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Mono-dispersed core-shell type polymer chromatography medium with porous surface and preparation method of chromatography medium

A porous polymer, surface porous technology, applied in alkali metal compounds, chemical instruments and methods, other chemical processes, etc., can solve the problems of narrow pH range, weak mechanical stability, easy detachment of ligands, etc., to achieve wide application pH range, long service life, good separation effect

Inactive Publication Date: 2017-09-15
NINGXIA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the silica gel monolithic column has the disadvantages of radial inhomogeneity, poor reproducibility between batches of products, and weak mechanical stability; the polymer monolithic column also has the problems of swelling to organic solvents and low column efficiency for small molecule separation. These deficiencies limit the development of monolithic columns
The surface porous core-shell fillers are all silica gel materials in the current market. The common surface porous core-shell fillers are composed of non-porous silica gel cores and porous silica gel shells. Although silica gel materials have high mechanical strength, surface modifier varieties There are many advantages, but at the same time, there are also disadvantages such as narrow applicable pH range and easy shedding of ligands.

Method used

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  • Mono-dispersed core-shell type polymer chromatography medium with porous surface and preparation method of chromatography medium
  • Mono-dispersed core-shell type polymer chromatography medium with porous surface and preparation method of chromatography medium
  • Mono-dispersed core-shell type polymer chromatography medium with porous surface and preparation method of chromatography medium

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preparation example Construction

[0025] A preparation method of a monodisperse surface porous core-shell polymer chromatographic medium, comprising the following steps:

[0026] S1: Preparation of non-porous polymer core:

[0027] Mix the preparation monomer A, initiator A, stabilizer A, and reaction medium A into a mixed solution, the mixed solution includes 20 parts by mass of the prepared monomer A, 0.5 parts by mass of the initiator A, and 1 part by mass of the stabilizer A, The reaction medium A of 78.5 mass parts, wherein preparation monomer A is styrene, initiator A is benzoyl peroxide, stabilizer A is polyvinylpyrrolidone, reaction medium A is dehydrated alcohol, mixed solution is ultrasonicated to transparent, Then pass through nitrogen for 10 minutes, then place the mixed solution on a rotating and heating device at 120 rpm, and carry out dispersion polymerization at 60-80°C for 12-24 hours to obtain a mixture containing polystyrene non-porous microspheres, The solid particles in the mixture contai...

Embodiment 1

[0032] A preparation method of a monodisperse surface porous core-shell polymer chromatographic medium, comprising the following steps:

[0033]S1: Preparation of non-porous polymer core:

[0034] Mix 20 grams of prepared monomer A styrene, 0.5 grams of initiator A benzoyl peroxide, 1 gram of stabilizer A polyvinylpyrrolidone, and 100 mL of reaction medium A absolute ethanol to form a mixed solution, and the mixed solution is sonicated to Transparent, that is, it is completely dissolved, and then nitrogen gas is introduced for 10 minutes, then the mixed solution is placed on a rotating and heating device at 120 rpm, and the dispersion polymerization reaction is carried out at 70°C for 24 hours to obtain polystyrene non-porous microspheres. The mixture, the solid particles in the mixture containing the polystyrene nonporous microspheres are the polystyrene nonporous microspheres.

[0035] The solvent in the obtained mixture containing polystyrene non-porous microspheres is rem...

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Abstract

The invention relates to a mono-dispersed core-shell type polymer chromatography medium with a porous surface and a preparation method of the chromatography medium. The chromatography medium comprises an imporous polymer core and a porous polymer shell layer and can be used for controllably preparing a polymer shell layer hole structure. The preparation method comprises the following steps: firstly preparing a micro-scale mono-dispersed imporous polymer microsphere as a core; preparing a superfine emulsion from monomers, a cross-linking agent, an initiator and a pore-foaming agent, and enabling an organic phase to be uniformly attached to the surface of the imporous core; and finally separating an organic phase layer from the surface of the imporous core through solidification by virtue of thermal initiation polymerization reaction, so as to obtain the mono-dispersed core-shell type polymer chromatography medium with the porous surface.

Description

technical field [0001] The invention relates to the field of high-performance liquid chromatography stationary phase, in particular to a monodisperse surface porous core-shell polymer chromatography medium and a preparation method thereof. Background technique [0002] High-performance liquid chromatography (HPLC) has become an important means of separation and analysis of complex samples due to its advantages of high efficiency, high speed, and high resolution. widely used. Efficient and rapid separation analysis is always the goal pursued by chromatographers. [0003] In recent years, ultra-high pressure liquid chromatography technology based on sub-2 micron chromatographic packing and rapid separation technology based on surface porous core-shell packing have brought HPLC into a new era of rapid analysis. Although sub-2 micron packings show obvious advantages for rapid separation by HPLC, there are great limitations in achieving higher separation efficiency by further r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F112/08C08F2/08C08F220/32C08F222/14C08F2/20B01J20/26B01J20/285B01J20/28B01J20/30
CPCB01J20/264B01J20/28021B01J20/285C08F2/20C08F112/08C08F220/32C08F220/325C08F222/1006C08F222/102C08F2/08
Inventor 杨帆张莲
Owner NINGXIA UNIVERSITY
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