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Spidroin tissue repair material

A spider silk protein and tissue repair technology, which is applied in the field of biomaterials and spider silk protein, can solve problems such as difficult to achieve blood vessel formation and tissue repair functions, achieve good tissue repair functions, increase specific surface area, and promote blood vessel formation Effect

Inactive Publication Date: 2017-08-11
WUHU YANGZHAN NEW MATERIAL TECH SERVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the existing technologies are pure silk fibroin materials, and it is difficult to achieve the ideal function of promoting angiogenesis and tissue repair.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A spider silk protein tissue repair material, which is a membrane containing spider silk protein, with an internal average pore density of 1-2000 / mm 2 , the average pore size is 1-300 μm, and it is characterized in that, the film-like substance contains the following raw materials by weight: 80 parts of spider silk protein solution, 4 parts of spider silk protein nanofiber solution, acetaminophen sustained-release microcapsules 4 parts, 1 part essential oil.

[0022] Described paracetamol sustained-release microcapsules is to dissolve 2 mass parts of paracetamol in 70 mass parts of water, and add 1 mass part of hydrophilic emulsifier, and emulsify under the action of a magnetic stirrer. The reaction is prepared, the stirring rate of the magnetic stirrer is 1000-3000rpm, and the emulsification time is 30-40min.

[0023] The spider silk protein nanofiber solution is prepared by the following method: the spider silk protein solution is placed in a 60°C incubator and conce...

Embodiment 2

[0031] A spider silk protein tissue repair material, which is a membrane containing spider silk protein, with an internal average pore density of 1-2000 / mm 2 , the average pore size is 1-300 μm, and it is characterized in that, the film-like material contains the following raw materials by weight: 90 parts of spider silk protein solution, 6 parts of spider silk protein nanofiber solution, acetaminophen sustained-release microcapsules 5 parts, 2 parts essential oil.

[0032] Described paracetamol sustained-release microcapsules is to dissolve 3 mass parts of paracetamol in 80 mass parts of water, and add 3 mass parts of hydrophilic emulsifiers, and emulsify under the action of a magnetic stirrer. The reaction is prepared, the stirring rate of the magnetic stirrer is 1000-3000rpm, and the emulsification time is 30-40min.

[0033] The spider silk protein nanofiber solution is prepared by the following method: the spider silk protein solution is placed in a 60°C incubator and con...

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Abstract

The invention provides a spidroin tissue repair material. The spidroin tissue repair material is membranoid substance containing spidroin, the inside average hole density is 1-2000 / mm<2>, and the average hole size is 1-300 [mu] m. The spidroin tissue repair material is characterized in that the membranoid substance contains the following raw materials in parts by weight: 80-90 parts of spidroin solution, 4-6 parts of spidroin nanofiber solution, 4-5 parts of paracetamol slow-release microcapsules, and 1-2 parts of essential oil. The invention relates to the fields of biological materials and spidroin. A biological material for repairing the damaged large tissue and complicated organs needs to have the capacity of promoting the formation of the blood vessels for enabling the large tissue and the complicated organs to have the biological function. But in the prior art, mostly, only the pure fibroin repair materials are available, the ideal blood vessel formation promoting effect and tissue repairing function are difficult to realize, while the tissue repair material prepared by adopting the scheme provided by the invention has the good tissue repairing effect.

Description

technical field [0001] The invention relates to the field of biological materials and spider silk proteins, in particular to a spider silk protein tissue repair material. Background technique [0002] Tissue engineering technology is a new method for treating tissue and organ defects, which is composed of biological scaffolds, cells, growth factors and other elements. Among them, bioscaffolds play an important role in tissue engineering as physical supports for cell growth, proliferation and new tissue formation. Tissue engineering aims to restore and reconstruct the structural and functional integrity of damaged tissues or organs, while the repair of complex tissues and organs cannot be addressed today. Unlike simple thin-layered tissues, large tissues and complex organs can obtain nutrients and oxygen through the diffusion of small molecules. They need to pass through a huge vascular system to obtain nutrients and oxygen. Biomaterials for repairing damaged large tissues ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/36A61L27/54A61L27/56
CPCA61L27/227A61L27/3637A61L27/54A61L27/56A61L2300/21A61L2300/30A61L2300/41A61L2300/412A61L2300/602A61L2300/622A61L2400/12A61L2430/34
Inventor 吴长应
Owner WUHU YANGZHAN NEW MATERIAL TECH SERVICE CO LTD
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