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A kind of polymerizable ZnS nanoparticle, preparation method and method for preparing high refraction ophthalmic refractive correction material

A nanoparticle, high-refraction technology, applied in the field of medical biomaterials and tissue engineering, can solve the problems of reducing the optical properties of materials, difficult to ensure the mechanical properties of contact lenses, and undisclosed mechanical properties of materials, etc., to achieve simple synthesis and good mechanical properties , good anti-agglomeration effect

Active Publication Date: 2019-08-13
山东济清科技服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the preparation process of existing contact lens hydrogel materials, DMA and NVP are used as functional monomers, and it is difficult to guarantee the mechanical performance requirements for use as contact lenses by using it as the main skeleton structure of the hydrogel. Document CN 201511003965.7 A also does not disclose the data related to the mechanical properties of the material. In addition, because the ZnS nanoparticles are physically embedded in the pDMA-NVP gel skeleton, the ZnS particles may be agglomerated and cause phase separation during long-term placement or use of the lens. , thereby reducing the optical properties of the material

Method used

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  • A kind of polymerizable ZnS nanoparticle, preparation method and method for preparing high refraction ophthalmic refractive correction material
  • A kind of polymerizable ZnS nanoparticle, preparation method and method for preparing high refraction ophthalmic refractive correction material
  • A kind of polymerizable ZnS nanoparticle, preparation method and method for preparing high refraction ophthalmic refractive correction material

Examples

Experimental program
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Embodiment 1

[0070] A polymerizable ZnS nanoparticle, the polymerizable ZnS nanoparticle is grafted on the surface of the ZnS nanoparticle with a structure shown in formula III:

[0071]

[0072] The preparation method of the above-mentioned polymerizable ZnS nanoparticles comprises the following steps:

[0073] (1) Weigh zinc acetate dihydrate (11g, 0.05mol), mercaptoethanol (5.8g, 0.074mol), thiourea (2.75g, 0.036mol), pour it into a 200mL three-necked flask, add 150ml N,N-di Methylformamide (DMF) was dissolved, stirred magnetically, and refluxed at 160°C for 10 h under nitrogen protection. The reaction solution was concentrated to 40 ml by a rotary evaporator under reduced pressure, and then added dropwise to excess ethanol to precipitate. The precipitate was washed with methanol, and then Vacuum drying at 30°C overnight to obtain mercaptoethanol-modified ZnS nanoparticles.

[0074] (2) Weigh 1 g of mercaptoethanol-modified ZnS nanoparticles, dissolve it in 25 mL of DMF, and add 0.0...

Embodiment 2

[0077] A preparation method of polymerizable ZnS nanoparticles, the steps are as described in Example 1, the difference is: the addition of 2-isocyanoethyl methacrylate is 0.1g, and the other steps are consistent with Example 1 , the resulting polymerizable ZnS nanoparticles, labeled as ZnS 0.10 , where the subscript 0.1 represents the mass ratio of 2-isocyanoethyl methacrylate to mercaptoethanol-modified ZnS nanoparticles.

[0078] The particle size of the polymerizable ZnS nanoparticles prepared in this example is about 4 nm.

Embodiment 3

[0080] A preparation method of polymerizable ZnS nanoparticles, the steps are as described in Example 1, the difference is: the addition of 2-isocyanoethyl methacrylate is 0.15g, and the other steps are consistent with Example 1 , the resulting polymerizable ZnS nanoparticles, labeled as ZnS 0.15, where the subscript 0.15 represents the mass ratio of 2-isocyanoethyl methacrylate to mercaptoethanol-modified ZnS nanoparticles.

[0081] The particle size of the polymerizable ZnS nanoparticles prepared in this example is about 4 nm.

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Abstract

The invention relates to a polymerizable ZnS nanoparticle, a preparation method and a method for preparing high-refractive ophthalmic refractive correction materials. The present invention first uses zinc salt, mercaptoalcohol and thiourea as main raw materials to prepare mercaptoalcohol-modified ZnS nanoparticles; then, the mercaptoalcohol-modified ZnS nanoparticles react with 2-isocyanomethacrylate to obtain polymerizable ZnS nanoparticles. grain. The present invention can achieve controllable grafting of the number of polymerizable groups on the surface of ZnS nanoparticles, thereby controlling the cross-linking degree and modulus of the material after the polymerizable ZnS nanoparticles are introduced into the polymer hydrogel body; and the surface of the ZnS nanoparticles of the present invention can be controlled. The grafting reaction of the polymerizable group is completed in one step, and the synthesis is simple. The refractive correction material prepared by using the polymerizable ZnS nanoparticles of the present invention has the properties expected of a refractive correction material such as high water content, high refractive index, and excellent mechanical properties.

Description

technical field [0001] The invention relates to a polymerizable ZnS nanoparticle, a preparation method and a method for preparing a high-refraction ophthalmic refractive correction material, and belongs to the fields of medical biological materials and tissue engineering. Background technique [0002] As the world's population ages and the time spent using computers increases, the chances of suffering from eye diseases such as myopia and cataracts continue to increase. According to reports, 43% of the population aged 4 to 74 in the United States suffer from mild myopia (less than -5.00D), 3.2% of the population has myopia between 500-1000 degrees (-5.01to-10.00D), and another 0.2% of the population The degree of myopia is greater than 1000 degrees; while the number of myopia patients in my country has reached 400 million, and the incidence rate in universities is even as high as 80%. Cataract, especially senile cataract, is one of the most common eye diseases and the first c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F292/00C08F220/28C08F220/14C08F220/32G02C7/04
CPCG02C7/049C08F292/00C08F220/325C08F220/281
Inventor 徐金库
Owner 山东济清科技服务有限公司
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