bone, periosteum and reproductive organ diseases; the liquid-state injection preparation can treat the diseases or achieve a healthcare effect through in-vivo injection, is evident in curative effect and has extremely important significance and value, and the application range of the liquid-state injection preparation is expanded greatly.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to an autologous arterial blood purified liquid injection preparation and its preparation and application. Background technique [0002] PRP (Platelet Rich Plasma) is platelet-rich plasma or blood rich in growth factors. PRP technology refers to using one's own blood, adding additives, and then extracting plasma rich in high-concentration platelets and various self-growth factors. These factors play an extremely important role in promoting wound healing, cell proliferation and differentiation, and tissue formation. In the past, PRP was mainly used in surgery, heart surgery and burns to cure diseases such as large area burns, chronic ulcers and limb ulcers that could not be cured before. PRP technology was first applied and studied in oral surgery by Dr.Robert Marx in 1998, which is the earliest recorded medical literature. PRP belongs to a generation of products. [0003] PRF i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/14A61P17/14A61P19/02A61P19/08A61P1/02A61P19/04A61P15/00
CPCA61K9/0019A61K35/14
Inventor 翟跃中
Owner CHENGDU QINGKE BIOTECH
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