Preparation method of aminomethylbenzoic acid injection

A technology of aminotoluic acid and injection, applied in the field of preparation of aminotoluic acid injection, can solve problems such as inability to block, and achieve the effect of stable product content

Inactive Publication Date: 2017-09-01
SHANGHAI XINYI JINZHU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these antagonists cannot block the activation of activators (such as urokinase, etc.) that have been adsorbed on the fibrin network to form plasmin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A preparation method of aminomethylbenzoic acid injection, comprising the following steps:

[0020] Step 1, add freshly boiled water for injection with a preparation amount of 50% into the concentrated preparation tank, add aminotoluic acid, stir to dissolve; add concentrated hydrochloric acid according to an appropriate amount, and stir evenly;

[0021] Step 2, add medicinal charcoal, stir evenly, filter back with Suzhou sand stick until clear, and filter into the dilute tank;

[0022] Step 3, add water for injection to the full amount, stir for 15 minutes to make it uniform, and adjust the pH value with concentrated hydrochloric acid;

[0023] Step 4, use Suzhou sand filter stick, 0.45μm and 0.22μm fins to back filter until clear;

[0024] Step 5: Sampling and testing the intermediate content and pH value. After all items are qualified, filter the medicinal liquid into the liquid storage tank;

[0025] Step 6, after the medicinal liquid in the liquid storage tank is...

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PUM

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Abstract

The invention discloses a preparation method of aminomethylbenzoic acid injection. In the preparation method, concentrated sulfuric acid is added during the preparation process to ensure stable product content.

Description

technical field [0001] The invention relates to a preparation method of aminomethylbenzoic acid injection. Background technique [0002] Aminomethylbenzoic acid is a procoagulant drug. There are various natural antagonists of plasmin (original) in the blood circulation, such as anti-plasmin and so on. Under normal circumstances, the activity of anti-fibrinolytic substances in the blood is many times higher than that of fibrinolytic substances, so fibrinolytic bleeding will not occur. However, these antagonists cannot block the activation of activators (such as urokinase, etc.) that have been adsorbed on the fibrin network to form plasmin. Plasmin is an endopeptidase that can cleave the arginine and lysine peptide chains of fibrin (ogen) in a neutral environment to form fibrin degradation products and cause blood clots to dissolve and bleed. Plasminogen is specifically adsorbed on fibrin through the lysine binding site in its molecular structure, and lysine can competitive...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/195A61K47/04A61P7/04
CPCA61K9/0019A61K9/08A61K31/195A61K47/02
Inventor 徐欣
Owner SHANGHAI XINYI JINZHU PHARMA
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