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Preparation method for sodium alginate nanometer fiber-based hydrogel

A technology of nanofibers and sodium alginate is applied in the preparation of sodium alginate nanofiber-based hydrogel and the field of preparation of sodium alginate hydrogel, which can solve the complex preparation process, poor extrusion performance index, and biological side effects. and other problems, to achieve the effect of simple preparation method, easy implementation and strong thixotropy

Inactive Publication Date: 2017-08-25
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However, the problem or deficiency of the sodium alginate hydrogel prepared by this divalent ion physical crosslinking method is: the gel can no longer be extruded or processed twice, and the extrusion performance index is poor
The main problems or deficiencies in the sodium alginate hydrogel prepared by chemical crosslinking are: the extrusion performance of the gel is not good; The body produces side effects, and the unreacted cross-linking agent needs to be separated and removed in the later stage. Therefore, the post-treatment process is relatively cumbersome.
The preparation process of this chitosan nanofiber hemostatic material is complicated, and there may be acid and other residual components introduced by it
Moreover, its hemostasis operation is relatively troublesome

Method used

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  • Preparation method for sodium alginate nanometer fiber-based hydrogel
  • Preparation method for sodium alginate nanometer fiber-based hydrogel
  • Preparation method for sodium alginate nanometer fiber-based hydrogel

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] The preparation method is as follows:

[0059] In the first step, use deionized water to prepare a sodium alginate nanofiber solution with a concentration of 0.1% by mass;

[0060] In the second step, while stirring, add NaCl to the above-mentioned nanofiber solution until the concentration of the NaCl (electrolyte) component in the mixed solution reaches 500mM;

[0061] Then, through phase separation, the fibrous sodium alginate hydrogel is obtained.

[0062] After testing, the content of sodium alginate nanofibers in the prepared fibrous sodium alginate hydrogel is 1%;

[0063] The storage modulus of sodium alginate nanofiber translucent hydrogel is 2000Pa, and it has good thixotropy. It is found that it can withstand 5000% strain and the recovery rate of storage modulus after 50 times of shearing Can be maintained at 90%.

Embodiment 2

[0065] The preparation method is as follows:

[0066] In the first step, use deionized water to prepare a sodium alginate nanofiber solution with a concentration of 2.5% by mass;

[0067] In the second step, while stirring, add Na to the above-mentioned nanofiber solution 2 CO 3 , until the Na in the mixed solution 2 CO 3 The concentration of the ingredients reaches 200mM;

[0068] Then, through phase separation, the sodium alginate nanofiber translucent hydrogel is obtained.

[0069] After testing, in the prepared sodium alginate nanofiber translucent hydrogel, the content of sodium alginate nanofiber is 4%;

[0070] The storage modulus of sodium alginate nanofiber translucent hydrogel is 7000Pa, and it has good thixotropy, and it is found that it can withstand 5000% strain and the recovery rate of storage modulus after 50 times of shearing Can be maintained at 92%.

Embodiment 3

[0072] The preparation method is as follows:

[0073] In the first step, use deionized water to prepare a sodium alginate nanofiber solution with a concentration of 3.5% by mass;

[0074] In the second step, while stirring, add Na to the above-mentioned nanofiber solution 2 SO 4 , until the Na in the mixed solution 2 SO 4 The concentration of the ingredients reaches 100mM;

[0075] Then, through phase separation, the sodium alginate nanofiber translucent hydrogel is obtained.

[0076] After testing, in the prepared translucent hydrogel of sodium alginate nanofibers, the content of sodium alginate nanofibers is 6%;

[0077] The storage modulus of sodium alginate nanofiber translucent hydrogel is 18000Pa, and it has good thixotropy, can withstand 5000% strain, and after 50 shears, the recovery rate of storage modulus can be maintained At 93%.

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Abstract

The invention discloses a preparation method for sodium alginate nanometer fiber-based hydrogel. Additional electrolyte and alcohol are utilized to capture water in a sodium alginate nanometer fiber solution system, so that nanometer fibers get close and gather to intertwine and construct hydrogel in a semitransparent state with a three-dimensional network structure. Under the effect of shearing force, the three-dimensional network structure is easily damaged. After the external force is removed, the network structure can spontaneously reconstruct and the shearing-recovering performance is excellent. Carboxyl and hydroxyl on sodium alginate molecular chain are combined with red blood cells and the red blood cells can be covered in a network in the spontaneous reconstruction process of the extruded three-dimensional network structure, so that the hydrogel can be used for hemostasis without other drug component, the hemostasis speed is higher and the effect is better. Meanwhile, the energy storage modulus is high, the thixotropy is excellent and the method is suitable for 3D printing quick forming of biological material product.

Description

technical field [0001] The invention relates to a preparation method of sodium alginate hydrogel, in particular to a preparation method of sodium alginate nanofiber-based hydrogel, and belongs to the technical field of natural polymer materials. Background technique [0002] Sodium alginate is a natural polysaccharide extracted from the cell wall of brown algae, which is composed of α-L-mannuronic acid (M unit) and β-D-guluronic acid (G unit) through 1,4 -Linear natural polymers connected by glycosidic bonds, with molecular weights ranging from thousands to hundreds of thousands. [0003] Because sodium alginate has excellent biocompatibility, gelatinity and natural flame retardancy, it is widely used in food, medicine, textile and other fields. [0004] Hydrogel has a hydrophobic three-dimensional network structure, which can retain a large amount of water or biological fluid components, and has strong permeability to oxygen, nutrients, metabolic waste, drug molecules, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/04A61L24/00A61L24/08
CPCC08J3/075A61L24/001A61L24/0031A61L24/0042A61L24/08A61L2400/04C08J2305/04C08L5/04
Inventor 隋坤艳王丽男谭业强张庆旭夏延致赵从宪盛楠楠乔海燕
Owner QINGDAO UNIV
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