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Callicarpa kwangtungensis extract separation preparation method and application of callicarpa kwangtungensis extract

A technology of extracts and purple beads, applied in medical preparations containing active ingredients, plant/algae/fungus/moss components, pharmaceutical formulas, etc., can solve the problems of immune inflammation such as UC that have not been found, and achieve strong promotion and application The effect of value, mild conditions, and simple methods

Active Publication Date: 2017-09-12
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

We used membrane separation technology combined with macroporous resin column separation method to separate and prepare the active substance group with anti-UC activity from Guangdong Zizhu and its compound extract. So far, no information about the separation and preparation of this active ingredient group and its treatment has been found. Literature reports on UC and other immune inflammation

Method used

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  • Callicarpa kwangtungensis extract separation preparation method and application of callicarpa kwangtungensis extract
  • Callicarpa kwangtungensis extract separation preparation method and application of callicarpa kwangtungensis extract
  • Callicarpa kwangtungensis extract separation preparation method and application of callicarpa kwangtungensis extract

Examples

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example 1

[0034] Example 1. Separation and preparation of the anti-ulcerative colitis drug of the present invention.

[0035] Separation and preparation method of effective groups with anti-ulcerative colitis activity in Guangdong Zizhu dry extract:

[0036] Preparation of Guangdong Zizhu dry extract: Take Guangdong Zizhu, moisten it thoroughly, cut into small pieces or slices, add water to decoct twice, the first 3 hours, the second 2 hours, filter, combine the filtrates, and concentrate the filtrates to Thick paste, dried under reduced pressure.

[0037]The Guangdong Zizhu dry extract was dissolved in water, the weight ratio of material to liquid was 1:40, and the supernatant was obtained by centrifugation at 5000r / min for 10min; passed through a 0.2um microfiltration system; the obtained permeate was passed through a 100k Da ultrafiltration membrane, pressure is 0.05MPa, ultrafiltered until the cut-off volume is 1 / 5 of the total volume of the original solution, and the same volume o...

example 2

[0038] Example 2. Separation and preparation of the anti-ulcerative colitis drug of the present invention.

[0039] The preparation method of active and effective group of anti-ulcerative colitis in the traditional Chinese medicine compound:

[0040] Preparation of Guangdong Zizhu dry extract: Take Guangdong Zizhu, moisten it thoroughly, cut into small pieces or slices, add water to decoct twice, the first 3 hours, the second 2 hours, filter, combine the filtrates, and concentrate the filtrates to Thick paste, dried under reduced pressure, and obtained. Preparation of motherwort dry extract: take motherwort, chop into pieces, add water to decoct twice for 2 hours each time, filter, combine the filtrates, concentrate the filtrate to a thick paste, and dry under reduced pressure. Preparation of dried black medicine extract: take black medicine, add water to decoct twice for 2 hours each time, filter, combine the filtrates, concentrate the filtrate into a thick paste, and dry un...

example 3

[0042] Example 3. Effect of the anti-ulcerative colitis drug of the present invention on mouse UC model

[0043] 1. Test materials

[0044] 1.1 Drugs and Dosages

[0045] The experimental drugs include 7 test drugs and sulfasalazine as the positive control drug, the specific dosage is shown in Table 1

[0046] Table 1. Tested Drugs and Dosages

[0047]

[0048] Test drug No. 1: the raw material used for the separation and preparation in Example 1, namely Guangdong Zizhu dry extract, wherein the Guangdong Zizhu polysaccharide content is 25.21%, and the phenylethanoid content is 6.3%. The test drug is the raw material prepared by separation.

[0049] Test drug No. 2: The final product obtained by separating and preparing the test drug No. 1 as the raw material according to the method described in Example 1, wherein the content of Guangdong Zizhu polysaccharide is 64.52%, and the content of phenethyl glucoside is 15.84%.

[0050] Test drug No. 3: the raw material used for ...

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Abstract

The invention relates to a preparation method for acquiring effective substance groups with anti-ulcerative-colitis activity by separation from callicarpa kwangtungensis and compound extract thereof and application of the effective substance groups to preparation of medicines for treating immune inflammations. Particularly, the effective substance groups are acquired by adoption of a membrane separation focused separation technology and used for preparation of medicines for treating immune inflammations including ulcerative colitis.

Description

technical field [0001] The invention discloses a traditional Chinese medicine extract for treating ulcerative colitis, which belongs to the field of traditional Chinese medicine. Background technique [0002] Ulcerative colitis (UC) is a chronic non-specific inflammatory disease that belongs to the category of autoimmune diseases. Because UC is difficult to cure, and is prone to recurrence, deterioration and canceration, it brings great physical and mental pain to patients, and has been listed as one of the modern intractable diseases by the World Health Organization (WHO). So far, the therapeutic drugs for UC mainly include traditional aminosalicylic acids, steroid hormones, immunosuppressants, and new biological agents. Traditional treatment drugs have limited therapeutic effect, and the recurrence rate is high after drug withdrawal. Newer biologics, such as tumor necrosis factor-α (TNF-α) monoclonal antibodies, can alleviate intestinal inflammation and promote mucosal r...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61P1/00A61P1/04
CPCA61K36/533A61K36/54A61K36/85A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 刘丽芳程贤辛贵忠
Owner CHINA PHARM UNIV
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