Synthetic method for preparing Niraparib
A synthesis method and technology of synthesis route, which are applied in the synthesis field for preparing Niraparib, can solve the problems of difficulty in realizing large-scale industrial production, restricting industrial safety production, long synthesis route, etc., and achieve large-scale production, easy mass production, The effect of easy control of operating conditions
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0037] Niraparib intermediate 1 Synthesis
[0038]The synthesis of Niraparib intermediate 1 is carried out in two steps, the first step (esterification): 3-methyl-2-nitrobenzoic acid and methyl alcohol are pressed by n (3-methyl-2-nitrobenzoic acid): The ratio of n (methanol) = 1:5, that is, take 182g of 3-methyl-2-nitrobenzoic acid, place 160.2g of methanol in a conical flask with a reflux device, heat slowly, and wait for 3-methyl-2- After the nitrobenzoic acid was completely dissolved in methanol, 6 mL of concentrated sulfuric acid was added, and the temperature was raised to 58°C for the reaction. The product was methyl 3-methyl-2-nitrocarboxylate (Niraparib intermediate 1) and water. The generated Niraparib intermediate 1 is subjected to the second step (refinement and extraction): after the esterification reaction is completed, after the temperature of the reaction solution drops to room temperature, adjust the pH of the solution to neutral with sodium bicarbonate, and...
PUM
![No PUM](https://static-eureka-patsnap-com.libproxy1.nus.edu.sg/ssr/23.2.0/_nuxt/noPUMSmall.5c5f49c7.png)
Abstract
Description
Claims
Application Information
![application no application](https://static-eureka-patsnap-com.libproxy1.nus.edu.sg/ssr/23.2.0/_nuxt/application.06fe782c.png)
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap