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Preparation method of hollow vesicular manganous silicate nanoparticles with stable arginine, product and application thereof

An arginine, nanoparticle technology, applied in nanotechnology for sensing, preparations for in vivo experiments, nanotechnology for materials and surface science, etc., can solve the complex synthesis process of contrast agents and cannot be batched. Production and other issues, to achieve the effect of enhancing T1 imaging effect, good biological safety, and good possibility of clinical transformation

Active Publication Date: 2017-11-17
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the synthesis process of the contrast agent obtained by this method is complicated, it cannot be produced in batches, and different ligands need to be selected on the surface of different nanoparticles. Therefore, there is still a long way to go for clinical promotion of inorganic nanoparticles obtained under oil phase conditions. Walk

Method used

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  • Preparation method of hollow vesicular manganous silicate nanoparticles with stable arginine, product and application thereof
  • Preparation method of hollow vesicular manganous silicate nanoparticles with stable arginine, product and application thereof
  • Preparation method of hollow vesicular manganous silicate nanoparticles with stable arginine, product and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0049](1) Weigh 50mg of arginine, add it to a round bottom flask filled with 40ml of deionized water, stir and dissolve it under the condition of a magnetic stirrer at 500-600r / min, then add 3ml of cyclohexane, and heat to 50°C, Then add tetraethyl orthosilicate (TEOS) 3ml, react for 24 hours, after the reaction is finished, use a separatory funnel to stand and separate, remove the upper layer of cyclohexane, and obtain arginine-stabilized silica nanoparticles.

[0050] The as-prepared arginine-stabilized silica nanoparticles were characterized by TEM, and the results were as follows: figure 1 As shown, the particle size of silica nanoparticles is about 20 nm.

[0051] (2) Weigh 25 mg of potassium permanganate solid, 4 ml of deionized water, 1.5 ml of ethanol, and 0.5 ml of silica nanoparticles (20 mg / ml), mix them and put them into an autoclave, and react at 190 ° C for 24 hours, and cooled to room temperature after the reaction. Then it was washed with deionized water and ...

Embodiment 2

[0056] (1) Weigh 50 mg of arginine, add it to a round bottom flask containing 40 ml of deionized water, stir and dissolve it under the condition of a magnetic stirrer at 500-600 r / min, then add 4 ml of cyclohexane, and heat to 60 °C, Then add tetraethyl orthosilicate (TEOS) 3ml, react for 24 hours, after the reaction is finished, use a separatory funnel to stand and separate, remove the upper layer of cyclohexane, and obtain arginine-stabilized silica nanoparticles.

[0057] (2) Weigh 25 mg of potassium permanganate solid, 4 ml of deionized water, 1.5 ml of ethanol, and 0.5 ml of silica nanoparticles (20 mg / ml), mix them and put them into an autoclave, and react at 200 ° C for 24 hours, and cooled to room temperature after the reaction. Then it was washed with deionized water and centrifuged three times, and finally the obtained arginine-stabilized hollow vesicular manganese silicate nanoparticles were dispersed in 10 ml of water.

Embodiment 3

[0059] (1) Weigh 50 mg of arginine, add it to a round bottom flask containing 40 ml of deionized water, stir and dissolve it under the condition of a magnetic stirrer at 500-600 r / min, then add 3 ml of cyclohexane, and heat to 60 °C, Then add tetraethyl orthosilicate (TEOS) 3ml, react for 30 hours, after the reaction is finished, use a separatory funnel to stand and separate, remove the upper layer of cyclohexane, and obtain arginine-stabilized silica nanoparticles.

[0060] (2) Weigh 25mg of potassium permanganate solid, 4ml of deionized water, 1.5ml of ethanol, 0.5ml of silica nanoparticles (20mg / ml), mix them and put them into an autoclave, and react at 180°C for 30 hours, and cooled to room temperature after the reaction. Then it was washed with deionized water and centrifuged three times, and finally the obtained arginine-stabilized hollow vesicular manganese silicate nanoparticles were dispersed in 10 ml of water.

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Abstract

The invention relates to a preparation method of hollow vesicular manganous silicate nanoparticles with stable arginine, a product and an application thereof. The preparation method comprises the following steps: 1) dissolving arginine in water, adding cyclohexane and mixing the materials, heating a mixture, then adding ethyl orthosilicate for a reaction, after the reaction is completed, removing cyclohexane to obtain the silica nanoparticles with stable arginine; and 2) mixing the silica nanoparticles, potassium permanganate, ethanol and water and performing a hydro-thermal reaction, and separating the mixture to obtain the hollow vesicular manganous silicate nanoparticles. The prepared hollow vesicular manganous silicate nanoparticles with stable arginine can generate good T1 imaging effect during a magnetic resonance imaging process.

Description

technical field [0001] The invention belongs to the field of preparation of nuclear magnetic resonance imaging contrast agents, and in particular relates to a preparation method, product and application of arginine-stabilized hollow vesicular manganese silicate nanoparticles. Background technique [0002] In recent years, magnetic resonance imaging (MRI) has become a very important diagnostic tool in clinical medicine with its powerful imaging capabilities. It can penetrate deep into the tissues of the human body and detect disease damage and treatment effects in real time and dynamically. At the same time, the entire detection and diagnosis process is non-invasive and will not cause physical damage and pain to patients. For the abnormal conditions and tissue damage of the patient's body, MRI technology can provide accurate and detailed diagnosis basis for doctors. Therefore, MRI technology is increasingly accepted by patients and valued by doctors in clinical diagnosis. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18B82Y5/00B82Y15/00C01B33/20B82Y30/00B82Y40/00
CPCA61K49/1824B82Y5/00B82Y15/00B82Y30/00B82Y40/00C01B33/20C01P2002/72C01P2002/85C01P2004/04C01P2004/34C01P2004/64C01P2006/32
Inventor 凌代舜李方园王帅飞
Owner ZHEJIANG UNIV
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