Implant active surface with chitosan-AMP compound coating

A technology of active surface and chitosan, applied in the direction of coating, prosthesis, drug delivery, etc., can solve the problems of implant loosening, loss, peripheral bone tissue defect, etc., and achieve the effect of efficient sterilization and broad application prospects.

Inactive Publication Date: 2017-05-31
DALIAN SANSHENG SCI & TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Peri-implantitis can lead to the defect and loss of bone tissue around the implant, if not treated in time, it can lead to loosening and falling off of the implant

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) The dental implant with the titanium dioxide nanotube array layer on the surface is ultrasonically cleaned with deionized water, ethanol and acetone in sequence, dried with nitrogen, placed in a vacuum drying oven, and dried at 60°C for 24 hours , put aside;

[0031] (2) Dissolving chitosan in 0.3% acetic acid solution to prepare a 0.5 mg / ml chitosan solution, the deacetylation degree of the chitosan is 50%, and the Mw is 1000 kDa.

[0032] (3) mixing the solution obtained in step (2) with liquid paraffin, the volume ratio is 0.1, and adding Span 80 with a volume concentration of 0.5%, adding the dispersant magnesium stearate simultaneously, the mixture of Span 80 and magnesium stearate The mass ratio is 2:1, stirring at room temperature for more than 1 hour to form a uniform water-in-oil emulsion;

[0033] (4) Add 1ml of cross-linking agent vanillin of 5mg / ml to the water-in-oil emulsion obtained in step (3), and react for 4 hours under stirring at 40° C. to obtai...

Embodiment 2

[0037] (1) The dental implant with the titanium dioxide nanotube array layer on the surface is ultrasonically cleaned with deionized water, ethanol and acetone in sequence, dried with nitrogen, placed in a vacuum drying oven, and dried at 60°C for 24 hours , put aside;

[0038] (2) dissolving chitosan in 3% acetic acid solution to prepare a 5mg / ml chitosan solution, the deacetylation degree of the chitosan is 98%, and the Mw is 1500kDa.

[0039] (3) mixing the solution obtained in step (2) with liquid paraffin, the volume ratio is 0.4, and adding Span 80 with a volume concentration of 1%, adding the dispersant magnesium stearate simultaneously, the mixture of Span 80 and magnesium stearate The mass ratio is 4:1, and stirred at room temperature for more than 1 hour to form a uniform water-in-oil emulsion;

[0040] (4) Add 10 mg / ml cross-linking agent vanillin 1 ml to the water-in-oil emulsion obtained in step (3), and react for 6 hours under stirring at 60° C. to obtain chitos...

Embodiment 3

[0044] The dental implant that step (1) is processed in embodiment 1 is immersed in the chitosan solution described in above embodiment 1 and 2 for 10~20min, so that the surface of the dental implant is positively charged; Deionized water is fully cleaned;

[0045] Submerge the above-mentioned cleaned dental implant in the above-mentioned AMP complex solution with a concentration of 1 mg / ml for 10-20 minutes, so that the surface of the dental implant is negatively charged; then fully wash it with deionized water;

[0046] The dental implant that is processed is immersed in the chitosan solution described in the above embodiments 1 and 2 for 10 to 20 minutes, so that the surface of the dental implant is positively charged; then fully cleaned with deionized water;

[0047] According to the number of layers to be assembled, the steps of Example 3 are repeated more than two times to obtain dental implants with different layers of coatings.

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Abstract

The invention discloses an implant active surface with a chitosan-AMP compound coating and in particular relates to a tooth implant with different layers of coatings. As the chitosan and AMP compound coating are biological materials with good biological degradability and biological compatibility, the coatings of the implant can form molecular coatings which are orderly arranged on the solid surface of the implant mainly through electrostatic attraction between positive ions and negative ions. Due to presence of a chondroitin sulfate layer-antimicrobial peptide compound layer structure on the surface layer, the implant active surface has durable and high-efficiency sterilizing and anti-infection ability; antimicrobial and antiapoptotic activity of the implant active surface can support adhesion, survival, growth and differentiation of varieties of cells (such as osteoblast and cartilage cells); thus, the implant active surface has a wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of dental implants, in particular to an implant active surface with a chitosan-AMP composite coating. Background technique [0002] With the continuous development of dental implant technology and wide recognition by patients, it is also the fastest-growing specialty in stomatology in recent years. It has continuously made breakthroughs and is providing professional help to more patients with dental diseases. However, another current situation that has to be admitted is that the existing interventional devices are prone to infection after being implanted in the body. The main infection mechanism is that the bacteria entering the body first adhere to the surface of the material, and due to the rich nutrient environment in the body, the bacteria reproduce and form a protective biofilm. The presence of biofilms makes infections from medical devices particularly difficult to treat. [0003] Roos. Jansaker et a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/54A61L27/58
CPCA61L27/34A61L27/54A61L27/58A61L2300/252A61L2300/404A61L2300/608A61L2400/18A61L2430/12C08L5/08C08L89/00
Inventor 李丹郭斌张久文蔡俊江彭鹏李闪
Owner DALIAN SANSHENG SCI & TECH DEV
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