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A kind of preparation method of microneedle system

A microneedle and silicone rubber technology, applied in the field of microneedle systems, can solve the problems of low electrical signal quality, expensive equipment, and increased production costs, and achieve the effects of fast and simple preparation methods, increased applicability, and improved quality

Active Publication Date: 2020-04-24
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the following processes are generally used at home and abroad to prepare invasive dry electrodes based on microneedle arrays: silicon wafer preparation and thermal oxidation of silicon dioxide; use photolithography to make microneedle array patterns; use silicon deep decoration to form needle column arrays; Use chemical corrosion to corrode the needle column to form a sharp electrode head; cover the electrode surface with a metal conductive layer; however, using the above method to make electrodes involves expensive equipment, which increases the production cost, and the process is relatively complicated
At present, some people in China use the method of pouring low-melting point alloys into templates to prepare invasive dry electrodes based on microneedle arrays. However, the substrate of this system is hard and cannot fit the human body, resulting in low quality electrical signals. This method needs to make templates in advance, and the process cycle is long

Method used

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  • A kind of preparation method of microneedle system
  • A kind of preparation method of microneedle system

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preparation example Construction

[0022] The preparation method of the microneedle system provided by the present invention comprises the following steps:

[0023] 1) Making the base: Mix the silicone rubber pre-preparation and its curing agent, stir well and vacuumize for more than 10 minutes to remove air bubbles, then pour the liquid silicone rubber with the curing agent on the petri dish, and place it in an oven for heating Curing for more than 1 hour, and then tearing off the cured solid silicone rubber from the petri dish;

[0024] 2) Making microneedles: Heat the low-melting point liquid alloy to above 60°C to liquid state, pour it into the syringe of the dispensing machine, place the flexible silicone rubber base under the needle of the dispensing machine, set the shape of the dispensing array, z Axis speed (10mm / s-180mm / s), syringe dwell time (0.1s-2s) and sample ejection time (0.1s-2s) before dispensing;

[0025] 3) Making a conductive layer: spraying gallium-indium alloy onto the surface of the mic...

Embodiment 1

[0029] 1) Make the substrate: Mix the polydimethylsiloxane prepolymer and the curing agent at a volume ratio of 10:1, stir well and vacuumize for 10 minutes to remove air bubbles, and then put the liquid polydimethylsiloxane prepolymer with the curing agent The siloxane was poured onto the petri dish, and dried in an oven at 80° C. for 2 hours to obtain a solid polydimethylsiloxane substrate, which was torn off from the petri dish.

[0030] 2) Making microneedles: heat the bismuth-indium-tin-zinc alloy with a melting point of 57.5°C to 80°C to a liquid state, pour it into the syringe of the dispenser, place the flexible silicone rubber base under the needle of the dispenser, and use the program to set The shape of the fixed-point glue array is 6x6, the interval between two microneedles is 0.8 mm, the z-axis speed is 30 mm / s, the residence time of the syringe is 0.2 seconds, and the sample output time is 0.3 seconds, and then the program is run for dispensing.

[0031] 3) Makin...

Embodiment 2

[0034] 1) Make the substrate: Mix the polydimethylsiloxane prepolymer and the curing agent at a volume ratio of 10:1, stir well and vacuumize for 10 minutes, remove the air bubbles, and then add the curing agent to the liquid The polydimethylsiloxane was poured onto the petri dish, and placed in an oven at 80°C for 2 hours to obtain a solid polydimethylsiloxane substrate, which was then torn off from the petri dish.

[0035] 2) Making microneedles: heat the bismuth-indium-tin-zinc alloy with a melting point of 57.5°C to 80°C to a liquid state, pour it into the syringe of the dispenser, place the flexible silicone rubber base under the needle of the dispenser, and use the program to set The shape of the fixed-point glue array is 4x4, the interval between the two microneedles is 2 mm, the z-axis speed is 30 mm / s, the residence time of the syringe is 0.2 seconds, and the sampling time is 0.3 seconds, and then the program is run for dispensing.

[0036] 3) Making the conductive la...

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Abstract

A microneedle system and a preparation method thereof belong to the technical field of medical devices. The invention prepares a flexible microneedle system by using low-melting-point alloy as the raw material of the microneedle, and the liquid alloy at normal temperature as the conductive layer. The method includes: preparing a flexible silicon rubber base, preparing a microneedle, preparing a conductive layer and preparing an encapsulation layer. The microneedles have good mechanical strength and can penetrate the stratum corneum of the skin, while the flexible silicone rubber base can ensure that the system fits the skin better and increases the comfort of the human body. Compared with the traditional method, the preparation method of the present invention is simpler and faster, and avoids material waste. The invention can be used for the detection of physiological electrical signals such as electroencephalogram, electrocardiogram and myoelectricity, and can meet the needs of scientific research and clinical practice.

Description

technical field [0001] The present invention relates to a microneedle system. The invention can simplify the manufacturing process and improve the quality of the collected human body electrical signals. Background technique [0002] Bioelectrical signal is one of the main physiological parameters of the human body, which can be used for clinical diagnosis and postoperative and intraoperative monitoring. Therefore, it is of great significance to improve the quality of the collected physiological electrical signals. Most of the physiological electrical signals are collected through the contact between the electrodes and the human body, and the performance of the electrodes will directly affect the quality of the collected signals. [0003] The outermost layer of the skin, the stratum corneum, has a high impedance. Traditional epidermal electrodes are coated on the stratum corneum with a conductive paste containing a high concentration of conductive ions. The conductive paste...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/04B81B7/00B81C1/00
CPCB81B7/0032B81C1/00261A61B2562/125A61B2562/0209B81C2201/0174A61B5/24A61B5/263
Inventor 刘冉郭盛欣
Owner TSINGHUA UNIV
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