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Preparation method of grouped saponin from allium macrostemon

A kind of technology of Xingbai and saponins, which is applied in the field of extracting and separating saponins, and preparing saponins of Xingbai grouping

Inactive Publication Date: 2017-10-27
吉林瑞诺科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no bibliographical report on the preparation of a mixture of furostanoid steroidal saponins and a mixture of spirosteroidal steroidal saponins, i.e., total furostanol saponins from Allium scallops and the preparation of total spirosteroid saponins

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 3 kg of dried Allium scallops and grind them, decoct and extract them with 10 times of water for 3 times, the decoction time is 3h, 2h, 1h respectively, combine the extracts, filter, concentrate, pass through D101 macroporous adsorption resin column for adsorption, and use 35% ethanol solution The furostanol saponins were completely eluted, and then the spirostanoid saponins were completely eluted with 85% ethanol solution, the solvent was recovered under reduced pressure, and dried to obtain 24.2 grams of total furostanol saponins of Scallopsia officinalis and 27.0 grams of total spirostanoids of Scallopsia officinalis. The results of biological activity research showed that the above-mentioned total furostanoid saponins from Sorrelba and total spirosterol saponins from Sorrelba all had anti-platelet aggregation activity, and the activity of total furostanol saponins from Sorrelba was stronger than that from total spirosterol saponins from Sorrelba.

Embodiment 2

[0024] Take 3 kg of dried Allium officinalis aerial part and crush it, decoct and extract it with 10 times of water for 3 hours, 2 hours and 1 hour respectively, combine the extracts, filter, concentrate, pass through D101 macroporous adsorption resin column for adsorption, and use 35% of Ethanol solution completely eluted furostanoid saponins, and then 85% ethanol solution completely eluted spirostanoid saponins. The solvent was recovered under reduced pressure and dried to obtain 22.3 grams of total furostanoid saponins of Sorrelba and 24.5 grams of total snail saponins of Sorrelba.

Embodiment 3

[0026] Take 3 kg of dried Allium scallops and crush them, decoct them with 10 times of water and extract them three times. Wash with water until colorless, use 35% ethanol solution to elute furostanoid saponin completely, then use 85% ethanol solution to elute spirosterol saponin completely, recover solvent under reduced pressure, and dry to obtain 23.2 grams of total furostanol saponins of Scallopsia officinalis. Total spirosterol saponins 26.6 grams.

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PUM

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Abstract

The invention discloses a method for extracting and separating total allium macrostemon furostanol saponin and total allium macrostemon spirostanol saponin. The method comprises the following steps: adsorbing an allium macrostemon extract with macroporous adsorption resin; eluting with an aqueous solution of a low-concentration organic solvent to obtain the total allium macrostemon furostanol saponin mainly composed of furostanol saponin; and then eluting with a high-concentration organic solvent to obtain the total allium macrostemon spirostanol saponin mainly composed of spirostanol saponin.

Description

technical field [0001] The invention relates to a method for extracting and separating saponins from Xiebai, in particular to a preparation method of Xiebai grouped saponins, and belongs to the field of traditional Chinese medicine or natural medicinal chemistry research. Background technique [0002] Xiebai refers to the dried bulb of Allium macrostemon Bge. of the Liliaceae plant. Excavated in summer and autumn, washed, removed fibrous roots, steamed or scalded in boiling water, and sun-dried. It has the functions of dispelling yang and dissipating knots, promoting qi and stagnation; it is used for chest pain and heartache, fullness and pain in the wrist and abdomen, and heavy after diarrhea and dysentery. [0003] So far, a variety of steroidal saponins have been isolated from Xiebai, including furosteric steroidal saponins and spirosteroidal steroidal saponins, which are the main active components of Xiebai. The furosteric steroidal saponins and spirosteroidal steroida...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8962A23L33/105A61K125/00
CPCA23L33/105A23V2002/00A61K36/8962A61K2236/55A23V2200/30A23V2250/21
Inventor 金永日李绪文桂明玉
Owner 吉林瑞诺科技有限公司
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