Dendrobium eye drops for treating conjunctivitis and keratitis caused by bacterial infection

A technology for bacterial infection and conjunctivitis, used in antibacterial drugs, sensory diseases, topical antibacterial agents, etc., can solve the problems of inability to achieve effective ingredient extraction efficiency, poor curative effect, unreasonable raw material compatibility, etc., and achieve significant therapeutic effects, The effect of quick effect and reasonable production process

Active Publication Date: 2020-05-12
海南诗博丽生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The traditional Chinese medicine eye drops that are currently used for the treatment of eye diseases has gained widespread attention due to the advantages of low raw material prices and low side effects, but the following problems still exist in the prior art products: 1. The compatibility of raw materials is unreasonable and the curative effect is not good; 2. The processing technology is relatively simple and cannot maximize the extraction efficiency of active ingredients

Method used

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  • Dendrobium eye drops for treating conjunctivitis and keratitis caused by bacterial infection
  • Dendrobium eye drops for treating conjunctivitis and keratitis caused by bacterial infection
  • Dendrobium eye drops for treating conjunctivitis and keratitis caused by bacterial infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A dendrobium eye drop is composed of the following components in mass percentage: 45% of Dendrobium officinale, 18% of Danpi, 8% of Shichangpu, 6% of Atractylodes macrocephala, 6% of Fructus Cnidii, 3% of Magnolia magnolia, 5% of chitosan, Vitamin B 12 Powder 3%, Vitamin B 1 3%, saline 3%.

[0027] The preparation method is as follows:

[0028] (1). Weigh the Dendrobium officinale of prescription quantity, mix Dendrobium officinale and the hydrochloric acid solution that concentration is 0.5mol / L by mass ratio 1:2, soak for 2 hours; Then wash with deionized water, drain; Then put Freeze in a freezer at -35°C for 50 hours, take it out, mix it with the prescribed amount of paeonol, add 3 times the amount of absolute ethanol to soak for 3 hours; then wash with deionized water, drain, and then add 5 times the amount of water to decoct for 7 hours , filtered; filter residue was added to 6 times of water and decocted for 7 hours, filtered; filter residue was added to 3 tim...

Embodiment 2

[0032] A dendrobium eye drop, which is composed of the following components in mass percentage: 40% of Dendrobium nobile, 23% of Danpi, 8% of Shichangpu, 2% of Atractylodes macrocephala, 6% of Cnidium, 7% of Magnolia, and 2% of chitosan , Vitamin B 12 Powder 1%, Vitamin B 1 3%, normal saline 8%.

[0033] Preparation:

[0034] (1). Weigh the prescription amount of dendrobium, mix the dendrobium with a hydrochloric acid solution with a concentration of 0.5mol / L according to the mass ratio of 1:3, soak for 3 hours; then wash with deionized water and drain; then put it at -40°C Freeze in the cold storage for 30 hours, take it out, mix it with the prescription amount of paeonol, add 2 times of absolute ethanol to soak for 2 hours; then wash with deionized water, drain, then add 5 times of water to decoct for 6 hours, and filter; Add 5 times more water to the filter residue and decoct for 7 hours, filter; add 3 times more water to the filter residue, decoct for 2 hours, filter, a...

Embodiment 3

[0038] A dendrobium eye drop, which is composed of the following components in mass percentage: 65% of Dendrobium Huoshanense, 12% of paeonol, 5% of Shichangpu, 2% of Atractylodes macrocephala, 6% of Cnidium, 3% of magnolia, 2% of chitosan, Vitamin B 12 Powder 1%, Vitamin B 1 1%, saline 3%.

[0039] The preparation method is as follows:

[0040] (1). Weigh the dendrobium of the prescription amount, mix the dendrobium with the hydrochloric acid solution with a concentration of 0.5mol / L according to the mass ratio of 1:2, soak for 3 hours; then wash with deionized water and drain; then put it into -35 Freeze in a cold storage at ℃ for 20 hours, take it out, mix it with the prescribed amount of paeonol, add 3 times the amount of absolute ethanol to soak for 2 hours; then wash with deionized water, drain, and then add 3 to 5 times the amount of water to decoct for 6 hours , filtered; the filter residue was decocted for 7 hours by adding 3 times of water, and filtered; the filte...

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Abstract

The invention belongs to the technical field of medicine product processing, and in particular relates to dendrobe eye drops and a preparation method thereof. The dendrobe eye drops consist of the following components in percentage by mass: 40 to 65 percent of dendrobe, 10 to 23 percent of the root bark of the peony tree, 5 to 8 percent of rhizoma acori graminei, 2 to 10 percent of bighead atractylodes rhizome, 6 to 10 percent of fructus cnidii, 3 to 7 percent of biond magnolia flower, 2 to 5 percent of chitosan, 1 to 3 percent of vitamin B12 powder, 1 to 3 percent of vitamin B1 and 3 to 8 percent of normal saline. The dendrobe eye drops provided by the invention adopts the common traditional Chinese medicine components, is reasonable in compatibility and safe and reliable in medicine, has antibacterial and anti-inflammation effects, has remarkable treatment effect on eye diseases such as bacterial conjunctivitis and keratitis, and has the characteristics of exact curative effect, quick response, high curative ratio, no side effect and the like; and the preparation of the dendrobe eye drops is capable of storing effective components in the raw materials, reasonable in production process and suitable for industrialized production.

Description

technical field [0001] The invention relates to the technical field of medicine processing, in particular to a dendrobium moisturizing eye drop and a preparation method thereof. Background technique [0002] Common clinical infectious eye diseases, such as conjunctivitis and keratitis, are mostly bacterial infections, and bacterial keratitis is the number one cause of blindness. A large number of clinical etiological analyzes have shown that the pathogenic bacteria of bacterial keratitis are mainly Staphylococcus epidermidis, Staphylococcus aureus, Pseudomonas aeruginosa, etc., and the main pathogenic bacteria of bacterial conjunctivitis are Staphylococcus epidermidis, aureus Staphylococcus, Escherichia coli, etc. [0003] The traditional Chinese medicine eye drops that are currently used for the treatment of eye diseases has gained widespread attention due to the advantages of low raw material prices and low side effects, but the following problems still exist in the prior...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8984A61K9/08A61P27/02A61P31/04A61P31/02A61K33/14A61K31/722A61K31/714A61K31/51
CPCA61K9/0048A61K9/08A61K31/51A61K31/714A61K31/722A61K33/14A61K36/234A61K36/284A61K36/575A61K36/65A61K36/71A61K36/888A61K36/8984A61K2236/331A61K2236/37A61K2236/39A61K2236/51A61K2300/00
Inventor 李玉萍戴好富蔡彩虹
Owner 海南诗博丽生物科技有限公司
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