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Polycomplex gel for treating diseases of intestinal/digestive tract

A technology for digestive tract diseases and complexes, applied in the field of polycomplex gels for the treatment of intestinal/digestive tract diseases, to achieve the effect of preventing disease recurrence, good penetration ability, and stable curative effect

Inactive Publication Date: 2017-08-18
格力佐维特有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This results in the preparation being used only under medical supervision and requiring routine analysis of blood and urine

Method used

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  • Polycomplex gel for treating diseases of intestinal/digestive tract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] For the treatment of nonspecific ulcerative colitis, a polyplex gel with the following composition can be applied:

[0074] Metronidazole: 1.0g;

[0075] Thymogen: 0.01g;

[0076] Carbomer: 1.0g;

[0077] Propylene glycol: 10.0g;

[0078] EDTA disodium salt: 0.05g;

[0079] Propyl p-hydroxybenzoate: 0.02g;

[0080] Methylparaben: 0.04g;

[0081] Sodium hydroxide: sufficient to provide the necessary pH;

[0082] Distilled water: balance.

Embodiment 2

[0084] For the treatment of Crohn's disease, a polyplex gel with the following composition can be applied:

[0085] Metronidazole: 0.8g;

[0086] Thymogen: 0.002g;

[0087] Carbomer: 1.0g;

[0088] Propylene glycol: 10g;

[0089] EDTA disodium salt: 0.04g;

[0090] Propyl p-hydroxybenzoate: 0.025g;

[0091] Methylparaben: 0.04g;

[0092] Sodium hydroxide: sufficient to provide the necessary pH;

[0093] Distilled water: balance.

Embodiment 3

[0095] For the treatment of fistulas, polyplex gels with the following composition can be used:

[0096] Metronidazole: 1.2g;

[0097] Thymogen: 0.015g;

[0098] Carbomer: 1.0g;

[0099] Propylene glycol: 10g;

[0100] EDTA disodium salt: 0.05g;

[0101] Propyl p-hydroxybenzoate: 0.02g;

[0102] Methylparaben: 0.04g;

[0103] Sodium hydroxide: sufficient to provide the necessary pH;

[0104] Distilled water: balance.

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Abstract

The invention relates to the chemical and pharmaceutical industry and consists of a rectal gel substance for treating diseases of the intestinal / digestive tract, including nonspecific ulcerative colitis, Crohn's disease, fistulae, etc., and also complications during the course of treatment of said diseases. The invention provides an antimicrobial and antiprotozoal effect and has good penetration capabilities. The technical result achieved by carrying out the claimed invention consists in increasing the effectiveness of treating non-infectious inflammatory diseases of the intestinal / digestive tract, and in shortening the duration of treatment. Said technical result is achieved by means of a polycomplex gel for treating diseases of the intestinal / digestive tract, said gel containing metronidazole and thymogen as active substances, and containing the following auxiliary substances, in the following composition and ratio of components, in grams, with a total mass of gel of 150 grams: metronidazole: 0.1-2g; thymogen: 0.001-0.05g; carbopol: 0.2-1.0g; propylene glycol: 8.0-11.0g; EDTA disodium salt: 0.001-0.08g; propyl parahydroxybenzoate: 0.015-0.04g; methyl parahydroxybenzoate: 0.035-0.08g; sodium hydroxide: an amount sufficient for producing the necessary pH; distilled water: the remainder.

Description

[0001] field of invention [0002] The present invention relates to the chemical and pharmaceutical industries and consists of a rectal gel substance for the treatment of intestinal / digestive tract diseases including non-specific ulcerative colitis, Crohn's disease, fistulas etc. and complications arising during the course of the disease. [0003] The present invention provides antimicrobial and antiprotozoal action and good penetration capabilities. [0004] Background of the invention [0005] Non-infectious intestinal / digestive tract inflammatory diseases such as ulcerative colitis and Crohn's disease have become one of the most serious problems in modern gastroenterology. The incidence of ulcerative colitis and Crohn's disease is increasing every year and occurs mainly in the adult population, making them socially important diseases. [0006] The similarity of these intestinal / digestive tract insults is due to the fact that they are the basis of chronic destruction of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/4164A61K38/05A61K47/58A61P1/00
CPCA61K38/05A61K9/10A61K47/50A61K31/4164A61P1/00A61P1/04A61K9/0007A61K31/4174A61K47/183A61K47/32A61K9/0031A61K9/06A61K47/02A61K47/10A61K47/14
Inventor G·M·霍罗维特斯
Owner 格力佐维特有限责任公司
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