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Broad-spectrum anti-parasitic compound imidacloprid transdermal composition preparation for pets

An anti-parasite and imidacloprid technology, applied in the direction of drug combination, non-active ingredient medical preparations, medical preparations containing active ingredients, etc., to prolong the absorption process and action time, reduce the frequency of administration, and reduce the effect of side effects

Active Publication Date: 2017-09-15
成都导飞科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] At present, there is no broad-spectrum anti-parasitic transdermal preparation for pets that includes imidacloprid, doramectin and pyrethroid compounds at the same time, and is easy to administer and effective for a long time

Method used

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  • Broad-spectrum anti-parasitic compound imidacloprid transdermal composition preparation for pets
  • Broad-spectrum anti-parasitic compound imidacloprid transdermal composition preparation for pets
  • Broad-spectrum anti-parasitic compound imidacloprid transdermal composition preparation for pets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-12

[0050] Table 1. Example 1-12 formulations.

[0051]

[0052] The preparation method comprises the following steps: dissolving imidacloprid in a prescription amount with an appropriate amount of solvent to prepare solution A; dissolving doramectin in an appropriate amount in a prescription to prepare solution B; taking fenvalerate in a prescription amount for Dissolve an appropriate amount of solvent to make solution C; mix solution A, solution B and solution C, make up the prescribed amount of solvent, add the prescribed amount of penetration enhancer and antioxidant, and use auxiliary agents to make up the volume; Filter through a microporous membrane of 0.22 μm, and fill it after passing the clarity.

experiment example 1

[0054]In vitro transdermal experiment of the compound imidacloprid transdermal combination preparation of Example 1 (containing 12.5% ​​imidacloprid, 0.25% doramectin, and 0.005% fenvalerate).

[0055] 1. Experimental method.

[0056] 1.1. Reagents and instruments.

[0057] The compound imidacloprid transdermal combination preparation was prepared in Example 1, containing 12.5% ​​imidacloprid, 0.25% doramectin, and 0.005% fenvalerate.

[0058] Franz diffusion cell (Sichuan University), BP211D electronic balance (Sartorius company, Germany), JA3003 electronic balance (Shanghai Analytical Instrument Factory), DF-101S collector type constant temperature heating magnetic stirrer (Gongyi City Yuhua Instrument Co., Ltd.), HL-2 constant current peristaltic pump (Shanghai Qingpu Huxi Instrument Factory), QZX-C air bath oscillator (Harbin Dongming Medical Instrument Factory).

[0059] 1.2. In vitro transdermal test method.

[0060] 1.2.1. Preparation of isolated skin: Take a piece o...

experiment example 2

[0085] Comparison of transdermal superiority of compound imidacloprid transdermal combination preparations.

[0086] 1. Experimental method.

[0087] 1.1. Reagents and instruments.

[0088] Compound imidacloprid transdermal combination preparation 1 is prepared in Example 1, containing 12.5% ​​imidacloprid, 0.25% doramectin, and 0.005% fenvalerate; the solvent is benzyl alcohol, and the auxiliary agent is ethanol. The compound imidacloprid transdermal combination preparation comparative preparation 1, comparative preparation 2 and comparative preparation 3 are prepared from comparative example 1, comparative example 2 and comparative example 3 respectively, the solvents are respectively propylene glycol, isopropanol and n-butanol, and the auxiliary agent is ethanol .

[0089] The instrument is the same as Item 1.1 in Example 13.

[0090] 1.2. In vitro transdermal test method.

[0091] With item 1.2 in embodiment 13.

[0092]1.3. Drug assay methods.

[0093] With item 1.3...

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Abstract

The invention discloses a broad-spectrum anti-parasitic compound imidacloprid transdermal composition preparation for pets. The transdermal composition preparation contains the following components in parts by weight: 500000-5000000 parts of imidacloprid, 1000-500000 parts of doramectin, 100-20000 parts of pyrethroid, 2000000-8000000 parts of a solvent, 100000-2000000 parts of a penetration enhancer, 1-10 parts of an antioxidant, 500000-5000000 parts of an auxiliary agent. The compound imidacloprid transdermal composition preparation is stable in quality, high in safety, good in transdermal absorption property, good in pesticide effect, good in pesticide effect, low in stimulation, simple and convenient to use and low in environmental pollution, has a relatively long slow release period, can be used for expelling and killing endoparasite and ectoparasite, and simultaneously has functions of preventing mosquitoes and fleas.

Description

technical field [0001] The invention relates to a broad-spectrum anti-parasitic compound imidacloprid transdermal composition preparation for pets and a preparation method thereof. It belongs to the field of veterinary medicine. Background technique [0002] With the improvement of people's living standards, the growing spiritual needs have triggered a pet fever. Pets not only bring a lot of fun to the ordinary life of human beings, but also many people use pets as an emotional support to relieve loneliness and depression, and relieve psychological pressure. However, the contact between pets and the external environment will inevitably infect certain parasites, and people will inevitably have close contact with pets in the common life with pets, which increases the possibility of zoonotic parasitic diseases. Parasites can transmit a variety of diseases, causing harm to the health of pets and humans, and even death in severe cases. [0003] Imidacloprid is a neonicotinoid ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4439A61K31/7048A61K31/222A61K31/277A61P33/14A61P33/10A61K9/08A61K47/10A61K47/22A61K47/20
CPCA61K9/0017A61K9/08A61K31/222A61K31/277A61K31/4439A61K31/7048A61K47/10A61K47/20A61K47/22A61K2300/00
Inventor 张凌
Owner 成都导飞科技有限公司
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