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Aortic dissection blood flow shear force induces vascular cells to release inflammatory factors and affects the function of pulmonary epithelial cells using a microfluidic chip device

A technology of aortic dissection and microfluidic chip, which is applied in the field of cell biomechanical experimental devices and can solve problems such as unclearness

Active Publication Date: 2019-04-05
FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But how an aortic dissection triggers the inflammatory response and how this inflammatory response can lead to lung injury is still unclear

Method used

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  • Aortic dissection blood flow shear force induces vascular cells to release inflammatory factors and affects the function of pulmonary epithelial cells using a microfluidic chip device
  • Aortic dissection blood flow shear force induces vascular cells to release inflammatory factors and affects the function of pulmonary epithelial cells using a microfluidic chip device
  • Aortic dissection blood flow shear force induces vascular cells to release inflammatory factors and affects the function of pulmonary epithelial cells using a microfluidic chip device

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Embodiment Construction

[0028] As shown in the accompanying drawings, the device of the present invention includes a joint culture chamber of vascular endothelial cells and smooth muscle cells, a circulation system of front and rear load elements, a lung epithelial cell culture chamber and its circulation system. The microfluidic chip device includes a liquid storage tank 1, a peristaltic pump 2, a shock absorber 3, a pneumatic pump control system, a three-layer structure of vascular endothelial cell VECs / smooth muscle cell VSMCs joint culture chamber 4, an elastic chamber A6, and an elastic chamber B7 , resistance valve A8, resistance valve B9, lung epithelial cell PECs culture chamber 5 with single-layer structure, silicone pipe and tee; two culture chambers and their peripheral units form two relatively independent circulatory systems, and the two circulatory systems pass through The common liquid storage tank 1 realizes the information communication between VECs / VSMCs and PECs.

[0029] In this e...

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Abstract

The invention belongs to the technical field of cell biomechanics experiment devices and discloses a micro-fluidic chip device for researching aortic dissection aneurysm blood flow shearing force which induces vascular cells to release inflammatory factors to affect pulmonary epithelial cell functions. The micro-fluidic chip device comprises a liquid storage tank, a shock absorber, a peristaltic pump, a pneumatic pump control system, a vascular endothelial cell VECs / smooth muscle cell VSMCs combined cultivation cavity, an elastic cavity A, an elastic cavity B, a resistance valve A, a resistance valve B, a pulmonary epithelial cell PECs cultivation cavity, a silica gel pipeline and a tee joint, wherein the two cultivation cavities and peripheral units of the cultivation cavities can form two independent circulation systems, and the two circulation systems share the liquid storage tank to achieve information communication between the VECs / VSMCs and PECs. The micro-fluidic chip device disclosed by the invention can be successfully applied to researches on oscillatory shearing force and tensile stress which induce vascular cells to release inflammatory factors to affect pulmonary epithelial cell functions.

Description

technical field [0001] The invention belongs to the technical field of cell biomechanics experiment devices, and in particular relates to a microfluidic chip device for studying the effect of vascular cells releasing inflammatory factors on the function of pulmonary epithelial cells induced by aortic dissection aneurysm shear force. Background technique [0002] Aortic dissection, also known as aortic dissection, is one of the most common and most dangerous cardiovascular diseases. When the degenerative disease of the aortic media or the damage of the aortic intima leads to tearing of the aortic intima, blood enters the aortic wall through the tear, destroys the media and travels along the aorta to separate the intima from the outer layer, which is called aortic dissection. Acute hypoxemia is a common complication in patients with acute aortic dissection. It usually begins to appear on the 2nd to 3rd day of the onset. For patients facing dissection rupture at any time, this ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M3/00C12M1/00
CPCC12M23/16C12M23/34C12M35/04C12M41/46
Inventor 栾永覃开蓉于苗王艳霞
Owner FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
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