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Medicine composition for treating congestive heart failure and application thereof

A technology of heart failure and composition, which is applied in the field of pharmaceutical composition for the treatment of congestive heart failure, can solve the problems of side effects of western medicine, no obvious improvement of clinical symptoms, long-term curative effect needs further verification, etc., and achieves less toxic and side effects and good clinical Application prospects and the effect of reducing the mortality rate of heart failure

Inactive Publication Date: 2017-06-20
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the therapeutic drugs for congestive heart failure are mainly diuretics, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, aldosterone antagonists and β-receptor blockers, etc., but many western medicines have obvious side effects , and the improvement of clinical symptoms in some cases of congestive heart failure is not obvious, and the long-term efficacy needs to be further verified

Method used

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  • Medicine composition for treating congestive heart failure and application thereof
  • Medicine composition for treating congestive heart failure and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] The preparation of embodiment 1 Chinese medicine extract

[0013] Weigh 1.2kg of mouse ear, 1.8kg of black soybean, 0.6kg of tortoise flower, 3.0kg of Niu Dali, 0.6kg of spinach seed, 1.5kg of daylily root, 1.2kg of silver bud, 1.5kg of dry lotus leaf and 1.8kg of Chaotian jar, Combine and pulverize; then add water to the above-mentioned granular medicinal materials to cover the surface of the medicine, soak for 0.5-1h, then remove and place in the extraction device, add water and decoct 3 times, add 135L of water for the first time, boil with high heat and simmer for 2 hours, and decoct for the second time Add 120L of water for the first time, boil with strong fire and simmer for 1.5h, add 120L of water for the third time, boil with strong fire and simmer for 1.5h, combine the decoction, filter, and concentrate the filtrate under reduced pressure at 0.08MPa to a relative density of 1.10 (65°C test), add 95% ethanol to make the volume alcohol content reach about 75%, st...

Embodiment 2

[0014] Embodiment 2 Chinese medicine extract is to the influence test of isoproterenol congestive heart failure rat model

[0015] 40 clean-grade male SD rats, 8 weeks old, after one week of adaptive feeding, 8 were randomly selected as blank controls, and other rats were subcutaneously injected with isoproterenol (ISO, 170mg / kg, divided into 2 times, with an interval of 24h). ) for modeling, and blank control rats were subcutaneously injected with 0.25 ml of normal saline. After 6 weeks of modeling, color ultrasound monitor was used to measure relevant indicators in two-dimensional imaging mode in the left ventricular short-axis view at the papillary muscle level, and the measured values ​​were the average of 5 cardiac cycles. Modeling was successful when the left ventricular ejection fraction (LVEF) was less than or equal to 45%. 24 successful model rats were randomly divided into model control group, high-dose and low-dose Chinese medicine groups, 8 rats in each group. Af...

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Abstract

The invention discloses a medicine composition for treating congestive heart failure and application thereof. The medicine composition is prepared from supernate obtained through treating the following traditional Chinese medicinal materials by a water extraction and alcohol sedimentation method: 9 to 15 parts of lineate supplejack leaves, 15 to 22 parts of black beans, 4 to 8 parts of bitter citrus immature flowers, 27 to 33 parts of millettia specisoa champ roots, 4 to 8 parts of spinach fruits, 12 to 18 parts of radices hemerocallis, 9 to 15 parts of barbate cyclea roots or stems, 12 to 18 parts of dry lotus leaves and 15 to 22 parts of wideleaf osbeckia roots. When the medicine composition is used as the medicine for treating the congestive heart failure, the medicine effect is comprehensive; the illness state of patients with congestive heart failure can be fast relieved; the heart failure death rate is reduced.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for treating congestive heart failure and its application. Background technique [0002] Congestive heart failure is commonly seen in the terminal stage of various organic heart diseases, and refers to myocardial systolic or / and diastolic dysfunction, which leads to decreased cardiac output, insufficient perfusion of surrounding tissues, and failure to meet the needs of tissue metabolism. sign. The clinical morbidity and mortality are increasing year by year, seriously affecting the quality of life of patients and even endangering their lives. At present, the main therapeutic drugs for congestive heart failure are diuretics, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, aldosterone antagonists and β-receptor blockers, etc., but many western medicines have obvious side effects , and th...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61P9/04
CPCA61K36/896A61K36/185A61K36/28A61K36/48A61K36/486A61K36/59A61K36/72A61K36/752A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 董俊霞
Owner QINGDAO MUNICIPAL HOSPITAL
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