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Application of tripterine in preparation of medicines for treating cholestatic liver disease

A technology for triptolide and cholestasis, which is applied in the directions of drug combinations, pharmaceutical formulations, plant raw materials, etc., to achieve the effects of reducing bile acid components, reducing liver damage, and inhibiting inflammation

Active Publication Date: 2017-07-07
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the application of tripterine for the treatment of cholestatic liver disease has not been reported so far

Method used

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  • Application of tripterine in preparation of medicines for treating cholestatic liver disease
  • Application of tripterine in preparation of medicines for treating cholestatic liver disease
  • Application of tripterine in preparation of medicines for treating cholestatic liver disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Therapeutic effect of tripterine on ANIT-induced cholestatic liver disease in mice:

[0027] Animals: C57BL / 6 mice, SPF grade, 37-40 days old, weighing 20-23 g, male; the certificate numbers are all: SCXK (Xiang) 2013-0004, purchased from Hunan Slack Jingda Experimental Animal Co., Ltd.

[0028] Drugs and reagents: tripterygium, red amorphous crystalline powder, Chengdu Ruifensi Biotechnology Co., Ltd., batch number L‐003‐150420. Aspartate Aminotransferase (AST) Kit (Cat. No. C010‐3, Lot No. 20161031), Alanine Aminotransferase (ALT) Kit (Cat. No. C009‐3, Lot No. 20161031), and Alkaline Phosphatase (ALP ) kits (article number A059-3, batch number 20161031), all produced by Nanjing Jiancheng Institute of Bioengineering. α-Naphthylphenylisothiocyanate (ANIT, product number N4525-10G, batch number 101734146), DMSO (product number V900090-500ml, batch number 101669350), Tween 80 (product number P1754-500ml, batch number 101761909) were purchased from Sigma. Corn oil (produ...

Embodiment 2

[0043] Therapeutic effect of tripterine on TAA-induced cholestatic liver disease in mice:

[0044] Animals: C57BL / 6 mice, SPF grade, 37-40 days old, weighing 20-23 g, male; the certificate numbers are all: SCXK (Xiang) 2013-0004, purchased from Hunan Slack Jingda Experimental Animal Co., Ltd.

[0045] Drugs and reagents: tripterygium, red amorphous crystalline powder, Chengdu Ruifensi Biotechnology Co., Ltd., batch number L‐003‐150420. Aspartate Aminotransferase (AST) Kit (Cat. No. C010‐3, Lot No. 20161031), Alanine Aminotransferase (ALT) Kit (Cat. No. C009‐3, Lot No. 20161031), and Alkaline Phosphatase (ALP ) kits (article number A059-3, batch number 20161031), all produced by Nanjing Jiancheng Institute of Bioengineering. Thioacetamide (TAA, Catalog No. C1290‐25G, Lot No. 1002213299), DMSO (Prod. No. V900090‐500ml, Lot No. 101669350), Tween 80 (Prod. 101721592), Chlorpropamide (Product No. C1290‐25G, Lot No. 1002213299), Cholic Acid (CA, Catalog No. C1129‐25G), Ursodeoxych...

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PUM

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Abstract

The invention discloses application of tripterine in preparation of medicines for treating cholestatic liver disease. The tripterine achieves obvious effects of improving cholestasis and alleviating liver damage on intrahepatic cholestasis induced by mouse alpha-naphthylisothiocyanate (ANIT) and cholestatic liver disease induced by thioacetamide (TAA), can obviously lower levels of aspartic transaminase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in plasma of two models, reduce the cholic acid content in the plasma and promote bile excretion and has the effects of protecting liver and increasing choleresis; and when being applied to research and development of medicines with effects of protecting liver and increasing choleresis, the tripterine can create excellent economic benefits and wide social benefits.

Description

[0001] Technical field: [0002] The invention belongs to the technical field of cholestasis drugs, in particular, relates to the application of tripterine as a drug for treating cholestatic liver diseases. [0003] Background technique: [0004] The most fundamental cause of cholestasis is the accumulation of toxic bile acids in liver cells, which is a disorder in the liver. Cholestasis can lead to liver fibrosis, cirrhosis, liver failure, and even death. Cholestasis is divided into two types: extrahepatic cholestasis and intrahepatic cholestasis: extrahepatic cholestasis is caused by bile duct tumors, cysts, bile duct stones and other diseases; intrahepatic cholestasis is caused by sepsis, drugs, primary biliary cirrhosis, primary It is caused by multiple sclerosing cholangitis, viral hepatitis, alcoholic liver disease, and pregnancy; in addition, there are many genetically induced progressive familial intrahepatic cholestasis (PFIC). - So far, ursodeoxycholic acid (UDCA) a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P1/16
CPCA61K31/56A61P1/16A61K36/37
Inventor 李飞赵琦左之利
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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