Preparation method of p-methylsulfonyl benzaldehyde
A technology of p-thymphenyl and thiamphenyltoluene, which is applied in the field of preparation of p-thymphenyl benzaldehyde, can solve the problems of affecting economic benefits, complicated operation, poor yield, etc., and achieves high economic benefits, simple synthesis process, low cost effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
preparation example Construction
[0016] The invention provides a preparation method of p-thiamphenicol benzaldehyde, which comprises dissolving p-thiamphenicol toluene and a catalyst in water respectively, mixing and reacting to obtain the p-thiamphenicol benzaldehyde, the catalyst being 1,4 - Dichloro-1,4-diazacyclo[2,2,2]octane.
[0017] As can be seen from the foregoing description, the beneficial effects of the present invention are:
[0018] (1) Using p-thiamphenyltoluene as the starting material, water as the solvent, and 1,4-dichloro-1,4-diazacyclo[2,2,2]octane as the catalyst, it can be prepared p-thymphenylbenzaldehyde has the advantages of easy-to-obtain raw materials, low cost, high final product yield and high purity;
[0019] (2) The preparation method is simple, easy to operate, suitable for large-scale industrial production, and has high economic benefits;
[0020] (3) Less impurities are introduced, which is convenient for subsequent purification operations.
[0021] Further, the reaction t...
Embodiment 1
[0037] The preparation method of the p-thiamphenicyl benzaldehyde of the present embodiment comprises: dissolving p-thiamphenicol toluene in a solvent, adding 1,4-dichloro-1,4-diazacyclo[2,2,2] Under the action of alkane, the reaction solution was extracted, dried, filtered, and distilled under reduced pressure to obtain p-thiamphenicol benzaldehyde.
[0038] Among them, 1,4-dichloro-1,4-diazacyclo[2,2,2]octane is prepared by dissolving triethylenediamine in an organic solvent and passing chlorine gas.
[0039] The preparation route of p-thiamphenicyl benzaldehyde comprises:
[0040] 1. Preparation of catalyst 1,4-dichloro-1,4-diazacyclo[2,2,2]octane:
[0041] Take an appropriate amount of 1,4-diazacyclo[2,2,2]octane and add it into chloroform, and pass through chlorine gas to react at 25°C for 10 minutes, and remove the solvent under reduced pressure to obtain almost pure 1,4-dioxane Chloro-1,4-diazacyclo[2,2,2]octane, the yield reached 98%.
[0042] 2. Preparation of p-th...
Embodiment 2
[0045] The preparation method of the p-thiamphenicyl benzaldehyde of the present embodiment comprises: dissolving p-thiamphenicol toluene in a solvent, adding 1,4-dichloro-1,4-diazacyclo[2,2,2] Under the action of alkane, the reaction solution was extracted, dried, filtered, and distilled under reduced pressure to obtain p-thiamphenicol benzaldehyde.
[0046] Among them, 1,4-dichloro-1,4-diazacyclo[2,2,2]octane is prepared by dissolving triethylenediamine in an organic solvent and passing chlorine gas.
[0047] The preparation route of p-thiamphenicyl benzaldehyde comprises:
[0048] 1. Preparation of catalyst 1,4-dichloro-1,4-diazacyclo[2,2,2]octane:
[0049]Take an appropriate amount of 1,4-diazacyclo[2,2,2]octane and add it into chloroform, and pass through chlorine gas to react at 20°C for 5 minutes, and remove the solvent under reduced pressure to obtain almost pure 1,4- Dichloro-1,4-diazacyclo[2,2,2]octane with a yield of 98%.
[0050] 2. Preparation of p-thiamphenicy...
PUM
Login to view more Abstract
Description
Claims
Application Information
Login to view more - R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap