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Method, device and system for hydrodynamic flow focusing

A fluid power, focusing device technology, applied in measurement devices, fluid controllers, laboratory containers, etc., can solve problems such as large hardware costs and increased complexity of fluid interconnect electronics

Inactive Publication Date: 2017-08-01
FOSS ANALYTICAL AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Four or five flow pumps result in considerable hardware expense and add complexity with many fluidic interconnects and more electronics
In addition, the system is only used for fluorescence that is not used for imaging

Method used

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  • Method, device and system for hydrodynamic flow focusing
  • Method, device and system for hydrodynamic flow focusing
  • Method, device and system for hydrodynamic flow focusing

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Embodiment Construction

[0125] the term

[0126] The term "microparticle" refers to small particles, but not limited to micron-sized, <500 microns, and not limited to biological cells. The particles are preferably dielectric, but may also be optically metallic.

[0127] The term "substrate" as used herein refers to a sheet of material of constant thickness, which is preferably transparent and of optical quality, but is not limited thereto. Preferred are glass, quartz, SU-8, polycarbonate, cycloolefin copolymer (COC) polymers such as Polystyrene, Polymethylmethacrylate (PMMA). The substrate need not be a hard rigid sheet, but could also be a soft foil, such as polydimethylsiloxane (PDMS) or other elastomeric material. The thickness of the substrate is typically 0.25 mm to 1 mm thick, but is not limited to this thickness range.

[0128] The term "substrate plane" refers to a geometric plane parallel to the top or bottom of the substrate.

[0129] The term "substrate normal" refers to the directio...

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Abstract

In a method for hydrodynamic focusing of a laminar and planar sample fluid flow, a system is provided for analysis and / or sorting of microscopic objects in the sample fluid comprising an optical objective for optical inspection of the microscopic objects. Microscopic objects are conveyed in the laminar flow of the sample fluid, and two laminar and planar flow of sheath fluids are provided. The flow of the sample fluid is hydrodynamically focused at an optical inspection zone of the system by the sheath fluids. Focusing of the flow of the sample fluid is controlled such that all of the microscopic objects in the sample fluid are caused to be conveyed in a common flow direction in one single plane at the inspection zone of the system, and the microscopic objects in the fluid are optically inspected through the optical objective.

Description

technical field [0001] The present invention relates to the field of flow cytometry. In particular, the invention relates to the field of hydrodynamic flow focusing and the construction of flow cells (called hydrodynamic flow focusing devices) and their use in optical analysis or optical laser sorting of biological cells and particles (called microscopic objects). The flow cell can be implemented as a microfluidic flow cell. Background technique [0002] introduce [0003] In biotechnology, clinical diagnostics and research, there is a need to study and sort biological cells on an individual basis, which can be done with instruments capable of flow cytometry and cell sorting. Flow cytometry is a tool in the cytometry, analysis of cells and bacteria. It is a statistical tool that uses a large number of events, individual cell measurements, to derive information about cell function, affinities, populations, etc. Therefore, high throughput (speed) is necessary to measure a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00G01N15/14
CPCB01L3/502776G01N15/1404G01N15/147G01N15/1484B01L2400/0454B01L2200/0636B01L2200/0652G01N2015/1006G01N2015/1413G01N2015/1415G01N15/01G01N15/149B01L3/502746B01L3/502761B01L2300/0654B01L2300/0864B01L2400/082
Inventor L·H·瑞多夫J·格鲁克斯塔德T·艾艾波
Owner FOSS ANALYTICAL AS
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