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Measurement experiment system of human alveolar aerosol deposition

An experimental system, alveolar gas technology, applied in the analysis of materials, instruments, etc., can solve the problem of inability to conduct inhalable particle deposition experiments

Pending Publication Date: 2017-10-20
SANITARY EQUIP INST ACAD OF MILITARY MEDICAL SCI PLA
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Problems solved by technology

Although this patent provides an idea to establish an elastic lung acinar model, it can only simulate and reproduce the breathing process, and cannot conduct experiments on the deposition of inhalable particles in the lung acinar area

Method used

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  • Measurement experiment system of human alveolar aerosol deposition
  • Measurement experiment system of human alveolar aerosol deposition
  • Measurement experiment system of human alveolar aerosol deposition

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Embodiment Construction

[0015] The present invention will be further described below in conjunction with specific examples.

[0016] The standard particle generating device of the present invention takes the F9531 standard particle generating device as an example, which is commercially available. However, it does not limit the present invention.

[0017] Aerosol particle counters are commercially available.

[0018] According to the Weibel A anatomical model, the diameter, length, branching angle, alveolar size and J.Y.Wang's alveolar biomechanical parameters are determined to determine the diameter, length, branch angle, and J.Y.Wang's alveolar biomechanical parameters of the pulmonary acinus adjacent to the 15-17 grade fine bronchus to establish a real human lung acinar model. Equipped with standard particle generators, aerosol particle counters, simulated breathing pumps, humidifiers, PIV particle tracers, etc., it provides a model that can measure the deposition rate, deposition distribution, si...

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Abstract

The invention discloses a measurement experiment system of human alveolar aerosol deposition. A standard particle generator and an expiratory aerosol particle counter are connected with a one-way inlet valve through a pipe respectively; a mains pipe after the one-way inlet valve joins a pipe connected with a humidifier through the pipe penetrates a cover of a transparent experiment container and is connected with a pulmonary acinus experiment model arranged in the transparent experiment container, and the bottom of the transparent experiment container is connected with a simulated respiratory pump through a pipe; a pressure gauge is arranged on the transparent experiment container; an expiratory aerosol particle counter is connected with a one-way exhaust valve and the mains pipe through a pipe sequentially; a computer equipped with a data analysis system is electrically connected with a PIV particle tracer and the simulated respiratory pump, and the PIV particle tracer is arranged on one side of the transparent experiment container. The system can provide external measurement of the deposition rate of inhalable particulate matter under conditions of different particulate sizes, respiratory modes as well as different environmental humidity and pathological conditions.

Description

technical field [0001] The invention belongs to the technical fields of biomedical engineering, sanitation protection and epidemic prevention technology and equipment, man-machine-environment system engineering, respiratory fluid mechanics and personal respiratory protection, and specifically relates to an experimental system for measuring human alveolar aerosol deposition. Background technique [0002] With the accelerated development of global industrialization, air pollution has made respiratory diseases a common and frequently-occurring disease, and the deposition of inhalable particulate matter (airborne particulate matter with an aerodynamic diameter <10 μm) in the lungs is one of the main causes. The human respiratory system consists of the respiratory tract (nose, pharynx, larynx, trachea, bronchi) and lungs. The main function of the respiratory tract is the passage of gas, which communicates between the lungs and the external environment. After the inhalable par...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/04
CPCG01N15/04
Inventor 徐新喜李蓉赵秀国苏琛牛福崔向东王金武
Owner SANITARY EQUIP INST ACAD OF MILITARY MEDICAL SCI PLA
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