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Process for extracting astilbin from Engelhardia roxburghiana Wall leaves

A technology of astilbin and technology, which is applied in the field of extracting active ingredients from leaves of Huangqi, and can solve the problems of low extraction yield and purity of astilbin

Inactive Publication Date: 2017-08-18
南宁馨艺荣生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The problem of low extraction yield and purity of astilbin extracted from leaves

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A process for extracting astilbin from Huangqi leaves, comprising the following steps:

[0040] S1: Pulverize the leaves of Huang Qi and pass through a 50-mesh sieve to obtain the powder of Huang Qi leaves;

[0041] S2: Add 82% ethanol 7 times its weight to the Huangqi leaf powder prepared in step S1, reflux extraction twice under water bath conditions, each extraction time is 2.3h, combine the extract after the extraction is complete, and adjust the pH of the extract value to 4, the temperature is controlled at 80°C, decolorized and impurity removed by activated carbon for 1 hour, and a decolorized solution is obtained after filtration;

[0042] S3: Concentrate and dry the primary decolorization solution obtained in step S2 to obtain an extract extract, which is dissolved in water at 52°C with 5.6 times the volume of the extract extract, and extracted twice with anhydrous ethyl acetate solvent, and then continue to use Anhydrous ethyl acetate is carried out crystalliz...

Embodiment 2

[0047] A process for extracting astilbin from Huangqi leaves, comprising the following steps:

[0048] S1: Pulverize the leaves of Huang Qi and pass through a 40-mesh sieve to obtain Huang Qi leaves powder;

[0049] S2: Add 6 times the weight of 76% ethanol to the Huangqi leaf powder prepared in step S1, reflux extraction twice under water bath conditions, each extraction time is 1.8h, combine the extract after the extraction is complete, and adjust the pH of the extract When the temperature reaches 3.2, the temperature is controlled at 79°C, decolorized and removed by activated carbon for 1.2h, and filtered to obtain a decolorized solution;

[0050] S3: Concentrate and dry the primary decolorization solution obtained in step S2 to obtain an extract extract, which is dissolved in water at 43° C. with 5 times the volume of the extract extract, extracted twice with anhydrous ethyl acetate solvent, and continued to use Anhydrous ethyl acetate is carried out crystallization treatme...

Embodiment 3

[0055] A process for extracting astilbin from Huangqi leaves, comprising the following steps:

[0056] S1: Pulverize the leaves of Huang Qi and pass through a 60-mesh sieve to obtain Huang Qi leaves powder;

[0057] S2: Add 8 times its weight of 84% ethanol to the Huangqi leaf powder prepared in step S1, reflux extraction under water bath conditions for 3 times, each extraction time is 2.6h, combine the extract after the extraction is complete, and adjust the pH of the extract value to 4.5, the temperature is controlled at 81°C, decolorized and removed by activated carbon for 0.6h, and filtered to obtain a decolorized solution;

[0058] S3: Concentrate and dry the primary decolorization solution obtained in step S2 to obtain an extract extract, which is dissolved in water at 58°C with 6.2 times the volume of the extract extract, extracted 3 times with anhydrous ethyl acetate solvent, and continued to use Anhydrous ethyl acetate was crystallized three times, and the solid-to-l...

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Abstract

The invention discloses a process for extracting astilbin from Engelhardia roxburghiana Wall leaves, and belongs to the technical field of extraction of active ingredients from Engelhardia roxburghiana Wall leaves. The astilbin is prepared by the following steps: pulverizing, first decolorizing, coarse crystallization, second decolorizing, separation and purification by macroreticular resin, concentration and crystallization, drying and the like. The extraction yield of the prepared astilbin is 65.48% or above, the purity is 98.16% or above, and the extraction yield and the purity are higher than the extraction yield and the purity of the astilbin prepared in the prior art.

Description

[0001] 【Technical field】 [0002] The invention belongs to the technical field of extracting active ingredients from leaves of huang qi, and in particular relates to a process for extracting astilbin from leaves of huang qi. [0003] 【Background technique】 [0004] Astilbin (astilbin) 3,3,4',5,7-pentahydroxyflavanone 3-(6-deoxy-(L-mannopyranside)) is a dihydroflavonol compound, which was first obtained from Kozo Hayashi and KazahikoOuchi in 1950 Extracted from the plant Astilbe. [0005] It has been reported in the literature that astilbin has insecticidal, coenzyme A reductase, aldose reductase, analgesic and anti-edema activities. Astilbin can also significantly improve immune liver injury, and inhibit delayed hypersensitivity by inhibiting the function of activated T lymphocytes. [0006] Huang Qiye is the dried leaf of Huang Qi, a plant of the family Juglandaceae, which is distributed in Guangdong, Guangxi, Yunnan and other provinces, and the resources are quite rich. It...

Claims

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Application Information

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IPC IPC(8): C07H17/07C07H1/08
CPCC07H17/07C07H1/08
Inventor 黄健军梁可文黄能梁可武谢冬养
Owner 南宁馨艺荣生物科技有限公司
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