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Amikacin sulfate injection and preparation method thereof

A technology of amikacin sulfate and injection, which is applied in the field of medicine, can solve the problems of painful urinary streak, blood in the urine, difficulty in urination, etc., and achieves the effects of alleviating pain, increasing the probability of cure, and enriching treatment methods.

Inactive Publication Date: 2017-06-13
JIANGSU HFQ BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When a dog has a urinary system infection, symptoms such as frequent urination, difficulty urinating, blood in the urine, and painful urination may occur; if not treated in time, the bacteria will continue to ascend, causing cystitis, nephritis and other diseases in dogs Dogs cause more serious harm

Method used

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  • Amikacin sulfate injection and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Amikacin sulfate injection, per 100ml injection, consists of the following raw materials: 5g of amikacin sulfate, 0.01g of sodium bisulfite, 0.05g of EDTA-2Na, 20ml of wild chrysanthemum distillate, 5ml of forsythia distillate .

[0026] Its preparation method comprises the following steps:

[0027] (1) Weigh Amikacin Sulfate, Sodium Bisulfite, EDTA-2Na in proportion, and then add them into appropriate amount of purified water, stir evenly, then add 0.2% (w / v) activated carbon, stir and keep warm for 50-60 °C to obtain solution A;

[0028] (2) stirring the prepared forsythia distillate into solution A to obtain solution B;

[0029] (3) Add the prepared wild chrysanthemum distillate to solution B, then add dilute alkali solution to adjust the pH value to 5.0, and finally add purified water to constant volume;

[0030] (4) Filter and decarbonize the solution in step (3), steam sterilize at 110° C. for 40 minutes to obtain Amikacin Sulfate Injection.

[0031] With the ...

Embodiment 2

[0033] Amikacin sulfate injection, per 100ml injection, is composed of the following raw materials: Amikacin sulfate 1g, sodium bisulfite 0.1g, EDTA-2Na 0.5g, wild chrysanthemum distillate 25ml, forsythia distillate 5ml .

[0034] Its preparation method comprises the following steps:

[0035] (1) Weigh Amikacin Sulfate, Sodium Bisulfite, EDTA-2Na in proportion, and then add them into appropriate amount of purified water, stir evenly, then add 0.2% (w / v) activated carbon, stir and keep warm for 50-60 °C to obtain solution A;

[0036] (2) stirring the prepared forsythia distillate into solution A to obtain solution B;

[0037] (3) Add the prepared wild chrysanthemum distillate to solution B, then add dilute alkali solution to adjust the pH value to 4.0, and finally add purified water to constant volume;

[0038] (4) Filter and decarburize the solution in step (3), and steam sterilize at 120°C for 30 minutes to obtain Amikacin Sulfate Injection.

Embodiment 3

[0040] Amikacin sulfate injection, per 100ml injection, consists of the following raw materials: Amikacin sulfate 15g, sodium bisulfite 0.1g, EDTA-2Na 0.01g, wild chrysanthemum distillate 10ml, forsythia distillate 15ml .

[0041] Its preparation method comprises the following steps:

[0042] (1) Weigh Amikacin Sulfate, Sodium Bisulfite, EDTA-2Na in proportion, then add them into appropriate amount of purified water in turn, stir evenly, then add 0.2% (w / v) activated carbon, stir and keep warm for 50-60 °C to obtain solution A;

[0043] (2) stirring the prepared forsythia distillate into solution A to obtain solution B;

[0044] (3) Add the prepared wild chrysanthemum distillate to solution B, then add dilute alkali solution to adjust the pH value to 5.5, and finally add purified water to constant volume;

[0045] (4) Filter and decarburize the solution in step (3), steam sterilize at 125° C. for 30 minutes to obtain Amikacin Sulfate Injection.

[0046] 1. Stability test: ...

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Abstract

The invention discloses an amikacin sulfate injection and a preparation method thereof. Each 100ml of amikacin sulfate injection is prepared from the following raw materials: 0.5-40g of amikacin sulfate, 0.01-0.5g of sodium hydrogen sulfite, 0.01-0.5g of EDTA-2Na, 10-25ml of wild chrysanthemum flower distillate and 5-15ml of fructus forsythia distillate. The amikacin sulfate injection is combined with existing Chinese herbal medicines fructus forsythia and wild chrysanthemum flower according to the pharmacological effects of the amikacin, so that the drug resistance of gram negative bacteria is relieved; the amikacin sulfate injection is an effective supplement of the drug for treating animal urinary tract infection at present; meanwhile, the treatment means on the disease are enriched; and the amikacin sulfate injection is used for treating urinary system and respiratory tract infection and digestive tract infection caused by multiple pathogenic bacteria, increasing the healing probability and relieving the pain of infected animals.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical preparation, in particular to an amikacin sulfate injection and a preparation method thereof. Background technique [0002] Amikacin Sulfate is a semi-synthetic aminoglycoside antibiotic whose antibacterial spectrum is similar to that of gentamicin. Its characteristic is that it is still effective against gentamicin and kanamycin-resistant Pseudomonas aeruginosa, Escherichia coli, Proteus, and Klebsiella; it also has a good effect on Staphylococcus aureus. It is mainly used to treat bacteremia, sepsis, respiratory tract infection, peritonitis and various infections caused by sensitive bacteria caused by drug-resistant bacteria. It is mainly excreted through the kidneys, and the concentration in the urine is very high. The plasma concentration is about 0.5 ~ 1h to reach the peak value, and the half-life in dogs is 0.98 ~ 1.07h. [0003] Dog urinary system infe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61K9/08A61P31/04A61P11/00A61P13/00A61P1/00A61K31/7036
CPCA61K9/0019A61K9/08A61K31/7036A61K36/287A61K36/634A61K47/183A61K2300/00
Inventor 卢静琼
Owner JIANGSU HFQ BIO TECH CO LTD
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