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Preparation method of chitosan gel series material

A technology of chitosan and gel, which is applied in the field of preparation of chitosan gel-based materials, can solve the problems of high energy consumption and uneconomical, and achieve low cost, environmental protection and operator health, and excellent product performance Effect

Active Publication Date: 2017-06-06
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the high energy consumption and uneconomical problems in the preparation process of the existing chitosan gel material, and provide a safe, low energy consumption, and green chemical preparation of chitosan gel by chitin material method

Method used

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  • Preparation method of chitosan gel series material
  • Preparation method of chitosan gel series material
  • Preparation method of chitosan gel series material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The commercially available chitin was soaked in 4wt% NaOH aqueous solution for 48h, filtered and washed with 1wt% HCl aqueous solution for 6h, filtered and washed with water, and freeze-dried to obtain chitin powder with a degree of acetylation of 93%. The mixed solvent of 20g potassium hydroxide, 4g urea and 81g water is pre-cooled to -20°C, 1g of chitin is added, and the mixture is pre-cooled to -20°C for 12h. Thaw at room temperature to obtain a transparent chitin solution, put it in a blast oven set at 60 ℃, and heat for 2 hours to gel and deacetylate. Place the deacetylated chitosan gel in a 75% ethanol aqueous solution for 72 hours and wash with water to obtain a physically cross-linked chitosan hydrogel. The measured tensile strength is 0.3MPa, the breaking strain is 110%, and the water content is 92wt. %, the degree of deacetylation is 51%.

Embodiment 2

[0030] The commercially available chitin was soaked in 4wt% NaOH aqueous solution for 48h, filtered and washed with 1wt% HCl aqueous solution for 6h, filtered and washed with water, and freeze-dried to obtain chitin powder with a degree of acetylation of 93%. A mixed solvent of 20g potassium hydroxide, 4g urea, and 81g water is pre-cooled to -20°C, 1g of chitin is added, and the mixture is pre-cooled to -20°C and kept for 12 hours. Thaw at room temperature to obtain a transparent chitin solution, put it in a blast oven set at a temperature of 40 ℃, and heat for 12 hours to gel and deacetylate. The deacetylated chitosan gel was placed in deionized water for 72 hours and washed with water to obtain a physically crosslinked chitosan hydrogel. The measured compressive strength was 1.3MPa, the breaking strain was 83%, and the moisture content was 97wt%. The degree of acetylation is 58%.

Embodiment 3

[0032] The commercially available chitin was soaked in 4wt% NaOH aqueous solution for 48h, filtered and washed with 1wt% HCl aqueous solution for 6h, filtered and washed with water, and freeze-dried to obtain chitin powder with a degree of acetylation of 93%. The mixed solvent of 20g potassium hydroxide, 4g urea and 81g water is pre-cooled to -20°C, 1g of chitin is added, and the mixture is pre-cooled to -20°C for 12h. Thaw at room temperature to obtain a transparent chitin solution, put it in a blast oven set at a temperature of 50 ℃, and heat for 12 hours to gel and deacetylate. The deacetylated chitosan gel was placed in deionized water for 72 hours and washed with water to obtain a physically crosslinked chitosan hydrogel. The measured compressive strength was 1.3MPa, the breaking strain was 79%, and the moisture content was 96wt%. The degree of acetylation is 62%.

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Abstract

The invention discloses a method for preparing a chitosan gel series material directly by using chitin. The material is prepared from hydrogel and aerogel. The method comprises the steps of dissolving the chitin into a solvent of alkali-urea, and heating in a sealing way for realizing homogeneous phase deacetylation of the chitin so as to obtain chitosan alkaline gel; removing alkali liquor urea in the chitosan alkaline gel by using a non-solvent replacement method, and then obtaining physically crosslinked chitosan hydrogel; adding a chemical cross-linking agent into a chitin solution, stirring and then heating to obtain partially crosslinked chitosan alkaline gel; removing alkali liquor urea in the chitosan alkaline gel by using a solvent replacement method, and then obtaining physically and chemically bi-crosslinked chitosan hydrogel; drying to remove the solvent in the chitosan hydrogel and chitosan organic gel so as to obtain chitosan aerogel. The chitosan is derived from the chitin in the natural world and has excellent biocompatibility and biodegradability; therefore, the chitosan gel series material has great application prospect in the field of bio-medical treatment.

Description

Technical field [0001] The invention relates to a method for preparing a chitosan gel-based material, which belongs to the field of new materials. Background technique [0002] In recent years, as the only positively charged natural polysaccharide in nature, chitosan has made significant progress in the application of flexible electronic devices, hemostasis, drug transportation, water treatment, metal extraction and recovery and other fields. Chitosan is a product of deacetylation of chitin. When the degree of deacetylation is above 55%, chitosan can only be dissolved in acidic aqueous solutions. Chitosan gel-based materials include wet hydrogels, gel fibers, gel microspheres, dry aerogels, dry films, silk and so on. Traditional chitosan gel-based materials are based on the chitosan acidic aqueous solution as a starting point, materials prepared by physical and chemical methods, they have a weakness that they have weak mechanical properties. The development of a chitosan gel-ba...

Claims

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Application Information

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IPC IPC(8): C08J3/24C08J3/075C08J3/03C08L5/08
CPCC08J3/03C08J3/075C08J3/24C08J2305/08
Inventor 蔡杰钟奕张俐娜
Owner WUHAN UNIV
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