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A kind of high-efficiency hemostatic sponge and preparation method thereof

A hemostatic sponge, a high-efficiency technology, applied in the field of biomedicine, can solve the problems of slow hemostatic speed, unstable hemostatic effect, local inflammatory response, etc., and achieve the effect of enhanced stability, easy process production, and high hemostatic activity

Active Publication Date: 2020-05-29
GUANGDONG OCEAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These hemostatic materials are effective in the application of mild bleeding wounds, but the hemostatic effect on severe bleeding wounds is unstable, such as slow hemostasis, local inflammatory reactions, and the risk of entering the blood circulation system to cause peripheral thrombus, etc., the use of which is controversial.

Method used

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  • A kind of high-efficiency hemostatic sponge and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0027] Dissolve 3.5g of sodium alginate and 1.5g of sodium hyaluronate in 100mL of purified water, prepare sodium alginate solution and sodium hyaluronate solution, mix well, add 0.45g of calcium chloride to the mixture, mix well, let stand After 30 minutes, the inner layer solution was obtained. Put the inner layer solution into the mold and pre-freeze it at -30°C; then, dissolve 3.5g of chitosan (molecular weight: 50kDa, deacetylated degree 95%) and 0.1g polyglutamic acid (molecular weight 1000kDa), prepare chitosan solution and polyglutamic acid solution, add 0.05g thrombin in the chitosan solution, mix, then polyglutamic acid Add the solution to the chitosan mixed solution, mix well, and let stand for 30 minutes to obtain the surface layer solution; pour the surface layer solution into the frozen mold containing the inner layer solution, and pre-freeze overnight at -30°C; finally, freeze-dry, Packing and sterilizing to get the finished product.

Embodiment 2

[0029] Dissolve 3.5g of sodium alginate and 1.0g of sodium hyaluronate in 100mL of purified water, prepare sodium alginate solution and sodium hyaluronate solution, mix well, add 0.5g of calcium chloride to the mixture, mix well, let stand After 30 minutes, the inner layer solution was obtained. Put the inner layer solution into the mold and pre-freeze it at -30°C; then, dissolve 3.8g of chitosan (molecular weight: 20kDa, deacetylated degree 85%) and 0.29g polyglutamic acid (molecular weight 700kDa), prepare chitosan solution and polyglutamic acid solution, add 0.01g thrombin in the chitosan solution, mix, then polyglutamic acid Add the solution to the chitosan mixed solution, mix well, and let stand for 30 minutes to obtain the surface layer solution; pour the surface layer solution into the frozen mold containing the inner layer solution, and pre-freeze overnight at -30°C; finally, freeze-dry, Packing and sterilizing to get the finished product.

Embodiment 3

[0031] Dissolve 2.0g of sodium alginate and 0.86g of sodium hyaluronate in 100mL of purified water, prepare sodium alginate solution and sodium hyaluronate solution, mix well, add 0.1g of calcium chloride to the mixture, mix well, let stand After 30 minutes, the inner layer solution was obtained. Put the inner layer solution into a mold, and pre-freeze it at -30°C; then, dissolve 6.0 g of chitosan (molecular weight: 3 kDa, deacetylated degree 75%) and 0.1g polyglutamic acid (molecular weight 900kDa), prepare chitosan solution and polyglutamic acid solution, add 0.04g thrombin in the chitosan solution, mix, and then polyglutamic acid Add the solution to the chitosan mixed solution, mix well, and let stand for 30 minutes to obtain the surface layer solution; pour the surface layer solution into the frozen mold containing the inner layer solution, and pre-freeze overnight at -30°C; finally, freeze-dry, Packing and sterilizing to get the finished product.

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Abstract

The invention discloses efficient hemostatic sponge. The efficient hemostatic sponge is prepared from the following raw materials in percentage by mass: 35%-60% of chitosan, 0.1%-0.5% of thrombin, 1%-3% of polyglutamic acid, 9% of sodium chloride, 20%-35% of sodium alginate, 5%-15% of sodium hyaluronate and 1%-5% of calcium chloride. The efficient hemostatic sponge comprises a surface layer and an inner layer, wherein the surface layer is an antibacterial hemostatic layer containing chitosan, thrombin, polyglutamic acid and sodium chloride; and the inner layer is a gel layer containing sodium alginate, sodium hyaluronate and calcium chloride. The inner layer of the hemostatic sponge is in direct contact with a wound and is capable of absorbing moisture in blood to form gel to block the wound so as to realize primary hemostasis; concentrated blood penetrates through the gel layer to enter the surface layer so as to realize further hemostasis with the combined action of thrombin and chitosan; immobilized thrombin on an outer layer in the hemostatic sponge is capable of enhancing the stability, preserves efficient hemostatic activity and is unlikely to enter blood to cause a thrombus risk; and the efficient hemostatic sponge is particularly applicable to rapid hemostasis of serious bleeding caused by deep wounds, arteriorrhexis and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and more specifically relates to a high-efficiency hemostatic sponge and a preparation method thereof. Background technique [0002] In the hemostasis in trauma treatment of sudden accidents and clinical operations, especially in the on-site rescue of injured persons in wars, rapid and efficient hemostasis can effectively reduce casualties and alleviate later complications. Traditional hemostatic materials have unsatisfactory hemostatic effects on wounds such as irregular shapes, deep, narrow, and ruptured arteries. Therefore, there is a need for a fast, safe and efficient hemostatic material suitable for on-site and clinical first aid to replace traditional hemostatic materials. [0003] Chitosan is a natural biological polysaccharide produced after deacetylation of chitin. It is the only alkaline polysaccharide in nature so far, and its natural resources are very rich. Due to its excellen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/10A61L24/06A61L24/02A61L24/00
CPCA61L24/0015A61L24/02A61L24/06A61L24/08A61L24/10A61L2300/232A61L2300/254A61L2300/418A61L2400/04C08L5/08C08L5/04C08L89/00C08L77/04
Inventor 胡章李思东洪鹏志程瑜黄娜廖铭能孔松芝
Owner GUANGDONG OCEAN UNIVERSITY
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