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Method for rapidly detecting preparation process of Qizhi Weitong granules with NIRS (near infrared spectroscopy) and application

A technology of near-infrared spectroscopy and near-infrared spectroscopy, which is applied in measuring devices, material analysis by optical means, instruments, etc. question

Inactive Publication Date: 2017-08-11
辽宁华润本溪三药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the low efficiency of traditional analysis methods, not only greatly affects the production efficiency, but also it is difficult to reflect the complex chemical and physical changes in the extraction process and concentration process

Method used

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  • Method for rapidly detecting preparation process of Qizhi Weitong granules with NIRS (near infrared spectroscopy) and application
  • Method for rapidly detecting preparation process of Qizhi Weitong granules with NIRS (near infrared spectroscopy) and application
  • Method for rapidly detecting preparation process of Qizhi Weitong granules with NIRS (near infrared spectroscopy) and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0143] Example 1 Study on the Water Extraction Process of Qizhi Weitong Granules by Near Infrared Spectroscopy

[0144] 1. Instruments and reagents

[0145] 1.1 Main medicinal materials and reagents

[0146] Bupleurum, Radix Paeoniae Alba, Radix Glycyrrhizae, Corydalis Corydalis (burning) (provided by Liaoning China Resources Benxi Sanyao Co., Ltd.); reference substance of paeoniflorin (Chengdu Master Biotechnology Co., Ltd., batch number: MUST-11030608); acetonitrile (Merck, Germany ); Phosphoric Acid (Aladdin); Wahaha Purified Water.

[0147] 1.2 Main instruments and equipment

[0148] Agilent1200 high-performance liquid chromatography (Agilent1200 pump, Agilent1200 photoelectric secondary array detector, Agilent1200 chromatographic workstation, Agilent Technologies, USA); Antaris Fourier transform near-infrared spectrometer (Thermo Nicolet, USA); equipped with a corresponding transmission detector accessory sampling system and signal acquisition and data processing sof...

Embodiment 2

[0186] Example 2 Study on the extraction of volatile oil in the preparation process of Qizhi Weitong Granules by near-infrared spectroscopy

[0187] 1. Instruments and reagents

[0188] 1.1 Main medicinal materials and reagents

[0189] Citrus aurantium and Rhizoma Cyperi (burnt), provided by Liaoning China Resources Benxi Sanyao Co., Ltd.; neohesperidin reference substance (Chengdu Master Biological Technology Co., Ltd., batch number: MUST-11030701); naringin reference substance (Chengdu Mansi Special Biotechnology Co., Ltd., batch number: MUST-11030612); acetonitrile (Merck, Germany); phosphoric acid (Aladdin); Wahaha purified water.

[0190] 1.2 Main instruments and equipment

[0191] With the 1.2 content under embodiment 1 item.

[0192] 2. Methods and results

[0193] 2.1 Collection of extract samples

[0194] Put 12kg of medicinal materials containing Fructus Aurantii Fructus and Rhizoma Cyperi into a multifunctional extraction tank with a volume of 40L, and extra...

Embodiment 3

[0232] Example 3 Study on the concentration process of the extract in the preparation of Qizhi Weitong Granules by near-infrared spectroscopy

[0233] 1. Experimental materials

[0234] 1.1 Medicinal materials and reagents

[0235] Qi stagnation Weitong granule concentrate (provided by Liaoning China Resources Benxi Sanyao Co., Ltd.); paeoniflorin reference substance (Chengdu Master Biotechnology Co., Ltd., batch number: MUST-11030608); acetonitrile (Merck, Germany); phosphoric acid (Aladdin); Wahaha pure water.

[0236] 1.2 Main instruments and equipment

[0237] With the 1.2 content under embodiment 1 item.

[0238] 2. Methods and results

[0239] 2.1 Collection of concentrate samples

[0240] Since the concentration equipment (coil-type vacuum concentration pot) in the production workshop of Liaoning China Resources Benxi Sanyao can take out samples of the concentrated liquid during the concentration process, the samples during the concentration process were collecte...

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Abstract

The invention relates to a method for rapidly detecting a preparation process of Qizhi Weitong granules with NIRS (near infrared spectroscopy) and an application. An NIRS online analysis method for a water extraction process, a volatile oil extraction process and an extracting solution concentration process of the preparation process of the Qizhi Weitong granules is established and applied to online detection, so that automatic detection of the preparation process of the Qizhi Weitong granules and real-time prediction of content of each quality control index are realized; an established model is high in prediction precision and accuracy and meets the requirement for quantitative analysis in actual production; compared with a traditional pharmacopeia method, the method has the advantages that on the premise that the accuracy is guaranteed, the analysis efficiency is increased greatly, the quality of the extraction processes can be monitored and controlled in real time rapidly and efficiently, and accordingly, guarantee of safety, stability and effectiveness of the quality of final products is facilitated.

Description

technical field [0001] The invention belongs to the field of drug detection, and in particular relates to a method and application for rapidly detecting the preparation process of Qi stagnation Weitong granules by using near-infrared spectroscopy. Background technique [0002] Qi stagnation stomach pain granules are made of 6 traditional Chinese medicines of Bupleurum, Corydalis Corydalis, Fructus Citrifolia, Cyperi Cyperi, Radix Paeoniae Alba and Radix Glycyrrhiza. The treatment of epigastric pain and other diseases has become the first-line drug for clinical treatment of epigastric pain after years of clinical practice. However, the preparation process of Qizhi Weitong Granules is complex and cumbersome, and slight changes in various process parameters in the actual production process may directly affect the quality of the final drug. [0003] Traditional drug analysis techniques generally use off-line analysis methods to collect liquid medicine from extraction tanks and ...

Claims

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Application Information

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IPC IPC(8): G01N21/3577G01N21/359G01N30/02
CPCG01N21/3577G01N21/359G01N30/02
Inventor 孟宪生何晓霞潘英韩凌包永睿王帅李天娇樊佳新
Owner 辽宁华润本溪三药有限公司
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