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High-purity colloidal bismuth pectin compound and confirmation of structural formula, molecular formula and molecular weight thereof

A colloidal bismuth pectin, high-purity technology, applied in the directions of medical preparations containing active ingredients, inorganic active ingredients, organic active ingredients, etc., can solve the problems of low chemical purity of colloidal bismuth pectin and the like

Inactive Publication Date: 2017-09-01
于学敏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The chemical purity of colloidal bismuth pectin prepared by this method is low (<80%), containing a large amount of organic and inorganic impurities

Method used

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  • High-purity colloidal bismuth pectin compound and confirmation of structural formula, molecular formula and molecular weight thereof
  • High-purity colloidal bismuth pectin compound and confirmation of structural formula, molecular formula and molecular weight thereof
  • High-purity colloidal bismuth pectin compound and confirmation of structural formula, molecular formula and molecular weight thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Take 165kg of dry citrus peel particles (particle size 2.5mm-3.5mm), add 1200L of purified water and heat (50-90°C) to soak for 30-60 minutes, centrifuge to remove decolorized water, and then wash with water for 3-4 times. The decolorized wet peel residue is added to dilute HCl aqueous solution (pH 2-2.5), kept at a temperature of 70-90°C for 90-120 minutes, and centrifuged to separate the glue. The glue is removed a small amount of solid suspended matter and solid impurities by a high-speed solid-liquid centrifugal separator to obtain refined glue, which is concentrated under reduced pressure (vacuum degree -0.7MPa, material temperature is about 60°C), so that the volume of the glue is reduced to thin glue 1 / 3rd-1 / 4th, get pectin thick mucilage. Add 11.11 kg of bismuth hydroxide to 100 kg of purified water, heat and stir to disperse into a colloidal solution, add 25 kg of potassium hydroxide (50%) aqueous solution, and fully stir to completely dissolve into a bismuth s...

Embodiment 2

[0061] Preparation of high-purity colloidal bismuth pectin bioadhesive time-lag tablets

[0062] (1) Preparation of bioadhesive composite excipients: take 333.33 g of high-purity colloidal bismuth pectin, another 18.52 g of croscarmellose sodium, 18.52 g of crospovidone, and 35 g of microcrystalline cellulose, add water Make it dissolve, spray dry to make compound auxiliary material.

[0063] (2) Tablet core preparation: mix high-purity bismuth pectin powder and compound excipients evenly, and directly dry (DC) compress the tablet, use this as the tablet core material, and measure the disintegration time limit in 0.1mol / L hydrochloric acid solution, Should be less than 10 minutes.

[0064] (3) Coating: Prepare a mixed solution of ethanol (70%) containing 3% of HPMC and 2% of PEG6000 to coat the isolation layer. A 95% ethanol solution containing EudragitE 100 10%, PVP 6%, and PEG6000 2% was prepared as a lagging layer coating solution for lagging layer coating. The drug prep...

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Abstract

The invention discloses a preparation method of a high-purity colloidal bismuth pectin compound, confirmation of a chemical structural formula, a molecular formula and the molecular weight thereof, and an application technology. The compound is different from a compound prepared by a colloidal bismuth pectin preparation method (patent) disclosed and implemented previously. According to the original patent process, due to reasons of raw materials in an intermediate liquid pectin and a bismuth salt solution for the production of colloidal bismuth pectin and the preparation method thereof, the product contains lots of organic impurities (sorbitol, pectin, etc.) and inorganic impurities (nitrate and bismuth hydroxide), purity of the product is low (only 80%), quality standard level is low, and curative effect is poor. The invention provides several preparation methods for preparation of a high-purity (98%) colloidal bismuth pectin compound, including five optimization methods. Through spectrometry and analysis, the structural formula, the molecular formula and the molecular weight of the compound are determined. A novel medicinal preparation prepared from the high-purity compound has obvious clinical advantages.

Description

technical field [0001] The invention belongs to the field of pharmacy (including raw materials and pharmaceutical preparations). Background technique [0002] Gastrointestinal diseases are common clinical diseases and frequently-occurring diseases, with an incidence rate as high as 40%. Such diseases are prone to relapse, and acute attacks can easily cause gastric bleeding. Chronic atrophic gastritis has a tendency to become cancerous, and it is a category that poses a great threat to human life and health. disease. [0003] Especially since Australian scientists Barry Marshall and Robin Warren discovered that Helicobacter pylori (Hp) is the pathogenic bacteria of gastrointestinal diseases, due to the drug resistance of Hp to multiple antibiotics and the toxic side effects of proton pump causing mucosal atrophy, Bismuth salt compounds have become safe and effective drugs for the treatment of gastrointestinal diseases. [0004] Bismuth salt compounds and bismuth preparation...

Claims

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Application Information

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IPC IPC(8): C08B37/06A61K31/732
CPCC08B37/0045A61K33/245
Inventor 于学敏韩柳韩琴杨鑫伟郝树琴
Owner 于学敏
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