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A kind of separation and preparation method of Guangdong purple pearl extract and its application

A technology of extracts and motherwort extracts, applied in medical preparations containing active ingredients, plant/algae/fungus/moss components, pharmaceutical formulas, etc., can solve problems such as UC and other immune inflammations that have not been discovered

Active Publication Date: 2021-05-14
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

We used membrane separation technology combined with macroporous resin column separation method to separate and prepare the active substance group with anti-UC activity from Guangdong Zizhu and its compound extract. So far, no information about the separation and preparation of this active ingredient group and its treatment has been found. Literature reports on UC and other immune inflammation

Method used

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  • A kind of separation and preparation method of Guangdong purple pearl extract and its application
  • A kind of separation and preparation method of Guangdong purple pearl extract and its application
  • A kind of separation and preparation method of Guangdong purple pearl extract and its application

Examples

Experimental program
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Effect test

example 1

[0034] Example 1. Separation and preparation of anti-ulcerative colitis medicine of the present invention.

[0035] Separation and preparation method of effective group with anti-ulcerative colitis activity in Guangdong Zizhu dry extract:

[0036] Preparation of Guangdong Zizhu dry extract: take Guangdong Zizhu, moisten thoroughly, cut into small sections or slices, add water to decoct twice, the first time for 3 hours, the second time for 2 hours, filter, combine the filtrates, and concentrate the filtrate to Thick paste, dried under reduced pressure.

[0037]Dissolve the dry extract of Guangdong Zizhu in water, the weight ratio of solid to liquid is 1:40, centrifuge at 5000r / min for 10min to obtain the supernatant; pass through a 0.2um microfiltration system; pass the obtained permeate through a 100k Da ultrafiltration membrane, pressure 0.05MPa, ultrafiltration until the cut-off volume is 1 / 5 of the total volume of the original solution, adding an equal volume of water to ...

example 2

[0038] Example 2, the separation and preparation of the anti-ulcerative colitis medicine of the present invention.

[0039] Preparation method of anti-ulcerative colitis active effective group in traditional Chinese medicine compound:

[0040] Preparation of Guangdong Zizhu dry extract: Take Guangdong Zizhu, moisten thoroughly, cut into small sections or slices, add water to decoct twice, the first time for 3 hours, the second time for 2 hours, filter, combine the filtrates, and concentrate the filtrate to Thick paste, dried under reduced pressure, that is. Preparation of motherwort dry extract: take motherwort, chop it, add water to decoct twice for 2 hours each time, filter, combine the filtrates, concentrate the filtrate to a thick paste, and dry under reduced pressure to obtain. Preparation of dry extract of black yao yao: take black yao yao, add water to decoct twice, each time for 2 hours, filter, combine the filtrates, concentrate the filtrate into a thick paste, dry u...

example 3

[0042] Example 3, the influence of anti-ulcerative colitis drug of the present invention on mouse UC model

[0043] 1. Test materials

[0044] 1.1 Drugs and dosage

[0045] Experimental drugs include 7 test drugs and sulfasalazine as positive control drugs, the specific dosage is shown in Table 1

[0046] Table 1. Tested drugs and dosage

[0047]

[0048] Test drug No. 1: the raw material used in the separation and preparation in Example 1, that is, the dry extract of Guangdong Zizhu, wherein the polysaccharide content of Guangdong Zizhu is 25.21%, and the content of phenylethanol glycoside is 6.3%. The test drug is the raw material prepared separately.

[0049] Test drug No. 2: the final product obtained by separating and preparing test drug No. 1 in the manner described in Example 1, wherein the polysaccharide content of Guangdong Zizhu is 64.52%, and the content of phenylethanol glycoside is 15.84%.

[0050] No. 3 test drug: the raw material used in the separation an...

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Abstract

The present invention relates to the preparation method of the effective substance group with anti-ulcerative colitis activity obtained from Guangdong Zizhu and its compound extract, and the application of the drug in the preparation of drugs for the treatment of immune inflammation. The core separation technology obtains effective substance groups for the preparation and treatment of immune inflammation including ulcerative colitis.

Description

technical field [0001] The invention discloses a traditional Chinese medicine extract for treating ulcerative colitis, which belongs to the field of traditional Chinese medicines. Background technique [0002] Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease that belongs to the category of autoimmune diseases. Because UC is difficult to cure, and is prone to recurrence, deterioration and canceration, it brings great physical and mental pain to patients, and has been listed as one of the modern intractable diseases by the World Health Organization (WHO). So far, the therapeutic drugs for UC mainly include traditional aminosalicylates, steroid hormones, immunosuppressants, and new biological agents. The therapeutic effect of traditional therapeutic drugs is limited, and the recurrence rate is high after drug withdrawal. New biological agents (such as tumor necrosis factor-α (TNF-α) monoclonal antibody), although they can relieve intestinal inflammation a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/85A61P1/00A61P1/04
CPCA61K36/533A61K36/54A61K36/85A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 刘丽芳程贤辛贵忠
Owner CHINA PHARM UNIV
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