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Medical operation glue liquid

A technology of glue and surgery, which is applied in the field of medical devices, can solve the problems of hemostasis and poor anti-adhesion ability, and achieve good biological safety, prevent infection, and prevent adhesion.

Inactive Publication Date: 2017-07-11
WUHAN YIJIABAO BIOMATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has very excellent technical effects in terms of washing effect, antibacterial effect, adverse reactions, biocompatibility, moisturizing performance, hemostatic performance, repairing effect, etc., which solves the problems existing in the use of existing washing products, but also Poor hemostasis and anti-adhesion ability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The sodium carboxymethyl cellulose used in this example is sodium carboxymethyl cellulose with a degree of substitution of 0.7 and 0.9 mixed according to 1:1; the calcium alginate used is calcium alginate with a purity of 97% and a powder particle size of 500 nm powder;

[0017] The medical polylactic acid modified ether type waterborne polyurethane material is based on IPDI (isophorone diisocyanate), 2000PPG (linear polyether with a molecular weight of 2000), PLLA (polylactic acid) and DMBA (dimethylolbutyric acid) according to A medical-grade polymer solution with a solid content of 40% is obtained by reacting at 80°C for 4 hours with a molar ratio of 4:2:1:1 and then ammoniated with triethylamine and dissolved in water for injection. PH value is around 8

[0018] Put water for injection and sodium carboxymethyl cellulose into a power mixer, heat and stir under vacuum for 1 hour, the heating temperature is 80°C, and the vacuum degree is kept below -0.08MPa, then cool...

Embodiment 2

[0023] The sodium carboxymethylcellulose used in this embodiment is sodium methylcellulose with a degree of substitution of 1.5; the calcium alginate used is a calcium alginate powder with a purity of 97% and a powder particle size of 800nm;

[0024] The medical polylactic acid modified ether type waterborne polyurethane material is based on IPDI (isophorone diisocyanate), 2000PPG (linear polyether with a molecular weight of 2000), PLLA (polylactic acid) and DMBA (dimethylolbutyric acid) according to A medical-grade polymer solution with a solid content of 50% is obtained by reacting at 80°C for 6 hours with a molar ratio of 4:2:1:0.3 and then ammoniated with triethylamine and dissolved in water for injection. PH value is around 7

[0025] Put water for injection and sodium carboxymethyl cellulose into a power mixer, heat and stir under vacuum for 1 hour, the heating temperature is 80°C, and the vacuum degree is kept below -0.08MPa, then cool down and naturally cool to room te...

Embodiment 3

[0030] The sodium carboxymethyl cellulose used in this example is sodium methyl cellulose with a degree of substitution of 1.5 and 0.7 mixed according to 1:6; the calcium alginate used is calcium alginate powder with a purity of 97% and a particle size of 200 nm ;

[0031] The medical polylactic acid modified ether type waterborne polyurethane material is based on IPDI (isophorone diisocyanate), 2000PPG (linear polyether with a molecular weight of 2000), PLLA (polylactic acid) and DMBA (dimethylolbutyric acid) according to A medical-grade polymer solution with a solid content of 45% is obtained by reacting at 80°C for 5 hours with a molar ratio of 4:2:1:0.6, and then ammoniated with triethylamine and dissolved in water for injection. PH value is about 7.8

[0032] Put water for injection and sodium carboxymethyl cellulose into a power mixer, heat and stir under vacuum for 2 hours, the heating temperature is 60°C, and the vacuum degree is kept below -0.08MPa, then cool down an...

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Abstract

The invention relates to a novel medical operation glue liquid and a preparation method thereof, and the novel medical operation glue liquid comprises the following components by weight: 100 parts of medical grade injection water, 1-10 parts of sodium carboxymethyl cellulose, 0.3-20 parts of calcium alginate and 2-40 parts of a medical polylactic acid modified polyether type waterborne polyurethane material. The novel medical operation glue liquid is packed by a sterile medical infusion bottle, is simple and easy to use, can be saved in the environment at room temperature for 24 months without losing efficacy, and has good flushing and hemostatic effects on surgical entocoele and acute wounds, the novel medical operation glue liquid is a human body-absorbable material without side effects and bio-risks, and after flushing, the novel medical operation glue liquid can form a tough protective film on the surface of the wounds, and has good anti infection, adhesion-preventing and wound healing accelerating effects.

Description

technical field [0001] The invention belongs to the technical field of medical devices and relates to a medical surgical glue, in particular to a single-component addition type medical surgical glue specially used for surgical flushing and trauma. Background technique [0002] In surgical operations, blood loss, blurred vision, and postoperative adhesions have always been the basic issues of whether the operation can be completed quickly and with high quality, and the smaller the blood loss, the lower the risk of surgery. A clear field of vision can greatly reduce the difficulty of surgery, thereby improving surgical performance. The success rate of the operation reduces the possibility of medical accidents. At the same time, "adhesion" is a common complication in abdominal surgery. The possibility of surgery, the difficulty of diagnosis and treatment, and the increase of medical costs. However, at present, domestic doctors have not paid enough attention to the occurrence o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14A61L31/16A61L26/00
Inventor 黄異许世生唐小雄
Owner WUHAN YIJIABAO BIOMATERIAL CO LTD
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