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Targeted nanoparticle carrier for carrying bladder cancer treating drug and preparation method and application thereof

A nanoparticle and cancer treatment technology, applied in the field of nanomaterial technology and biomedical materials, can solve the problems of low targeting and different amount of drug-carrying carriers, and achieve reduced dosage, precise killing, and high biocompatibility. Effect

Inactive Publication Date: 2017-10-20
SHANGHAI LINKCHEM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] After reviewing patents and literature, it is concluded that the targeting of nano-PB carrier particles studied at this stage is too low, and the amount of drug loaded on the carrier is different.

Method used

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  • Targeted nanoparticle carrier for carrying bladder cancer treating drug and preparation method and application thereof
  • Targeted nanoparticle carrier for carrying bladder cancer treating drug and preparation method and application thereof
  • Targeted nanoparticle carrier for carrying bladder cancer treating drug and preparation method and application thereof

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Embodiment 1

[0035] Formulated with 2M FeCl 2 4H 2 O, 1M FeCl 3 6H 2 Mixed iron salt solution of O and 2M HCl, deoxygenated with nitrogen for 10 min. in N 2Under certain conditions, the mixed iron salt solution was added dropwise into 250 mL of an oxygen-free ammonia solution with a concentration of 0.7 M, and vigorously stirred at room temperature for 30 min. Magnet separation, washing with ultrapure water to neutrality, constant volume 250mL volumetric flask, sealed storage to obtain Fe 3 o 4 MNPs stock solution.

Embodiment 2

[0037] Formulated with 0.04M FeCl 3 ·6H 2 O with 20 μL of 30% H 2 o 2 40mL of the mixed aqueous solution is recorded as solution A; the preparation contains 0.04M K 3 Fe(CN) 6 with 20 μL of 30% H 2 o 2 40mL of the mixed aqueous solution is recorded as solution B; under stirring, solution A is slowly added dropwise to solution B, and then 20mL of Fe 3 o 4 MNPs stock solution, stirred for 3 h, solution containing magnetic Prussian blue nanoparticles. The colloidal solution was taken out, magnetically separated and washed, and the separated product was dried in a vacuum oven to obtain powdered PBMNPs.

Embodiment 3

[0039] Under magnetic stirring, a polyvinylpyrrolidone (PVP) aqueous solution with a concentration of 5 mg / mL was added to a polytetrafluoroethylene container containing a PBMNPs solution with a concentration of 1 mg / mL. After about 3 hours, the solution was placed in a 140°C electric furnace Place in a stainless steel autoclave for 4 hours. After the reaction, centrifugation was carried out, and after centrifugation, the precipitate was washed several times in distilled water. Hollow nanoparticle carriers (HPBMNPs) were obtained after freeze-drying.

[0040] PBMNPs and HPBMNPs were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). figure 1 , where a is the SEM and TEM images of PBMNPs; b and c are the SEM and TEM images of HPBMNPs, respectively. It can be seen that the particle size of the synthesized HPBMNPs is about 100nm, with a hollow of about 90nm, and the micropores in it are less than 2nm, which is similar to the particle...

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Abstract

The invention discloses a targeted nanoparticle carrier for carrying bladder cancer treating drug and a preparation method and application thereof. The nanoparticle carrier takes magnetic ferroferric oxide as a core, the surface of the core is wrapped with a Prussian blue nano shell, and a shell layer of the carrier is provided with hollow pores uniform in size. Compared with existing drug carriers, the nanoparticle carrier has high biocompatibility; the nanoparticle carrier after being loaded with drug can be passively devoured by cells, and an in-vitro magnetic field can be arranged to realize magnetic targeted distribution of in-vivo drug so as to release the drug more accurately to kill and damage cancer cells; drug consumption is reduced greatly, so that toxic and side effect is lowered greatly. Nanoparticles of this type have great potential in development of drug nano carriers in the future.

Description

technical field [0001] The invention relates to the technical fields of nanomaterial technology and biomedical material, in particular to the preparation and application of a magnetically targeted hollow Prussian nanoparticle carrier (HPBMNPs) for carrying bladder cancer therapeutic drugs. Background technique [0002] Cancer is a general term for various malignant tumors and a major disease that threatens human health. Traditional treatments include surgery, radiation and chemotherapy. Traditional surgery is used to remove benign and non-spread tumors in the early stage, but the disadvantage is that the tumor may not be completely removed and may cause recurrence. Radiation therapy uses high-energy rays to kill tumors to achieve the purpose of treating tumors. In the early stage of treatment, a large number of tumor cells can be killed, and a small number of mutated tumor cells continue to survive and proliferate, which eventually leads to the failure of radiotherapy. Che...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K41/00A61K47/02A61K47/32A61K33/24A61P35/00
CPCA61K9/0009A61K9/5115A61K9/5138A61K33/24A61K41/00
Inventor 陆茜
Owner SHANGHAI LINKCHEM TECH CO LTD
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