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Oral care compositions containing biodegradable particles with superior aesthetics

A technology for oral care and biodegradation, applied in the fields of promoting oral health and preparing oral care compositions, which can solve undesirable problems

Active Publication Date: 2017-08-01
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such degradation profiles appear to be undesirable for aqueous products where degradation during storage and use is undesirable

Method used

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  • Oral care compositions containing biodegradable particles with superior aesthetics
  • Oral care compositions containing biodegradable particles with superior aesthetics
  • Oral care compositions containing biodegradable particles with superior aesthetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] Example 1 - Structured Mouthwash

[0096] Three mouthwash formulations A, B and C were prepared by mixing the ingredients described in Table 1 below. Formulations A and B as shown in Table 1 with a combination of xanthan gum (0.110% by weight, Formulation A and 0.090% by weight, Formulation B) and gellan gum (0.147% by weight, Formulation A and 0.122% by weight, Formulation B) Be structured. Formulation C contains no gum component. NaCl was used to achieve viscosities in the range of 255 to 595 (reported in centipoise (cps) in Table 1, where 1 cps = 0.001 Pa·s). 0.5% by weight of FD&C Blue No. 1 aluminum lake (approximately 230 μm in diameter) encapsulated in polylactic acid was added to each formulation. Encapsulated particles were obtained from MicroPowders, lnc., Tarrytown, NY.

[0097] The viscosity of the mouthwash formulations was measured at 25°C at 1 rpm using a Brookfield Viscometer Model HADV-II+Pro (available from Brookfield Engineering Laboratories, Mi...

Embodiment 2

[0112] Example 2. Aqueous gel toothpaste

[0113] An aqueous gel toothpaste having a mouthwash breath freshening component and a toothpaste cleansing component was prepared by mixing the ingredients described in Table 2. 0.3 wt% PLA spots were added to the formulation. Viscosity and YS values ​​are determined as described above.

[0114] As indicated in Table 2, the final viscosity of the formulations ranged from 120,000 to 270,000 cps. The pH is in the range of 7.0 to 9.0.

[0115] PLA flecks have similar specific gravity values ​​to the continuous phase of toothpaste. A uniform distribution of PLA spots was maintained during the storage period of three months. Without being limited by theory, evenly distributed spots are provided by low concentrations of silica thickener and xanthan gum, which contribute to the static yield stress of the formulation ( YS). PLA spots remained intact in this formulation after three months of aging under accelerated conditions.

[0116...

Embodiment 3

[0119] Example 3. Aqueous toothpastes and gels

[0120] will have white (TiO 2 ), blue (FD&C Blue Lake 1, combination of green (FD&C Blue Aluminum Lake, D&C Yellow 5 Lake), and red (FD&C 40 / lake) PLA spots formulated in aqueous toothpaste or gel formulations to assess robustness and / or the compatibility of these formulations with different ingredients. Formulations E-H as shown in Table 3 were prepared by mixing the indicated ingredients. Viscosity and YS were determined as above except that due to the higher viscosity of the formulations the Smaller (V74) guide vane blades to ensure the maximum torque capacity of the instrument is not exceeded.

[0121] As noted in Table 3, the final viscosity of the formulations ranged from 226,000 to 554,000 cps and the pH ranged from 7.33 to 8.05. As also indicated in the table, three month aging evaluations under controlled room temperature and accelerated high temperature conditions resulted in acceptable chemically and physically st...

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Abstract

Disclosed is a stable oral care composition including an orally acceptable vehicle, and a colorant encapsulated by a biodegradable polymer. Methods of preparing the stable oral care composition and using the oral care composition to promote oral health are also disclosed.

Description

Background technique [0001] Dyes encapsulated in polyethylene have been added to toothpastes, mouthwashes and other oral care compositions to provide colored spots or other colorful decorative patterns in order to improve consumer acceptance of these products. While polyethylene has been used to encapsulate dyes used in aesthetic products, there is growing public concern that microplastics can contribute to global pollution because they are not readily biodegradable. [0002] Biodegradable polymers such as polylactic acid are known in the art. Polylactic acid and its degradation products, namely H 2 O and CO 2 It is neither toxic nor carcinogenic to the human body. Therefore, such polymers are useful in biomedical applications. [0003] For example, polylactic acid polymers have been reported as useful carriers for drugs such as small molecules and proteins. The degradation properties of these polymers via hydrolysis are beneficial for drug release into the patient. Howe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/84A61K8/11A61Q11/00
CPCA61K8/11A61K8/84A61K2800/41A61K2800/42A61Q11/00A61K8/85A61K2800/43A61K8/042A61K8/22A61K8/466A61K2800/48
Inventor 罗伯特·丹布罗焦
Owner COLGATE PALMOLIVE CO
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