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Antihypertensive drug composition and application thereof

A composition and technology for lowering blood pressure, which can be used in drug combinations, pharmaceutical formulas, cardiovascular diseases, etc., can solve the problems of no literature reports, and achieve a synergistic effect of lowering blood pressure

Inactive Publication Date: 2017-09-29
YANTAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The use of sulfonylurea secretagogues for the treatment of hypertension, especially in combination with bumetanide, has not been reported in the literature

Method used

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  • Antihypertensive drug composition and application thereof
  • Antihypertensive drug composition and application thereof
  • Antihypertensive drug composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 compound tablet

[0025]

[0026] Appropriate amount of 5% PVP in absolute ethanol solution

[0027] Preparation method: first put Gliquizone and Bumetanide into a mortar, grind and mix evenly, then add cornstarch and microcrystalline cellulose in turn, mix evenly, use 5% PVP absolute ethanol solution as binder to granulate, Dry at 40°C, granulate, add magnesium stearate, mix evenly, and compress into tablets.

Embodiment 2

[0028] The preparation of embodiment 2 compound tablet

[0029]

[0030]

[0031] Preparation process: First put Gliquizone and Bumetanide into a mortar, grind and mix evenly, then add hydroxymethyl cellulose and talc powder in turn, mix evenly, use 5% starch slurry to granulate in an appropriate amount, dry at 40°C, and granulate , add magnesium stearate, mix well, press into tablets, and obtain.

Embodiment 3

[0032] The preparation of embodiment 3 compound capsule

[0033]

[0034] Preparation process: Gliquizone and β-cyclodextrin are first put into a mortar, ground and mixed evenly, then carboxymethylcellulose and talcum powder are added in turn, mixed evenly, and finally bumetanide is added to mix evenly, and the capsule shell is filled. Instantly.

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PUM

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Abstract

The invention relates to an antihypertensive drug composition, which comprises gliguidone and bumetanide. A hypoglycemic drug gliguidone is introduced on the basis of a diuretic antihypertensive drug bumetanide, so that collaborative depressurization is achieved and the effect is significantly strengthened. When a fixed compound is formed, the dosage of various single drugs is reduced, and especially the dosage of the bumetanide is greatly reduced, so that the incidence rate of the side effect of the drug is reduced; and protection of the heart is facilitated while hypertension is treated, the damage of the hypertension to the hearth function is significantly reduced, the gliguidone combined with bumetanide has a significant difference in reverse or reduction of left ventricular hypertrophy, and a collaborative treatment effect is obtained.

Description

technical field [0001] The present invention relates to a medicine composition for lowering blood pressure, in particular to a medicine composition containing gliquizone and bumetanide. Background technique [0002] Hypertension (HTN) refers to an increase in arterial systolic or diastolic blood pressure in a resting state. Systemic chronic disease with functional or organic changes. At present, hypertension has a high incidence rate in my country and is the main factor causing cardiovascular and cerebrovascular diseases. Moreover, the prevalence of hypertension in my country has become higher and higher in the past ten years. According to the 2002 National Nutrition and Health Survey, the prevalence of hypertension in adults in my country has reached 18.8%. Compared with 1991, the number of patients has increased. The number of hypertensive patients in the country reached 160 million, which means that 1 out of every 5 adults is a hypertensive patient. The survey in 2004 i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/64A61K31/196A61P9/12
CPCA61K31/64A61K31/196A61K2300/00
Inventor 高永林李春梅乔俊花
Owner YANTAI UNIV
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