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Dual-chamber bag for peritoneal dialysis

A peritoneal dialysis and dialysate technology, which is applied in peritoneal dialysis, dialysis systems, packaging items, etc., can solve the problems of inconvenient transportation and placement of peritoneal dialysis bags, product scrapping, and the impact of glucose degradation speed, etc., to achieve easy opening and protection Welding, easy to fold effect

Inactive Publication Date: 2017-06-13
HUAREN PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides a double-chamber bag for peritoneal dialysis, which solves the problems in the prior art that the peritoneal dialysis bag is inconvenient to transport and place, the product is likely to be scrapped, and the fast glucose degradation speed affects the curative effect of peritoneal dialysis

Method used

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  • Dual-chamber bag for peritoneal dialysis
  • Dual-chamber bag for peritoneal dialysis
  • Dual-chamber bag for peritoneal dialysis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] In the dialysate after mixing the first medicinal liquid in the first medicinal liquid chamber and the second medicinal liquid in the second medicinal liquid chamber, the glucose concentration is 1.5w / v%, the calcium ion concentration is 1.75mmol / L, and the magnesium ion concentration is 1.75mmol / L. 0.25mmol / L, lactate ion 40mmol / L, according to the ratio and concentration shown in Table 1, the preparation of liquid medicine, under each experimental condition prepared 3 batches of samples, filled into the double-chamber bag, experimental Both are prepared with water for injection; wherein, the first liquid medicine chamber contains glucose (C 6 h 12 o 6 •H 2 O), calcium chloride (CaCl 2 • 2H 2 O), magnesium chloride (MgCl 2 •6H 2 O), the second liquid chamber contains sodium chloride (NaCl), sodium lactate (C 3 h 5 NaO 3 ).

[0029] After the above peritoneal dialysate was sterilized at high temperature (121°C, 15min), the contents of two main glucose degradat...

Embodiment 2

[0036] According to the design ratio of Example 1 (ratio A-ratio D), the double-chamber bag is designed, and the double-chamber bag adopts the same heat sealing strength (6-9N) to pass the first liquid medicine chamber and the second liquid medicine chamber through the virtual welding rod Connection; investigate the safety, reliability and anti-vibration ability (weld part) of double-chamber bags with different design ratios under different distances and different time conditions, and study whether they meet the stability of virtual welding during transportation and placement; There are five boxes of double-chamber bags (water-filled) in each design ratio, a total of 20 boxes, each box has four bags, and each journey has undergone four loading and unloading. The experimental results are shown in Table 3.

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Abstract

The invention discloses a dual-chamber bag for peritoneal dialysis, and belongs to the technical field of peritoneal dialysis. The dual-chamber bag for the peritoneal dialysis comprises a bag body, a first medicine liquid chamber and a second medicine liquid chamber which are provisionally partitioned are formed in the bag body, a penetrating agent is arranged in the first medicine liquid chamber, and the volume of the first medicine liquid chamber accounts for 15% to 40% of the total volume of the bag body; a buffering agent is arranged in the second medicine liquid chamber, and the volume of the second medicine liquid chamber accounts for 60% to 85% of the total of the bag body. According to the dual-chamber bag for the peritoneal dialysis, the volume and the ratio of the first medicine liquid chamber and the volume and the ratio of the second medicine liquid chamber are scientifically designed, medicine liquid with the penetrating agent is located in the medicine liquid chamber with the small volume, the pH value is 2.5 to 4.0, small generation of glucose degradation products in the low-pH-value environment is achieved, and the physiological pH after the two medicine liquid chambers are mixed is also achieved; the large medicine liquid chamber and the small medicine liquid chamber are reasonable in design, energizing is easy, pseudo soldering is easy to break, and using is convenient; folding of the bag body is convenient, pseudo soldering is protected, and the product scraping phenomenon generated by pseudo soldering breaking in the transportation process and the placing process of products is avoided.

Description

technical field [0001] The invention belongs to the technical field of peritoneal dialysis, in particular to a double-chamber bag for peritoneal dialysis. Background technique [0002] Peritoneal dialysis (PD) uses the peritoneum as a semipermeable membrane. Water and solutes are exchanged between the peritoneal capillaries and the dialysate. Electrolytes and small molecules move from the side with high concentration to the side with low concentration (diffusion effect). Water molecules move from the side with low osmotic concentration to the side with high osmotic concentration (osmosis), increasing the concentration of dialysate can achieve the purpose of removing water in the body; through the gradient difference of solute concentration, uremic substances in the blood can be removed from the dialysate. Clear, and maintain electrolyte and acid-base balance, instead of part of the function of the kidneys. Due to its special advantages of home treatment, easy operation, red...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J1/10A61M1/28
CPCA61J1/10A61M1/287
Inventor 李继仁沈圣民
Owner HUAREN PHARMACEUTICAL CO LTD
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